CALCB — 31 ClinVar variants
All ClinVar germline CALCB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
3 Likely benign · 28 Uncertain significance
Full CALCB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALCB p.Ala127Asp Uncertain significance Single submitter
- CALCB p.Ala77Gly Uncertain significance Single submitter
- CALCB p.Asn112Ser Uncertain significance Single submitter
- CALCB p.Gln24Arg Uncertain significance Single submitter
- CALCB p.Gln69Pro Uncertain significance Single submitter
- CALCB p.Gln72Lys Uncertain significance Single submitter
- CALCB p.Gly73Ser Uncertain significance Single submitter
- CALCB p.Lys66Asn Uncertain significance Single submitter
- CALCB p.Lys66Gln Uncertain significance Single submitter
- CALCB p.Lys80Asn Uncertain significance Single submitter
- CALCB p.Pro38Leu Uncertain significance Single submitter
- CALCB p.Pro8Leu Uncertain significance Single submitter
- CALCB p.Ser34Arg Uncertain significance Single submitter
- CALCB p.Val113Gly Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CALCB p.Ala117Asp Uncertain significance Single submitter
- CALCB p.Ala46Thr Uncertain significance Single submitter
- CALCB p.Arg121Cys Uncertain significance Single submitter
- CALCB p.Arg121His Uncertain significance Single submitter
- CALCB p.Arg122Cys Uncertain significance Single submitter
- CALCB p.Arg122His Uncertain significance Single submitter
- CALCB p.Arg123Ser Uncertain significance Single submitter
- CALCB p.Arg92Gln Uncertain significance Single submitter
- CALCB p.Arg92Trp Uncertain significance Single submitter
- CALCB p.Asn112Asp Likely benign Single submitter
- CALCB p.Asp124Asn Uncertain significance Single submitter
- CALCB p.Glu44Asp Uncertain significance Single submitter
- CALCB p.Glu70Lys Uncertain significance Single submitter
- CALCB p.Leu96Val Uncertain significance Single submitter
- CALCB p.Phe118Val Uncertain significance Single submitter
All CALCB variants
Likely benign 3
- p.Arg29= Single submitter
- p.Asn112Asp Single submitter ⚠
- p.Ser63Asn Single submitter
Uncertain significance 28
- p.Ala117Asp Single submitter ⚠
- p.Ala127Asp Single submitter ⚠
- p.Ala46Thr Single submitter ⚠
- p.Ala77Gly Single submitter ⚠
- p.Arg121Cys Single submitter ⚠
- p.Arg121His Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Arg122His Single submitter ⚠
- p.Arg123Ser Single submitter ⚠
- p.Arg92Gln Single submitter ⚠
- p.Arg92Trp Single submitter ⚠
- p.Asn112Ser Single submitter ⚠
- p.Asp124Asn Single submitter ⚠
- p.Gln24Arg Single submitter ⚠
- p.Gln69Pro Single submitter ⚠
- p.Gln72Lys Single submitter ⚠
- p.Glu44Asp Single submitter ⚠
- p.Glu70Lys Single submitter ⚠
- p.Gly73Ser Single submitter ⚠
- p.Leu96Val Single submitter ⚠
- p.Lys66Asn Single submitter ⚠
- p.Lys66Gln Single submitter ⚠
- p.Lys80Asn Single submitter ⚠
- p.Phe118Val Single submitter ⚠
- p.Pro38Leu Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Ser34Arg Single submitter ⚠
- p.Val113Gly Single submitter ⚠