Sugi Variant

Sugi Variant/BIRC6

BIRC6 — 625 ClinVar variants

All ClinVar germline BIRC6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 267 flagged for review →

1 Pathogenic · 1 Conflicting · 42 Benign · 2 Benign/Likely benign · 50 Likely benign · 529 Uncertain significance

Full BIRC6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 267

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 259

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 259

Predictors split 8

The independent predictors disagree with each other — read with care.

All BIRC6 variants

Pathogenic 1

Conflicting classifications of pathogenicity 1

Benign 42

Benign/Likely benign 2

Likely benign 50

Uncertain significance 529

Showing the top 300 by review status; the full set is in the sitemap.