BOLL — 36 ClinVar variants
All ClinVar germline BOLL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
36 Uncertain significance
Full BOLL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BOLL p.Ala172Pro Uncertain significance Single submitter
- BOLL p.Ala259Asp Uncertain significance Single submitter
- BOLL p.Ala267Val Uncertain significance Single submitter
- BOLL p.Arg34Cys Uncertain significance Single submitter
- BOLL p.Asp85Gly Uncertain significance Single submitter
- BOLL p.Cys165Gly Uncertain significance Single submitter
- BOLL p.Gln271His Uncertain significance Single submitter
- BOLL p.Glu238Gly Uncertain significance Single submitter
- BOLL p.Glu238Val Uncertain significance Single submitter
- BOLL p.Glu273Lys Uncertain significance Single submitter
- BOLL p.Glu46Lys Uncertain significance Single submitter
- BOLL p.Glu81Gly Uncertain significance Single submitter
- BOLL p.His255Tyr Uncertain significance Single submitter
- BOLL p.Ile105Val Uncertain significance Single submitter
- BOLL p.Ile121Val Uncertain significance Single submitter
- BOLL p.Leu190Val Uncertain significance Single submitter
- BOLL p.Leu96Pro Uncertain significance Single submitter
- BOLL p.Met122Val Uncertain significance Single submitter
- BOLL p.Met237Thr Uncertain significance Single submitter
- BOLL p.Met265Val Uncertain significance Single submitter
- BOLL p.Pro199Ser Uncertain significance Single submitter
- BOLL p.Ser120Thr Uncertain significance Single submitter
- BOLL p.Ser204Pro Uncertain significance Single submitter
- BOLL p.Thr29Ile Uncertain significance Single submitter
- BOLL p.Tyr138Cys Uncertain significance Single submitter
- BOLL p.Val169Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- BOLL p.Ala172Val Uncertain significance Single submitter
- BOLL p.Ala185Asp Uncertain significance Single submitter
- BOLL p.Lys73Arg Uncertain significance Single submitter
- BOLL p.Pro156Leu Uncertain significance Single submitter
- BOLL p.Pro199Thr Uncertain significance Single submitter
- BOLL p.Ser261Asn Uncertain significance Single submitter
- BOLL p.Ser280Arg Uncertain significance Single submitter
- BOLL p.Val16Met Uncertain significance Single submitter
All BOLL variants
Uncertain significance 36
- p.Ala172Pro Single submitter ⚠
- p.Ala172Val Single submitter ⚠
- p.Ala185Asp Single submitter ⚠
- p.Ala259Asp Single submitter ⚠
- p.Ala267Val Single submitter ⚠
- p.Arg34Cys Single submitter ⚠
- p.Asp85Gly Single submitter ⚠
- p.Cys165Gly Single submitter ⚠
- p.Gln271His Single submitter ⚠
- p.Glu238Gly Single submitter ⚠
- p.Glu238Val Single submitter ⚠
- p.Glu273Lys Single submitter ⚠
- p.Glu46Lys Single submitter ⚠
- p.Glu81Gly Single submitter ⚠
- p.Gly6Arg Single submitter
- p.Gly6Glu Single submitter
- p.His255Tyr Single submitter ⚠
- p.Ile105Val Single submitter ⚠
- p.Ile121Val Single submitter ⚠
- p.Leu190Val Single submitter ⚠
- p.Leu96Pro Single submitter ⚠
- p.Lys73Arg Single submitter ⚠
- p.Met122Val Single submitter ⚠
- p.Met237Thr Single submitter ⚠
- p.Met265Val Single submitter ⚠
- p.Pro156Leu Single submitter ⚠
- p.Pro199Ser Single submitter ⚠
- p.Pro199Thr Single submitter ⚠
- p.Ser120Thr Single submitter ⚠
- p.Ser204Pro Single submitter ⚠
- p.Ser261Asn Single submitter ⚠
- p.Ser280Arg Single submitter ⚠
- p.Thr29Ile Single submitter ⚠
- p.Tyr138Cys Single submitter ⚠
- p.Val169Met Single submitter ⚠
- p.Val16Met Single submitter ⚠