BECN1 — 43 ClinVar variants
All ClinVar germline BECN1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
1 Benign · 3 Likely benign · 39 Uncertain significance
Full BECN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BECN1 p.Arg255His Uncertain significance Single submitter
- BECN1 p.Asn286Asp Uncertain significance Single submitter
- BECN1 p.Gln224Glu Uncertain significance Single submitter
- BECN1 p.Glu170Val Uncertain significance Single submitter
- BECN1 p.Glu197Asp Uncertain significance Single submitter
- BECN1 p.Glu210Asp Uncertain significance Single submitter
- BECN1 p.Glu210Gln Uncertain significance Single submitter
- BECN1 p.Gly65Glu Uncertain significance Single submitter
- BECN1 p.Ile125Thr Uncertain significance Single submitter
- BECN1 p.Ile207Thr Uncertain significance Single submitter
- BECN1 p.Ile285Val Uncertain significance Single submitter
- BECN1 p.Ile39Leu Uncertain significance Single submitter
- BECN1 p.Ile70Thr Uncertain significance Single submitter
- BECN1 p.Leu166Trp Uncertain significance Single submitter
- BECN1 p.Leu241Val Uncertain significance Single submitter
- BECN1 p.Leu351Phe Uncertain significance Single submitter
- BECN1 p.Met12Thr Uncertain significance Single submitter
- BECN1 p.Met369Val Uncertain significance Single submitter
- BECN1 p.Thr29Arg Uncertain significance Single submitter
- BECN1 p.Thr343Ser Uncertain significance Single submitter
- BECN1 p.Thr426Pro Uncertain significance Single submitter
- BECN1 p.Tyr413Cys Uncertain significance Single submitter
- BECN1 p.Val154Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- BECN1 p.Arg329Gln Uncertain significance Single submitter
- BECN1 p.Arg80Cys Uncertain significance Single submitter
- BECN1 p.Arg80Leu Uncertain significance Single submitter
- BECN1 p.Gln23Leu Uncertain significance Single submitter
- BECN1 p.Gln240His Uncertain significance Single submitter
- BECN1 p.Gly411Arg Uncertain significance Single submitter
- BECN1 p.Leu148Val Uncertain significance Single submitter
- BECN1 p.Lys345Glu Uncertain significance Single submitter
- BECN1 p.Ser90Phe Uncertain significance Single submitter
- BECN1 p.Ser93Asn Uncertain significance Single submitter
- BECN1 p.Val201Met Uncertain significance Single submitter
All BECN1 variants
Benign 1
- c.980+9T>C Multiple submitters
Likely benign 3
- p.Arg395= Single submitter
- p.Pro350= Single submitter
- p.Thr259Met Single submitter
Uncertain significance 39
- c.-2-2A>G Single submitter
- p.Arg255His Single submitter ⚠
- p.Arg329Gln Single submitter ⚠
- p.Arg80Cys Single submitter ⚠
- p.Arg80Leu Single submitter ⚠
- p.Asn286Asp Single submitter ⚠
- p.Gln224Glu Single submitter ⚠
- p.Gln23Leu Single submitter ⚠
- p.Gln240His Single submitter ⚠
- p.Glu170Val Single submitter ⚠
- p.Glu197Asp Single submitter ⚠
- p.Glu210Asp Single submitter ⚠
- p.Glu210Gln Single submitter ⚠
- p.Gly411Arg Single submitter ⚠
- p.Gly65Glu Single submitter ⚠
- p.Ile125Thr Single submitter ⚠
- p.Ile207Thr Single submitter ⚠
- p.Ile285Val Single submitter ⚠
- p.Ile39Leu Single submitter ⚠
- p.Ile70Thr Single submitter ⚠
- p.Leu148Val Single submitter ⚠
- p.Leu166Trp Single submitter ⚠
- p.Leu222Arg Single submitter
- p.Leu241Val Single submitter ⚠
- p.Leu351Phe Single submitter ⚠
- p.Lys345Glu Single submitter ⚠
- p.Met12Thr Single submitter ⚠
- p.Met254Thr Single submitter
- p.Met369Val Single submitter ⚠
- p.Ser354Cys Single submitter
- p.Ser90Phe Single submitter ⚠
- p.Ser93Asn Single submitter ⚠
- p.Thr273Ala Single submitter
- p.Thr29Arg Single submitter ⚠
- p.Thr343Ser Single submitter ⚠
- p.Thr426Pro Single submitter ⚠
- p.Tyr413Cys Single submitter ⚠
- p.Val154Ile Single submitter ⚠
- p.Val201Met Single submitter ⚠