BRINP3 — 98 ClinVar variants
All ClinVar germline BRINP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 97 flagged for review →
1 Likely benign · 97 Uncertain significance
Full BRINP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 97
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 58
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRINP3 p.Ala160Val Uncertain significance Single submitter
- BRINP3 p.Ala312Thr Uncertain significance Single submitter
- BRINP3 p.Arg112Ile Uncertain significance Single submitter
- BRINP3 p.Arg116Cys Uncertain significance Single submitter
- BRINP3 p.Arg305Gln Uncertain significance Single submitter
- BRINP3 p.Arg354His Uncertain significance Single submitter
- BRINP3 p.Arg395Ser Uncertain significance Single submitter
- BRINP3 p.Arg56His Uncertain significance Single submitter
- BRINP3 p.Arg68Leu Uncertain significance Single submitter
- BRINP3 p.Asn168Ser Uncertain significance Single submitter
- BRINP3 p.Asn276Asp Uncertain significance Single submitter
- BRINP3 p.Asn360Lys Uncertain significance Single submitter
- BRINP3 p.Asn464His Uncertain significance Single submitter
- BRINP3 p.Asn636Asp Uncertain significance Single submitter
- BRINP3 p.Asn636Ile Uncertain significance Single submitter
- BRINP3 p.Asn664Ser Uncertain significance Single submitter
- BRINP3 p.Asp65Asn Uncertain significance Single submitter
- BRINP3 p.Asp676Tyr Uncertain significance Single submitter
- BRINP3 p.Gln357Lys Uncertain significance Single submitter
- BRINP3 p.Gln38Arg Uncertain significance Single submitter
- BRINP3 p.Gln606Lys Uncertain significance Single submitter
- BRINP3 p.Gly461Ser Uncertain significance Single submitter
- BRINP3 p.Gly472Glu Uncertain significance Single submitter
- BRINP3 p.Gly70Arg Uncertain significance Single submitter
- BRINP3 p.His424Asn Uncertain significance Single submitter
- BRINP3 p.Ile111Val Uncertain significance Single submitter
- BRINP3 p.Ile296Val Uncertain significance Single submitter
- BRINP3 p.Ile666Leu Uncertain significance Single submitter
- BRINP3 p.Ile680Val Uncertain significance Single submitter
- BRINP3 p.Leu113Pro Uncertain significance Single submitter
- BRINP3 p.Leu137Val Uncertain significance Single submitter
- BRINP3 p.Leu174Gln Uncertain significance Single submitter
- BRINP3 p.Leu388Ile Uncertain significance Single submitter
- BRINP3 p.Lys285Arg Uncertain significance Single submitter
- BRINP3 p.Lys600Arg Uncertain significance Single submitter
- BRINP3 p.Met342Val Uncertain significance Single submitter
- BRINP3 p.Met347Lys Uncertain significance Single submitter
- BRINP3 p.Met468Val Uncertain significance Single submitter
- BRINP3 p.Phe317Ser Uncertain significance Single submitter
- BRINP3 p.Phe366Leu Uncertain significance Single submitter
- BRINP3 p.Phe377Tyr Uncertain significance Single submitter
- BRINP3 p.Pro392Gln Uncertain significance Single submitter
- BRINP3 p.Pro429Ala Uncertain significance Single submitter
- BRINP3 p.Pro43Thr Uncertain significance Single submitter
- BRINP3 p.Pro476Ala Uncertain significance Single submitter
- BRINP3 p.Pro677Ser Uncertain significance Single submitter
- BRINP3 p.Ser339Thr Uncertain significance Single submitter
- BRINP3 p.Ser361Asn Uncertain significance Single submitter
- BRINP3 p.Ser544Ala Uncertain significance Single submitter
- BRINP3 p.Ser5Cys Uncertain significance Single submitter
- BRINP3 p.Ser67Ile Uncertain significance Single submitter
- BRINP3 p.Thr402Ile Uncertain significance Single submitter
- BRINP3 p.Thr756Lys Uncertain significance Single submitter
- BRINP3 p.Trp18Cys Uncertain significance Single submitter
- BRINP3 p.Trp3Arg Uncertain significance Single submitter
- BRINP3 p.Tyr78Cys Uncertain significance Single submitter
- BRINP3 p.Val231Ala Uncertain significance Single submitter
- BRINP3 p.Val91Leu Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- BRINP3 p.Ala33Pro Uncertain significance Single submitter
- BRINP3 p.Ala34Asp Uncertain significance Single submitter
- BRINP3 p.Arg109Ser Uncertain significance Single submitter
- BRINP3 p.Arg116His Uncertain significance Single submitter
- BRINP3 p.Arg56Cys Uncertain significance Single submitter
- BRINP3 p.Arg729Leu Uncertain significance Single submitter
- BRINP3 p.Arg94Ser Uncertain significance Single submitter
- BRINP3 p.Asn266His Uncertain significance Single submitter
- BRINP3 p.Asn290Asp Uncertain significance Single submitter
- BRINP3 p.Asn464Ile Uncertain significance Single submitter
- BRINP3 p.Asn88Asp Uncertain significance Single submitter
- BRINP3 p.Asp189His Uncertain significance Single submitter
- BRINP3 p.Asp221Asn Uncertain significance Single submitter
- BRINP3 p.Asp321Gly Uncertain significance Single submitter
- BRINP3 p.Asp348Glu Uncertain significance Single submitter
- BRINP3 p.Asp688Glu Uncertain significance Single submitter
- BRINP3 p.Asp688His Uncertain significance Single submitter
- BRINP3 p.Glu319Val Uncertain significance Single submitter
- BRINP3 p.Ile633Asn Uncertain significance Single submitter
- BRINP3 p.Leu113Val Uncertain significance Single submitter
- BRINP3 p.Leu240Phe Uncertain significance Single submitter
- BRINP3 p.Leu243Phe Uncertain significance Single submitter
- BRINP3 p.Leu365Val Uncertain significance Single submitter
- BRINP3 p.Leu450Pro Uncertain significance Single submitter
- BRINP3 p.Leu469Phe Uncertain significance Single submitter
- BRINP3 p.Leu605Pro Uncertain significance Single submitter
- BRINP3 p.Leu713Arg Uncertain significance Single submitter
- BRINP3 p.Lys328Asn Uncertain significance Single submitter
- BRINP3 p.Pro476Ser Uncertain significance Single submitter
- BRINP3 p.Pro53Ser Uncertain significance Single submitter
- BRINP3 p.Pro754Gln Uncertain significance Single submitter
- BRINP3 p.Ser169Arg Uncertain significance Single submitter
- BRINP3 p.Ser171Trp Uncertain significance Single submitter
- BRINP3 p.Ser72Asn Uncertain significance Single submitter
- BRINP3 p.Thr119Ala Uncertain significance Single submitter
- BRINP3 p.Thr73Ala Uncertain significance Single submitter
- BRINP3 p.Trp618Leu Uncertain significance Single submitter
- BRINP3 p.Tyr646Cys Uncertain significance Single submitter
- BRINP3 p.Val547Ala Uncertain significance Single submitter
All BRINP3 variants
Likely benign 1
- p.Asn636Ser Single submitter
Uncertain significance 97
- p.Ala160Val Single submitter ⚠
- p.Ala312Thr Single submitter ⚠
- p.Ala33Pro Single submitter ⚠
- p.Ala34Asp Single submitter ⚠
- p.Arg109Ser Single submitter ⚠
- p.Arg112Ile Single submitter ⚠
- p.Arg116Cys Single submitter ⚠
- p.Arg116His Single submitter ⚠
- p.Arg305Gln Single submitter ⚠
- p.Arg354His Single submitter ⚠
- p.Arg395Ser Single submitter ⚠
- p.Arg56Cys Single submitter ⚠
- p.Arg56His Single submitter ⚠
- p.Arg68Leu Single submitter ⚠
- p.Arg729Leu Single submitter ⚠
- p.Arg94Ser Single submitter ⚠
- p.Asn168Ser Single submitter ⚠
- p.Asn266His Single submitter ⚠
- p.Asn276Asp Single submitter ⚠
- p.Asn290Asp Single submitter ⚠
- p.Asn360Lys Single submitter ⚠
- p.Asn464His Single submitter ⚠
- p.Asn464Ile Single submitter ⚠
- p.Asn636Asp Single submitter ⚠
- p.Asn636Ile Single submitter ⚠
- p.Asn664Ser Single submitter ⚠
- p.Asn88Asp Single submitter ⚠
- p.Asp189His Single submitter ⚠
- p.Asp221Asn Single submitter ⚠
- p.Asp321Gly Single submitter ⚠
- p.Asp348Glu Single submitter ⚠
- p.Asp65Asn Single submitter ⚠
- p.Asp676Tyr Single submitter ⚠
- p.Asp688Glu Single submitter ⚠
- p.Asp688His Single submitter ⚠
- p.Gln357Lys Single submitter ⚠
- p.Gln38Arg Single submitter ⚠
- p.Gln606Lys Single submitter ⚠
- p.Glu319Val Single submitter ⚠
- p.Gly461Ser Single submitter ⚠
- p.Gly472Glu Single submitter ⚠
- p.Gly70Arg Single submitter ⚠
- p.His424Asn Single submitter ⚠
- p.Ile111Val Single submitter ⚠
- p.Ile296Val Single submitter ⚠
- p.Ile633Asn Single submitter ⚠
- p.Ile666Leu Single submitter ⚠
- p.Ile680Val Single submitter ⚠
- p.Leu113Pro Single submitter ⚠
- p.Leu113Val Single submitter ⚠
- p.Leu137Val Single submitter ⚠
- p.Leu174Gln Single submitter ⚠
- p.Leu240Phe Single submitter ⚠
- p.Leu243Phe Single submitter ⚠
- p.Leu365Val Single submitter ⚠
- p.Leu388Ile Single submitter ⚠
- p.Leu450Pro Single submitter ⚠
- p.Leu469Phe Single submitter ⚠
- p.Leu605Pro Single submitter ⚠
- p.Leu713Arg Single submitter ⚠
- p.Lys285Arg Single submitter ⚠
- p.Lys328Asn Single submitter ⚠
- p.Lys600Arg Single submitter ⚠
- p.Met342Val Single submitter ⚠
- p.Met347Lys Single submitter ⚠
- p.Met468Val Single submitter ⚠
- p.Phe317Ser Single submitter ⚠
- p.Phe366Leu Single submitter ⚠
- p.Phe377Tyr Single submitter ⚠
- p.Pro392Gln Single submitter ⚠
- p.Pro429Ala Single submitter ⚠
- p.Pro43Thr Single submitter ⚠
- p.Pro476Ala Single submitter ⚠
- p.Pro476Ser Single submitter ⚠
- p.Pro53Ser Single submitter ⚠
- p.Pro677Ser Single submitter ⚠
- p.Pro754Gln Single submitter ⚠
- p.Ser169Arg Single submitter ⚠
- p.Ser171Trp Single submitter ⚠
- p.Ser339Thr Single submitter ⚠
- p.Ser361Asn Single submitter ⚠
- p.Ser544Ala Single submitter ⚠
- p.Ser5Cys Single submitter ⚠
- p.Ser67Ile Single submitter ⚠
- p.Ser72Asn Single submitter ⚠
- p.Thr119Ala Single submitter ⚠
- p.Thr402Ile Single submitter ⚠
- p.Thr73Ala Single submitter ⚠
- p.Thr756Lys Single submitter ⚠
- p.Trp18Cys Single submitter ⚠
- p.Trp3Arg Single submitter ⚠
- p.Trp618Leu Single submitter ⚠
- p.Tyr646Cys Single submitter ⚠
- p.Tyr78Cys Single submitter ⚠
- p.Val231Ala Single submitter ⚠
- p.Val547Ala Single submitter ⚠
- p.Val91Leu Single submitter ⚠