BID — 50 ClinVar variants
All ClinVar germline BID variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
5 Likely benign · 45 Uncertain significance
Full BID gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BID p.Ala190Thr Uncertain significance Single submitter
- BID p.Arg125Lys Uncertain significance Single submitter
- BID p.Arg168His Uncertain significance Single submitter
- BID p.Arg183Cys Uncertain significance Single submitter
- BID p.Arg183His Uncertain significance Single submitter
- BID p.Arg35Gly Uncertain significance Single submitter
- BID p.Arg63His Uncertain significance Single submitter
- BID p.Arg68His Uncertain significance Single submitter
- BID p.Arg88Lys Uncertain significance Single submitter
- BID p.Arg88Ser Uncertain significance Single submitter
- BID p.Asp75Val Uncertain significance Single submitter
- BID p.Gln133His Uncertain significance Single submitter
- BID p.Glu132Lys Uncertain significance Single submitter
- BID p.Gly104Val Uncertain significance Single submitter
- BID p.Gly70Arg Uncertain significance Single submitter
- BID p.Leu105Pro Uncertain significance Single submitter
- BID p.Leu167Pro Uncertain significance Single submitter
- BID p.Met148Ile Uncertain significance Single submitter
- BID p.Met194Thr Uncertain significance Single submitter
- BID p.Pro103Leu Uncertain significance Single submitter
- BID p.Pro164Leu Uncertain significance Single submitter
- BID p.Ser96Asn Uncertain significance Single submitter
- BID p.Thr163Met Uncertain significance Single submitter
- BID p.Val106Gly Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- BID p.Arg118Trp Uncertain significance Single submitter
- BID p.Arg123Gln Uncertain significance Single submitter
- BID p.Arg34Cys Uncertain significance Single submitter
- BID p.Arg63Pro Uncertain significance Single submitter
- BID p.Arg68Cys Uncertain significance Single submitter
- BID p.Arg84Trp Uncertain significance Single submitter
- BID p.Asn181Lys Uncertain significance Single submitter
- BID p.Asp60Asn Uncertain significance Single submitter
- BID p.Leu113Phe Likely benign Single submitter
- BID p.Pro102Leu Uncertain significance Single submitter
- BID p.Ser76Cys Uncertain significance Single submitter
All BID variants
Likely benign 5
- c.-24C>T Single submitter
- p.Arg84Gln Single submitter
- p.His42Arg Single submitter
- p.Leu113Phe Single submitter ⚠
- p.Thr129Ala Single submitter
Uncertain significance 45
- c.-14G>A Single submitter
- c.-15C>T Single submitter
- c.-23G>A Single submitter
- c.-24C>G Single submitter
- c.-33G>A Single submitter
- c.-39G>A Single submitter
- c.-59+698A>G Single submitter
- c.-59+722C>T Single submitter
- c.-59+723G>T Single submitter
- c.-59+728G>A Single submitter
- c.-59+744C>A Single submitter
- p.Ala190Thr Single submitter ⚠
- p.Arg118Trp Single submitter ⚠
- p.Arg123Gln Single submitter ⚠
- p.Arg125Lys Single submitter ⚠
- p.Arg168His Single submitter ⚠
- p.Arg183Cys Single submitter ⚠
- p.Arg183His Single submitter ⚠
- p.Arg34Cys Single submitter ⚠
- p.Arg35Gly Single submitter ⚠
- p.Arg63His Single submitter ⚠
- p.Arg63Pro Single submitter ⚠
- p.Arg68Cys Single submitter ⚠
- p.Arg68His Single submitter ⚠
- p.Arg84Trp Single submitter ⚠
- p.Arg88Lys Single submitter ⚠
- p.Arg88Ser Single submitter ⚠
- p.Asn181Lys Single submitter ⚠
- p.Asp60Asn Single submitter ⚠
- p.Asp75Val Single submitter ⚠
- p.Gln133His Single submitter ⚠
- p.Glu132Lys Single submitter ⚠
- p.Gly104Val Single submitter ⚠
- p.Gly70Arg Single submitter ⚠
- p.Leu105Pro Single submitter ⚠
- p.Leu167Pro Single submitter ⚠
- p.Met148Ile Single submitter ⚠
- p.Met194Thr Single submitter ⚠
- p.Pro102Leu Single submitter ⚠
- p.Pro103Leu Single submitter ⚠
- p.Pro164Leu Single submitter ⚠
- p.Ser76Cys Single submitter ⚠
- p.Ser96Asn Single submitter ⚠
- p.Thr163Met Single submitter ⚠
- p.Val106Gly Single submitter ⚠