BROX — 42 ClinVar variants
All ClinVar germline BROX variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
2 Benign · 1 Likely benign · 39 Uncertain significance
Full BROX gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BROX p.Ala191Val Uncertain significance Single submitter
- BROX p.Ala213Val Uncertain significance Single submitter
- BROX p.Arg178Gln Uncertain significance Single submitter
- BROX p.Arg378Lys Uncertain significance Single submitter
- BROX p.Asn19Ser Uncertain significance Single submitter
- BROX p.Asn218Ser Uncertain significance Single submitter
- BROX p.Asp76Gly Uncertain significance Single submitter
- BROX p.Glu181Gly Uncertain significance Single submitter
- BROX p.Glu357Ala Uncertain significance Single submitter
- BROX p.His225Arg Uncertain significance Single submitter
- BROX p.His306Tyr Uncertain significance Single submitter
- BROX p.Ile200Leu Uncertain significance Single submitter
- BROX p.Ile200Val Uncertain significance Single submitter
- BROX p.Leu280Ser Uncertain significance Single submitter
- BROX p.Leu50Val Uncertain significance Single submitter
- BROX p.Leu96Trp Uncertain significance Single submitter
- BROX p.Lys11Glu Uncertain significance Single submitter
- BROX p.Lys245Thr Uncertain significance Single submitter
- BROX p.Lys91Arg Uncertain significance Single submitter
- BROX p.Pro394Thr Uncertain significance Single submitter
- BROX p.Ser113Tyr Uncertain significance Single submitter
- BROX p.Ser74Thr Uncertain significance Single submitter
- BROX p.Thr337Ala Uncertain significance Single submitter
- BROX p.Tyr281Phe Uncertain significance Single submitter
- BROX p.Tyr291Cys Uncertain significance Single submitter
- BROX p.Val395Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- BROX p.Ala169Val Uncertain significance Single submitter
- BROX p.Asn117Ser Uncertain significance Single submitter
- BROX p.Glu142Val Uncertain significance Single submitter
- BROX p.Glu170Val Uncertain significance Single submitter
- BROX p.Gly207Glu Uncertain significance Single submitter
- BROX p.Ile180Thr Uncertain significance Single submitter
- BROX p.Leu46Val Uncertain significance Single submitter
- BROX p.Lys387Arg Uncertain significance Single submitter
- BROX p.Phe356Val Uncertain significance Single submitter
- BROX p.Pro9Ala Uncertain significance Single submitter
- BROX p.Ser78Cys Uncertain significance Single submitter
- BROX p.Thr250Pro Uncertain significance Single submitter
- BROX p.Val351Ile Uncertain significance Single submitter
All BROX variants
Benign 2
- p.Ala169= Single submitter
- p.Pro54Thr Single submitter
Likely benign 1
- p.Asn134= Single submitter
Uncertain significance 39
- p.Ala169Val Single submitter ⚠
- p.Ala191Val Single submitter ⚠
- p.Ala213Val Single submitter ⚠
- p.Arg178Gln Single submitter ⚠
- p.Arg378Lys Single submitter ⚠
- p.Asn117Ser Single submitter ⚠
- p.Asn19Ser Single submitter ⚠
- p.Asn218Ser Single submitter ⚠
- p.Asp76Gly Single submitter ⚠
- p.Glu142Val Single submitter ⚠
- p.Glu170Val Single submitter ⚠
- p.Glu181Gly Single submitter ⚠
- p.Glu357Ala Single submitter ⚠
- p.Gly207Glu Single submitter ⚠
- p.His225Arg Single submitter ⚠
- p.His306Tyr Single submitter ⚠
- p.Ile180Thr Single submitter ⚠
- p.Ile200Leu Single submitter ⚠
- p.Ile200Val Single submitter ⚠
- p.Leu280Ser Single submitter ⚠
- p.Leu46Val Single submitter ⚠
- p.Leu50Val Single submitter ⚠
- p.Leu96Trp Single submitter ⚠
- p.Lys11Glu Single submitter ⚠
- p.Lys245Thr Single submitter ⚠
- p.Lys387Arg Single submitter ⚠
- p.Lys91Arg Single submitter ⚠
- p.Phe356Val Single submitter ⚠
- p.Pro394Thr Single submitter ⚠
- p.Pro9Ala Single submitter ⚠
- p.Ser113Tyr Single submitter ⚠
- p.Ser74Thr Single submitter ⚠
- p.Ser78Cys Single submitter ⚠
- p.Thr250Pro Single submitter ⚠
- p.Thr337Ala Single submitter ⚠
- p.Tyr281Phe Single submitter ⚠
- p.Tyr291Cys Single submitter ⚠
- p.Val351Ile Single submitter ⚠
- p.Val395Met Single submitter ⚠