CA14 — 64 ClinVar variants
All ClinVar germline CA14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
2 Benign · 4 Likely benign · 58 Uncertain significance
Full CA14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CA14 p.Arg211Gly Uncertain significance Single submitter
- CA14 p.Arg232Gly Uncertain significance Single submitter
- CA14 p.Arg264Gln Uncertain significance Single submitter
- CA14 p.Arg313Lys Uncertain significance Single submitter
- CA14 p.Arg323Gln Uncertain significance Single submitter
- CA14 p.Asn213Ser Uncertain significance Single submitter
- CA14 p.Asn270His Uncertain significance Single submitter
- CA14 p.Asp78Tyr Uncertain significance Single submitter
- CA14 p.Cys221Gly Uncertain significance Single submitter
- CA14 p.Cys40Arg Uncertain significance Single submitter
- CA14 p.Cys40Tyr Uncertain significance Single submitter
- CA14 p.Gln271Arg Uncertain significance Single submitter
- CA14 p.Gln65Lys Uncertain significance Single submitter
- CA14 p.Glu75Ala Uncertain significance Single submitter
- CA14 p.Gly113Val Uncertain significance Single submitter
- CA14 p.His21Pro Uncertain significance Single submitter
- CA14 p.His84Asn Uncertain significance Single submitter
- CA14 p.Ile172Thr Uncertain significance Single submitter
- CA14 p.Ile177Leu Uncertain significance Single submitter
- CA14 p.Leu160Pro Uncertain significance Single submitter
- CA14 p.Leu201Arg Uncertain significance Single submitter
- CA14 p.Lys317Arg Uncertain significance Single submitter
- CA14 p.Met238Ile Uncertain significance Single submitter
- CA14 p.Ser141Pro Uncertain significance Single submitter
- CA14 p.Ser292Thr Uncertain significance Single submitter
- CA14 p.Ser46Leu Uncertain significance Single submitter
- CA14 p.Thr74Ser Uncertain significance Single submitter
- CA14 p.Thr85Pro Uncertain significance Single submitter
- CA14 p.Trp12Cys Uncertain significance Single submitter
- CA14 p.Val295Ile Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CA14 p.Ala158Gly Uncertain significance Single submitter
- CA14 p.Ala173Val Uncertain significance Single submitter
- CA14 p.Arg101Gln Uncertain significance Single submitter
- CA14 p.Arg211His Uncertain significance Single submitter
- CA14 p.Arg272His Uncertain significance Single submitter
- CA14 p.Arg319Gly Uncertain significance Single submitter
- CA14 p.Asn82Ser Uncertain significance Single submitter
- CA14 p.Glu200Lys Uncertain significance Single submitter
- CA14 p.Glu239Gln Uncertain significance Single submitter
- CA14 p.Gly68Arg Uncertain significance Single submitter
- CA14 p.Ile164Thr Uncertain significance Single submitter
- CA14 p.Ile311Met Uncertain significance Single submitter
- CA14 p.Leu134Phe Uncertain significance Single submitter
- CA14 p.Leu7Pro Uncertain significance Single submitter
- CA14 p.Leu88Phe Uncertain significance Single submitter
- CA14 p.Leu8Pro Uncertain significance Single submitter
- CA14 p.Lys102Thr Uncertain significance Single submitter
- CA14 p.Pro34Thr Uncertain significance Single submitter
- CA14 p.Pro59Thr Uncertain significance Single submitter
- CA14 p.Ser143Phe Uncertain significance Single submitter
- CA14 p.Ser148Asn Uncertain significance Single submitter
- CA14 p.Ser224Gly Uncertain significance Single submitter
- CA14 p.Ser234Tyr Uncertain significance Single submitter
- CA14 p.Ser283Phe Uncertain significance Single submitter
- CA14 p.Ser325Cys Uncertain significance Single submitter
- CA14 p.Thr251Lys Uncertain significance Single submitter
- CA14 p.Thr93Ile Uncertain significance Single submitter
- CA14 p.Tyr24Phe Uncertain significance Single submitter
All CA14 variants
Benign 2
- p.Glu149= Multiple submitters
- p.Ala312Thr Single submitter
Likely benign 4
- c.863-4C>T Single submitter
- p.Asp49Asn Single submitter
- p.Met238Thr Single submitter
- p.Met273Thr Single submitter
Uncertain significance 58
- p.Ala158Gly Single submitter ⚠
- p.Ala173Val Single submitter ⚠
- p.Arg101Gln Single submitter ⚠
- p.Arg211Gly Single submitter ⚠
- p.Arg211His Single submitter ⚠
- p.Arg232Gly Single submitter ⚠
- p.Arg264Gln Single submitter ⚠
- p.Arg272His Single submitter ⚠
- p.Arg313Lys Single submitter ⚠
- p.Arg319Gly Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Asn213Ser Single submitter ⚠
- p.Asn270His Single submitter ⚠
- p.Asn82Ser Single submitter ⚠
- p.Asp78Tyr Single submitter ⚠
- p.Cys221Gly Single submitter ⚠
- p.Cys40Arg Single submitter ⚠
- p.Cys40Tyr Single submitter ⚠
- p.Gln271Arg Single submitter ⚠
- p.Gln65Lys Single submitter ⚠
- p.Glu200Lys Single submitter ⚠
- p.Glu239Gln Single submitter ⚠
- p.Glu75Ala Single submitter ⚠
- p.Gly113Val Single submitter ⚠
- p.Gly68Arg Single submitter ⚠
- p.His21Pro Single submitter ⚠
- p.His84Asn Single submitter ⚠
- p.Ile164Thr Single submitter ⚠
- p.Ile172Thr Single submitter ⚠
- p.Ile177Leu Single submitter ⚠
- p.Ile311Met Single submitter ⚠
- p.Leu134Phe Single submitter ⚠
- p.Leu160Pro Single submitter ⚠
- p.Leu201Arg Single submitter ⚠
- p.Leu7Pro Single submitter ⚠
- p.Leu88Phe Single submitter ⚠
- p.Leu8Pro Single submitter ⚠
- p.Lys102Thr Single submitter ⚠
- p.Lys317Arg Single submitter ⚠
- p.Met238Ile Single submitter ⚠
- p.Pro34Thr Single submitter ⚠
- p.Pro59Thr Single submitter ⚠
- p.Ser141Pro Single submitter ⚠
- p.Ser143Phe Single submitter ⚠
- p.Ser148Asn Single submitter ⚠
- p.Ser224Gly Single submitter ⚠
- p.Ser234Tyr Single submitter ⚠
- p.Ser283Phe Single submitter ⚠
- p.Ser292Thr Single submitter ⚠
- p.Ser325Cys Single submitter ⚠
- p.Ser46Leu Single submitter ⚠
- p.Thr251Lys Single submitter ⚠
- p.Thr74Ser Single submitter ⚠
- p.Thr85Pro Single submitter ⚠
- p.Thr93Ile Single submitter ⚠
- p.Trp12Cys Single submitter ⚠
- p.Tyr24Phe Single submitter ⚠
- p.Val295Ile Single submitter ⚠