CA3 — 19 ClinVar variants
All ClinVar germline CA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
19 Uncertain significance
Full CA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CA3 p.Ala115Glu Uncertain significance Single submitter
- CA3 p.Arg188Gln Uncertain significance Single submitter
- CA3 p.Asp179Gly Uncertain significance Single submitter
- CA3 p.Glu26Gln Uncertain significance Single submitter
- CA3 p.Gly82Cys Uncertain significance Single submitter
- CA3 p.Gly82Ser Uncertain significance Single submitter
- CA3 p.His10Tyr Uncertain significance Single submitter
- CA3 p.His151Asp Uncertain significance Single submitter
- CA3 p.His96Arg Uncertain significance Single submitter
- CA3 p.Ile149Leu Uncertain significance Single submitter
- CA3 p.Ile206Thr Uncertain significance Single submitter
- CA3 p.Ile250Val Uncertain significance Single submitter
- CA3 p.Trp123Arg Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CA3 p.Ala232Thr Uncertain significance Single submitter
- CA3 p.Asn62Ser Uncertain significance Single submitter
- CA3 p.His15Tyr Uncertain significance Single submitter
- CA3 p.Lys126Asn Uncertain significance Single submitter
- CA3 p.Lys224Arg Uncertain significance Single submitter
- CA3 p.Pro21Leu Uncertain significance Single submitter
All CA3 variants
Uncertain significance 19
- p.Ala115Glu Single submitter ⚠
- p.Ala232Thr Single submitter ⚠
- p.Arg188Gln Single submitter ⚠
- p.Asn62Ser Single submitter ⚠
- p.Asp179Gly Single submitter ⚠
- p.Glu26Gln Single submitter ⚠
- p.Gly82Cys Single submitter ⚠
- p.Gly82Ser Single submitter ⚠
- p.His10Tyr Single submitter ⚠
- p.His151Asp Single submitter ⚠
- p.His15Tyr Single submitter ⚠
- p.His96Arg Single submitter ⚠
- p.Ile149Leu Single submitter ⚠
- p.Ile206Thr Single submitter ⚠
- p.Ile250Val Single submitter ⚠
- p.Lys126Asn Single submitter ⚠
- p.Lys224Arg Single submitter ⚠
- p.Pro21Leu Single submitter ⚠
- p.Trp123Arg Single submitter ⚠