BRD10 — 420 ClinVar variants

All ClinVar germline BRD10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 398 flagged for review →

1 Conflicting · 1 Benign · 16 Likely benign · 402 Uncertain significance

Full BRD10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 398

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

BRD10 p.Ser1309Gly Conflicting Single submitter

Predictors lean, ClinVar uncertain 354

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 354

Predictors split 43

The independent predictors disagree with each other — read with care.

All BRD10 variants

Conflicting classifications of pathogenicity 1

p.Ser1309Gly Single submitter ⚠

Benign 1

p.Pro1552= Multiple submitters

Likely benign 16

p.Val1306Leu Multiple submitters
p.Ala1670Thr Single submitter
p.Gly66Arg Single submitter
p.Ile1076Val Single submitter
p.Ile1173Val Single submitter
p.Ile1433del Single submitter
p.Ile1490Val Single submitter
p.Leu1660Val Single submitter
p.Leu1862Val Single submitter
p.Lys1067Arg Single submitter
p.Pro2042Ser Single submitter
p.Pro321= Single submitter
p.Ser881Leu Single submitter
p.Thr1172= Single submitter
p.Thr1849Ala Single submitter
p.Val1385Met Single submitter

Uncertain significance 402

Showing the top 300 by review status; the full set is in the sitemap.

p.Ala1032Pro Single submitter ⚠
p.Ala1150Thr Single submitter ⚠
p.Ala116Val Single submitter ⚠
p.Ala1182Gly Single submitter ⚠
p.Ala1225Gly Single submitter ⚠
p.Ala1256Val Single submitter ⚠
p.Ala1260Thr Single submitter ⚠
p.Ala1265Gly Single submitter ⚠
p.Ala1456Thr Single submitter ⚠
p.Ala1582Thr Single submitter ⚠
p.Ala1582Val Single submitter ⚠
p.Ala1649Ser Single submitter ⚠
p.Ala1658Thr Single submitter ⚠
p.Ala1676Val Single submitter ⚠
p.Ala1834Val Single submitter ⚠
p.Ala1940Ser Single submitter ⚠
p.Ala1990Thr Single submitter ⚠
p.Ala2084Gly Single submitter ⚠
p.Ala237Gly Single submitter ⚠
p.Ala260Ser Single submitter ⚠
p.Ala293Gly Single submitter ⚠
p.Ala33Val Single submitter ⚠
p.Ala34Pro Single submitter ⚠
p.Ala36Val Single submitter ⚠
p.Ala47Val Single submitter ⚠
p.Ala550Val Single submitter ⚠
p.Ala730Gly Single submitter ⚠
p.Ala908Asp Single submitter ⚠
p.Ala908Thr Single submitter ⚠
p.Ala953Thr Single submitter ⚠
p.Arg1183Thr Single submitter ⚠
p.Arg124Gly Single submitter ⚠
p.Arg1690Gly Single submitter ⚠
p.Arg1773His Single submitter ⚠
p.Arg2081Gln Single submitter ⚠
p.Arg229Cys Single submitter ⚠
p.Arg267Gln Single submitter ⚠
p.Arg271Gly Single submitter ⚠
p.Arg354His Single submitter
p.Arg45Met Single submitter ⚠
p.Arg506Trp Single submitter ⚠
p.Arg575Lys Single submitter ⚠
p.Arg611Ser Single submitter ⚠
p.Arg704Cys Single submitter ⚠
p.Arg704His Single submitter ⚠
p.Arg800Gln Single submitter ⚠
p.Arg813Cys Single submitter ⚠
p.Arg813His Single submitter ⚠
p.Arg835His Single submitter ⚠
p.Asn1022Asp Single submitter ⚠
p.Asn1022Ser Single submitter ⚠
p.Asn1146Asp Single submitter ⚠
p.Asn1297Ser Single submitter ⚠
p.Asn1304Asp Single submitter ⚠
p.Asn1429Thr Single submitter ⚠
p.Asn1431Ser Single submitter ⚠
p.Asn1601Asp Single submitter ⚠
p.Asn1697Asp Single submitter ⚠
p.Asn1697Ser Single submitter ⚠
p.Asn1760Lys Single submitter ⚠
p.Asn1858Ser Single submitter ⚠
p.Asn1948Ser Single submitter ⚠
p.Asn2059Ser Single submitter ⚠
p.Asn699Lys Single submitter ⚠
p.Asn816Ser Single submitter ⚠
p.Asn853Tyr Single submitter ⚠
p.Asp1608Gly Single submitter ⚠
p.Asp1937Gly Single submitter ⚠
p.Asp391Gly Single submitter ⚠
p.Asp391His Single submitter ⚠
p.Asp515Val Single submitter ⚠
p.Asp52Asn Single submitter ⚠
p.Asp52Gly Single submitter ⚠
p.Asp583Gly Single submitter ⚠
p.Asp839Gly Single submitter ⚠
p.Asp839Val Single submitter ⚠
p.Asp865Gly Single submitter ⚠
p.Asp869Gly Single submitter ⚠
p.Asp869Tyr Single submitter ⚠
p.Asp992His Single submitter ⚠
p.Cys1700Arg Single submitter ⚠
p.Cys400Ser Single submitter ⚠
p.Cys526Gly Single submitter ⚠
p.Cys548Ser Single submitter ⚠
p.Cys584Gly Single submitter ⚠
p.Cys585Tyr Single submitter ⚠
p.Cys640Trp Single submitter ⚠
p.Cys70Arg Single submitter ⚠
p.Cys70Ser Single submitter ⚠
p.Gln1088His Single submitter ⚠
p.Gln1163Pro Single submitter ⚠
p.Gln1234His Single submitter ⚠
p.Gln1427Lys Single submitter ⚠
p.Gln150Arg Single submitter ⚠
p.Gln1545Pro Single submitter ⚠
p.Gln1728Glu Single submitter ⚠
p.Gln181Leu Single submitter ⚠
p.Gln183His Single submitter ⚠
p.Gln1866Arg Single submitter ⚠
p.Gln191Leu Single submitter ⚠
p.Gln191Lys Single submitter ⚠
p.Gln1954Lys Single submitter ⚠
p.Gln1984Glu Single submitter ⚠
p.Gln254Arg Single submitter ⚠
p.Gln279Pro Single submitter ⚠
p.Gln336Arg Single submitter ⚠
p.Gln379Glu Single submitter ⚠
p.Gln701Glu Single submitter ⚠
p.Gln846Leu Single submitter ⚠
p.Glu11Ala Single submitter ⚠
p.Glu11Lys Single submitter ⚠
p.Glu1607Lys Single submitter ⚠
p.Glu1607Val Single submitter ⚠
p.Glu1641Ala Single submitter ⚠
p.Glu1809Val Single submitter ⚠
p.Glu327Lys Single submitter ⚠
p.Glu420Lys Single submitter ⚠
p.Glu883Gln Single submitter ⚠
p.Glu976Asp Single submitter ⚠
p.Glu986Gln Single submitter ⚠
p.Gly106Ala Single submitter ⚠
p.Gly106Glu Single submitter ⚠
p.Gly107Ser Single submitter ⚠
p.Gly1131Asp Single submitter ⚠
p.Gly1158Ala Single submitter ⚠
p.Gly1158Glu Single submitter ⚠
p.Gly118Glu Single submitter ⚠
p.Gly123Ser Single submitter ⚠
p.Gly1244Arg Single submitter ⚠
p.Gly136Asp Single submitter ⚠
p.Gly1487Val Single submitter ⚠
p.Gly153Asp Single submitter ⚠
p.Gly1576Glu Single submitter ⚠
p.Gly1622Cys Single submitter ⚠
p.Gly1657Arg Single submitter ⚠
p.Gly173Arg Single submitter ⚠
p.Gly1792Trp Single submitter ⚠
p.Gly1920Glu Single submitter ⚠
p.Gly221Arg Single submitter ⚠
p.Gly25Arg Single submitter ⚠
p.Gly385Ala Single submitter ⚠
p.Gly398Glu Single submitter ⚠
p.Gly596Arg Single submitter
p.Gly620Ala Single submitter ⚠
p.Gly620Ser Single submitter ⚠
p.Gly68Cys Single submitter ⚠
p.Gly862Asp Single submitter ⚠
p.His1055Arg Single submitter ⚠
p.His1391Pro Single submitter ⚠
p.His1536Arg Single submitter ⚠
p.His199Arg Single submitter ⚠
p.His2038Arg Single submitter ⚠
p.His2038Asp Single submitter ⚠
p.His353Tyr Single submitter ⚠
p.His359Arg Single submitter ⚠
p.His43Gln Single submitter ⚠
p.His708Arg Single submitter ⚠
p.His808Arg Single submitter ⚠
p.His892Gln Single submitter ⚠
p.His892Tyr Single submitter ⚠
p.Ile1085Val Single submitter ⚠
p.Ile1179Lys Single submitter ⚠
p.Ile1274Leu Single submitter
p.Ile1433Thr Single submitter ⚠
p.Ile1445Val Single submitter ⚠
p.Ile1481Leu Single submitter ⚠
p.Ile1559Met Single submitter ⚠
p.Ile1575Thr Single submitter ⚠
p.Ile1579Val Single submitter ⚠
p.Ile1593Val Single submitter ⚠
p.Ile1777Val Single submitter ⚠
p.Ile1850Val Single submitter ⚠
p.Ile1878Met Single submitter ⚠
p.Ile1898Val Single submitter ⚠
p.Ile1913Val Single submitter ⚠
p.Ile1943Met Single submitter ⚠
p.Ile1976Val Single submitter ⚠
p.Ile559Leu Single submitter ⚠
p.Ile747Val Single submitter ⚠
p.Ile780Phe Single submitter ⚠
p.Leu1062Ser Single submitter ⚠
p.Leu1062Val Single submitter ⚠
p.Leu1127Phe Single submitter ⚠
p.Leu1371Val Single submitter ⚠
p.Leu1616Ser Single submitter ⚠
p.Leu165Met Single submitter ⚠
p.Leu1660Phe Single submitter ⚠
p.Leu1723Pro Single submitter ⚠
p.Leu1904Pro Single submitter ⚠
p.Leu1912Phe Single submitter ⚠
p.Leu1951Val Single submitter ⚠
p.Leu2013Val Single submitter ⚠
p.Leu2019Phe Single submitter ⚠
p.Leu2039Trp Single submitter ⚠
p.Leu2068His Single submitter ⚠
p.Leu2072Phe Single submitter ⚠
p.Leu341Ile Single submitter
p.Leu364Phe Single submitter ⚠
p.Leu665Ile Single submitter ⚠
p.Leu700Phe Single submitter ⚠
p.Leu707Val Single submitter ⚠
p.Leu815Phe Single submitter ⚠
p.Leu885Val Single submitter ⚠
p.Leu888Val Single submitter ⚠
p.Leu930Arg Single submitter ⚠
p.Leu947Pro Single submitter ⚠
p.Leu97Phe Single submitter ⚠
p.Lys1049Glu Single submitter ⚠
p.Lys1084Asn Single submitter ⚠
p.Lys1115Arg Single submitter ⚠
p.Lys1270Glu Single submitter ⚠
p.Lys1537Gln Single submitter ⚠
p.Lys1609Glu Single submitter ⚠
p.Lys1609Thr Single submitter ⚠
p.Lys1757Thr Single submitter ⚠
p.Lys2064Glu Single submitter ⚠
p.Lys261Arg Single submitter ⚠
p.Lys485Arg Single submitter ⚠
p.Lys511Glu Single submitter
p.Lys551Glu Single submitter ⚠
p.Lys626Asn Single submitter ⚠
p.Lys658Asn Single submitter ⚠
p.Lys716Arg Single submitter ⚠
p.Lys727Gln Single submitter ⚠
p.Lys728Arg Single submitter ⚠
p.Lys731Gln Single submitter ⚠
p.Lys752Asn Single submitter ⚠
p.Lys752Ile Single submitter ⚠
p.Lys805Glu Single submitter ⚠
p.Lys915Thr Single submitter ⚠
p.Lys920Glu Single submitter ⚠
p.Lys924Thr Single submitter ⚠
p.Lys928Glu Single submitter ⚠
p.Lys93Arg Single submitter ⚠
p.Lys952Gln Single submitter ⚠
p.Met1090Ile Single submitter ⚠
p.Met1100Thr Single submitter ⚠
p.Met137Ile Single submitter ⚠
p.Met137Val Single submitter ⚠
p.Met1474Arg Single submitter ⚠
p.Met1474Ile Single submitter ⚠
p.Met1474Leu Single submitter ⚠
p.Met1492Thr Single submitter ⚠
p.Met248Val Single submitter ⚠
p.Met60Val Single submitter ⚠
p.Met898Thr Single submitter ⚠
p.Met907Val Single submitter ⚠
p.Phe1220Leu Single submitter ⚠
p.Phe1333Leu Single submitter ⚠
p.Phe1425Ile Single submitter ⚠
p.Phe1966Cys Single submitter ⚠
p.Phe1970Ser Single submitter ⚠
p.Phe2087Cys Single submitter ⚠
p.Phe905Ile Single submitter ⚠
p.Pro100His Single submitter ⚠
p.Pro1025Leu Single submitter ⚠
p.Pro1043Leu Single submitter ⚠
p.Pro1043Ser Single submitter ⚠
p.Pro1047Arg Single submitter ⚠
p.Pro1047Leu Single submitter ⚠
p.Pro1165Ser Single submitter ⚠
p.Pro1175Thr Single submitter ⚠
p.Pro1227Leu Single submitter ⚠
p.Pro1235Ser Single submitter ⚠
p.Pro1248Ala Single submitter ⚠
p.Pro1298Ala Single submitter ⚠
p.Pro1347Arg Single submitter ⚠
p.Pro1450Leu Single submitter ⚠
p.Pro1469Ala Single submitter ⚠
p.Pro1469Leu Single submitter ⚠
p.Pro1534Ala Single submitter ⚠
p.Pro1546Thr Single submitter ⚠
p.Pro1604Ser Single submitter ⚠
p.Pro1679Leu Single submitter ⚠
p.Pro1679Ser Single submitter ⚠
p.Pro1733Ala Single submitter ⚠
p.Pro1756Leu Single submitter ⚠
p.Pro1763Ser Single submitter ⚠
p.Pro1870Ser Single submitter ⚠
p.Pro1901Leu Single submitter ⚠
p.Pro1955Ala Single submitter ⚠
p.Pro1963Leu Single submitter ⚠
p.Pro1977Ser Single submitter ⚠
p.Pro2028Leu Single submitter ⚠
p.Pro2061Ser Single submitter ⚠
p.Pro2070Ala Single submitter ⚠
p.Pro2083Arg Single submitter ⚠
p.Pro2088Arg Single submitter ⚠
p.Pro2088Ser Single submitter ⚠
p.Pro21Ala Single submitter ⚠
p.Pro21Gln Single submitter ⚠
p.Pro233Leu Single submitter ⚠
p.Pro417Arg Single submitter ⚠
p.Pro498Ser Single submitter ⚠
p.Pro592Leu Single submitter ⚠
p.Pro629Thr Single submitter ⚠
p.Pro631Leu Single submitter ⚠
p.Pro652Ser Single submitter ⚠
p.Pro717Ser Single submitter ⚠
p.Pro7Ser Single submitter ⚠