Sugi Variant

Sugi Variant/BRD4

BRD4 — 922 ClinVar variants

All ClinVar germline BRD4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 374 flagged for review →

14 Pathogenic · 18 Likely pathogenic · 16 Conflicting · 72 Benign · 14 Benign/Likely benign · 380 Likely benign · 408 Uncertain significance

Full BRD4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 374

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 8

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 156

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 156

Predictors split 210

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 210

All BRD4 variants

Pathogenic 14

Likely pathogenic 18

Conflicting classifications of pathogenicity 16

Benign 72

Benign/Likely benign 14

Likely benign 380

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 408

Showing the top 300 by review status; the full set is in the sitemap.