CA13 — 34 ClinVar variants
All ClinVar germline CA13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Benign · 2 Likely benign · 31 Uncertain significance
Full CA13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CA13 p.Ala143Pro Uncertain significance Single submitter
- CA13 p.Ala240Thr Uncertain significance Single submitter
- CA13 p.Arg247His Uncertain significance Single submitter
- CA13 p.Arg255Cys Uncertain significance Single submitter
- CA13 p.Arg81His Uncertain significance Single submitter
- CA13 p.Arg9Cys Uncertain significance Single submitter
- CA13 p.Asn245Asp Uncertain significance Single submitter
- CA13 p.Gln28His Uncertain significance Single submitter
- CA13 p.Glu107Lys Uncertain significance Single submitter
- CA13 p.Gly64Ser Uncertain significance Single submitter
- CA13 p.Gly83Ser Uncertain significance Single submitter
- CA13 p.Leu149Ser Uncertain significance Single submitter
- CA13 p.Leu183Phe Uncertain significance Single submitter
- CA13 p.Pro249Leu Uncertain significance Single submitter
- CA13 p.Pro31Ala Uncertain significance Single submitter
- CA13 p.Pro84Thr Uncertain significance Single submitter
- CA13 p.Ser5Thr Uncertain significance Single submitter
- CA13 p.Thr162Ile Uncertain significance Single submitter
- CA13 p.Thr233Ser Uncertain significance Single submitter
- CA13 p.Tyr89Cys Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CA13 p.Ala234Gly Uncertain significance Single submitter
- CA13 p.Gly254Val Uncertain significance Single submitter
- CA13 p.Gly82Asp Uncertain significance Single submitter
- CA13 p.Ile161Val Uncertain significance Single submitter
- CA13 p.Ile217Thr Uncertain significance Single submitter
- CA13 p.Pro251Ser Uncertain significance Single submitter
- CA13 p.Ser207Thr Uncertain significance Single submitter
- CA13 p.Ser244Ile Uncertain significance Single submitter
- CA13 p.Tyr115Cys Uncertain significance Single submitter
- CA13 p.Val201Phe Uncertain significance Single submitter
- CA13 p.Val39Met Uncertain significance Single submitter
All CA13 variants
Benign 1
- p.Gly152= Single submitter
Likely benign 2
- p.Asn68Ser Single submitter
- p.His262Arg Single submitter
Uncertain significance 31
- p.Ala143Pro Single submitter ⚠
- p.Ala234Gly Single submitter ⚠
- p.Ala240Thr Single submitter ⚠
- p.Arg247His Single submitter ⚠
- p.Arg255Cys Single submitter ⚠
- p.Arg81His Single submitter ⚠
- p.Arg9Cys Single submitter ⚠
- p.Asn245Asp Single submitter ⚠
- p.Gln28His Single submitter ⚠
- p.Glu107Lys Single submitter ⚠
- p.Gly254Val Single submitter ⚠
- p.Gly64Ser Single submitter ⚠
- p.Gly82Asp Single submitter ⚠
- p.Gly83Ser Single submitter ⚠
- p.Ile161Val Single submitter ⚠
- p.Ile217Thr Single submitter ⚠
- p.Leu149Ser Single submitter ⚠
- p.Leu183Phe Single submitter ⚠
- p.Pro249Leu Single submitter ⚠
- p.Pro251Ser Single submitter ⚠
- p.Pro31Ala Single submitter ⚠
- p.Pro84Thr Single submitter ⚠
- p.Ser207Thr Single submitter ⚠
- p.Ser244Ile Single submitter ⚠
- p.Ser5Thr Single submitter ⚠
- p.Thr162Ile Single submitter ⚠
- p.Thr233Ser Single submitter ⚠
- p.Tyr115Cys Single submitter ⚠
- p.Tyr89Cys Single submitter ⚠
- p.Val201Phe Single submitter ⚠
- p.Val39Met Single submitter ⚠