BRD2 — 136 ClinVar variants
All ClinVar germline BRD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 96 flagged for review →
20 Benign · 2 Benign/Likely benign · 18 Likely benign · 96 Uncertain significance
Full BRD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 96
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRD2 p.Pro12Leu Uncertain significance Multiple submitters
- BRD2 p.Ala295Pro Uncertain significance Single submitter
- BRD2 p.Ala295Ser Uncertain significance Single submitter
- BRD2 p.Ala310Thr Uncertain significance Single submitter
- BRD2 p.Ala626Pro Uncertain significance Single submitter
- BRD2 p.Ala766Val Uncertain significance Single submitter
- BRD2 p.Arg312Pro Uncertain significance Single submitter
- BRD2 p.Arg734Gln Uncertain significance Single submitter
- BRD2 p.Arg739Gly Uncertain significance Single submitter
- BRD2 p.Asn133Ser Uncertain significance Single submitter
- BRD2 p.Asn9Asp Uncertain significance Single submitter
- BRD2 p.Asp794Gly Uncertain significance Single submitter
- BRD2 p.Gln214Pro Uncertain significance Single submitter
- BRD2 p.Gln271Lys Uncertain significance Single submitter
- BRD2 p.Gln337His Uncertain significance Single submitter
- BRD2 p.Gln55Pro Uncertain significance Single submitter
- BRD2 p.Glu14Ala Uncertain significance Single submitter
- BRD2 p.Glu500Asp Uncertain significance Single submitter
- BRD2 p.Glu762Gly Uncertain significance Single submitter
- BRD2 p.Gly18Ala Uncertain significance Single submitter
- BRD2 p.His83Gln Uncertain significance Single submitter
- BRD2 p.Ile162Thr Uncertain significance Single submitter
- BRD2 p.Ile356Thr Uncertain significance Single submitter
- BRD2 p.Ile542Val Uncertain significance Single submitter
- BRD2 p.Leu313Pro Uncertain significance Single submitter
- BRD2 p.Leu82Pro Uncertain significance Single submitter
- BRD2 p.Met121Val Uncertain significance Single submitter
- BRD2 p.Met316Ile Uncertain significance Single submitter
- BRD2 p.Met394Lys Uncertain significance Single submitter
- BRD2 p.Met48Thr Uncertain significance Single submitter
- BRD2 p.Met48Val Uncertain significance Single submitter
- BRD2 p.Phe149Leu Uncertain significance Single submitter
- BRD2 p.Pro12Ser Uncertain significance Single submitter
- BRD2 p.Pro158Ala Uncertain significance Single submitter
- BRD2 p.Pro249Ser Uncertain significance Single submitter
- BRD2 p.Pro259Ser Uncertain significance Single submitter
- BRD2 p.Pro269Ala Uncertain significance Single submitter
- BRD2 p.Pro269Ser Uncertain significance Single submitter
- BRD2 p.Pro471Arg Uncertain significance Single submitter
- BRD2 p.Pro576Leu Uncertain significance Single submitter
- BRD2 p.Pro579Ser Uncertain significance Single submitter
- BRD2 p.Pro58Ser Uncertain significance Single submitter
- BRD2 p.Pro641Leu Uncertain significance Single submitter
- BRD2 p.Pro674Thr Uncertain significance Single submitter
- BRD2 p.Pro753Thr Uncertain significance Single submitter
- BRD2 p.Pro7Ser Uncertain significance Single submitter
- BRD2 p.Thr57Asn Uncertain significance Single submitter
- BRD2 p.Thr750Ala Uncertain significance Single submitter
- BRD2 p.Tyr153Cys Uncertain significance Single submitter
Predictors split 47
The independent predictors disagree with each other — read with care.
- BRD2 p.Ala263Val Uncertain significance Single submitter
- BRD2 p.Ala378Val Uncertain significance Single submitter
- BRD2 p.Arg312Trp Uncertain significance Single submitter
- BRD2 p.Arg406Cys Uncertain significance Single submitter
- BRD2 p.Arg409Gln Uncertain significance Single submitter
- BRD2 p.Arg566Gln Uncertain significance Single submitter
- BRD2 p.Arg701Cys Uncertain significance Single submitter
- BRD2 p.Arg708His Uncertain significance Single submitter
- BRD2 p.Arg773Cys Uncertain significance Single submitter
- BRD2 p.Asn77Ser Uncertain significance Single submitter
- BRD2 p.Asp410Glu Uncertain significance Single submitter
- BRD2 p.Asp570Asn Uncertain significance Single submitter
- BRD2 p.Asp570His Uncertain significance Single submitter
- BRD2 p.Asp799Glu Uncertain significance Single submitter
- BRD2 p.Gln175Glu Uncertain significance Single submitter
- BRD2 p.Gln412Arg Uncertain significance Single submitter
- BRD2 p.Glu459Gln Uncertain significance Single submitter
- BRD2 p.Glu505Gly Uncertain significance Single submitter
- BRD2 p.Glu522Lys Uncertain significance Single submitter
- BRD2 p.Glu532Asp Uncertain significance Single submitter
- BRD2 p.Glu646Asp Uncertain significance Single submitter
- BRD2 p.Gly801Asp Uncertain significance Single submitter
- BRD2 p.His213Tyr Uncertain significance Single submitter
- BRD2 p.His392Leu Uncertain significance Single submitter
- BRD2 p.Leu238Phe Benign Single submitter
- BRD2 p.Leu250Phe Uncertain significance Single submitter
- BRD2 p.Leu262Phe Uncertain significance Single submitter
- BRD2 p.Leu273His Uncertain significance Single submitter
- BRD2 p.Leu704Phe Uncertain significance Single submitter
- BRD2 p.Leu774Phe Uncertain significance Single submitter
- BRD2 p.Lys329Glu Uncertain significance Single submitter
- BRD2 p.Lys555Arg Uncertain significance Single submitter
- BRD2 p.Pro260Leu Uncertain significance Single submitter
- BRD2 p.Pro323Ser Uncertain significance Single submitter
- BRD2 p.Pro431Ala Uncertain significance Single submitter
- BRD2 p.Pro58Arg Uncertain significance Single submitter
- BRD2 p.Pro711Leu Uncertain significance Single submitter
- BRD2 p.Ser486Asn Uncertain significance Single submitter
- BRD2 p.Ser490Phe Uncertain significance Single submitter
- BRD2 p.Ser510Pro Uncertain significance Single submitter
- BRD2 p.Ser591Asn Uncertain significance Single submitter
- BRD2 p.Ser597Ile Uncertain significance Single submitter
- BRD2 p.Ser785Cys Uncertain significance Single submitter
- BRD2 p.Ser786Cys Uncertain significance Single submitter
- BRD2 p.Ser796Thr Uncertain significance Single submitter
- BRD2 p.Thr467Ile Uncertain significance Single submitter
- BRD2 p.Val85Ile Uncertain significance Single submitter
All BRD2 variants
Benign 20
- c.1330-4G>C Single submitter
- c.1579-8del Single submitter
- c.611-4C>G Single submitter
- p.Ala569Thr Single submitter
- p.Ala59= Single submitter
- p.Ala599Pro Single submitter
- p.Glu497del Single submitter
- p.Glu505= Single submitter
- p.Gly207= Single submitter
- p.Gly23Asp Single submitter
- p.Leu19= Single submitter
- p.Leu238Phe Single submitter ⚠
- p.Ser67= Single submitter
- p.Tyr134= Single submitter
- c.30-14dup No assertion criteria
- c.334-10T>C No assertion criteria BRD2-related disorder
- p.Ala474Val No assertion criteria BRD2-related disorder
- p.Asp570= No assertion criteria BRD2-related disorder
- p.Lys31= No assertion criteria BRD2-related disorder
- p.Ser603= No assertion criteria BRD2-related disorder
Benign/Likely benign 2
- p.Ala766Thr Multiple submitters
- p.Ser397= Multiple submitters
Likely benign 18
- p.Gln533= Multiple submitters
- p.Leu383= Multiple submitters
- p.Val465= Multiple submitters
- c.1201-7T>C Single submitter
- c.1579-6C>T Single submitter
- c.826-6C>T Single submitter
- c.-1305+256del Single submitter
- p.Ala204= Single submitter
- p.Arg74= Single submitter
- p.Glu673= Single submitter
- p.Gly278= Single submitter
- p.His242= Single submitter
- p.Leu396= Single submitter
- p.Phe95= Single submitter
- p.Val163= Single submitter
- c.472-5C>T No assertion criteria BRD2-related disorder
- p.Lys751= No assertion criteria BRD2-related disorder
- p.Tyr153= No assertion criteria BRD2-related disorder
Uncertain significance 96
- p.Glu500del Multiple submitters
- p.Pro12Leu Multiple submitters ⚠
- p.Ala263Val Single submitter ⚠
- p.Ala295Pro Single submitter ⚠
- p.Ala295Ser Single submitter ⚠
- p.Ala310Thr Single submitter ⚠
- p.Ala378Val Single submitter ⚠
- p.Ala626Pro Single submitter ⚠
- p.Ala766Val Single submitter ⚠
- p.Arg312Pro Single submitter ⚠
- p.Arg312Trp Single submitter ⚠
- p.Arg406Cys Single submitter ⚠
- p.Arg409Gln Single submitter ⚠
- p.Arg566Gln Single submitter ⚠
- p.Arg701Cys Single submitter ⚠
- p.Arg708His Single submitter ⚠
- p.Arg734Gln Single submitter ⚠
- p.Arg739Gly Single submitter ⚠
- p.Arg773Cys Single submitter ⚠
- p.Asn133Ser Single submitter ⚠
- p.Asn77Ser Single submitter ⚠
- p.Asn9Asp Single submitter ⚠
- p.Asp410Glu Single submitter ⚠
- p.Asp570Asn Single submitter ⚠
- p.Asp570His Single submitter ⚠
- p.Asp794Gly Single submitter ⚠
- p.Asp799Glu Single submitter ⚠
- p.Gln175Glu Single submitter ⚠
- p.Gln214Pro Single submitter ⚠
- p.Gln271Lys Single submitter ⚠
- p.Gln337His Single submitter ⚠
- p.Gln412Arg Single submitter ⚠
- p.Gln55Pro Single submitter ⚠
- p.Glu14Ala Single submitter ⚠
- p.Glu459Gln Single submitter ⚠
- p.Glu500Asp Single submitter ⚠
- p.Glu505Gly Single submitter ⚠
- p.Glu522Lys Single submitter ⚠
- p.Glu532Asp Single submitter ⚠
- p.Glu646Asp Single submitter ⚠
- p.Glu762Gly Single submitter ⚠
- p.Gly18Ala Single submitter ⚠
- p.Gly801Asp Single submitter ⚠
- p.His213Tyr Single submitter ⚠
- p.His392Leu Single submitter ⚠
- p.His83Gln Single submitter ⚠
- p.Ile162Thr Single submitter ⚠
- p.Ile356Thr Single submitter ⚠
- p.Ile542Val Single submitter ⚠
- p.Leu250Phe Single submitter ⚠
- p.Leu262Phe Single submitter ⚠
- p.Leu273His Single submitter ⚠
- p.Leu313Pro Single submitter ⚠
- p.Leu704Phe Single submitter ⚠
- p.Leu774Phe Single submitter ⚠
- p.Leu82Pro Single submitter ⚠
- p.Lys329Glu Single submitter ⚠
- p.Lys555Arg Single submitter ⚠
- p.Met121Val Single submitter ⚠
- p.Met316Ile Single submitter ⚠
- p.Met394Lys Single submitter ⚠
- p.Met48Thr Single submitter ⚠
- p.Met48Val Single submitter ⚠
- p.Phe149Leu Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro158Ala Single submitter ⚠
- p.Pro249Ser Single submitter ⚠
- p.Pro259Ser Single submitter ⚠
- p.Pro260Leu Single submitter ⚠
- p.Pro269Ala Single submitter ⚠
- p.Pro269Ser Single submitter ⚠
- p.Pro323Ser Single submitter ⚠
- p.Pro431Ala Single submitter ⚠
- p.Pro471Arg Single submitter ⚠
- p.Pro576Leu Single submitter ⚠
- p.Pro579Ser Single submitter ⚠
- p.Pro58Arg Single submitter ⚠
- p.Pro58Ser Single submitter ⚠
- p.Pro641Leu Single submitter ⚠
- p.Pro674Thr Single submitter ⚠
- p.Pro711Leu Single submitter ⚠
- p.Pro753Thr Single submitter ⚠
- p.Pro7Ser Single submitter ⚠
- p.Ser486Asn Single submitter ⚠
- p.Ser490Phe Single submitter ⚠
- p.Ser510Pro Single submitter ⚠
- p.Ser591Asn Single submitter ⚠
- p.Ser597Ile Single submitter ⚠
- p.Ser785Cys Single submitter ⚠
- p.Ser786Cys Single submitter ⚠
- p.Ser796Thr Single submitter ⚠
- p.Thr467Ile Single submitter ⚠
- p.Thr57Asn Single submitter ⚠
- p.Thr750Ala Single submitter ⚠
- p.Tyr153Cys Single submitter ⚠
- p.Val85Ile Single submitter ⚠