CALML3 — 26 ClinVar variants
All ClinVar germline CALML3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
1 Likely benign · 25 Uncertain significance
Full CALML3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALML3 p.Ala89Asp Uncertain significance Single submitter
- CALML3 p.Arg58Gln Uncertain significance Single submitter
- CALML3 p.Asn43Asp Uncertain significance Single submitter
- CALML3 p.Gly114Arg Uncertain significance Single submitter
- CALML3 p.Lys14Asn Uncertain significance Single submitter
- CALML3 p.Met72Lys Uncertain significance Single submitter
- CALML3 p.Val109Ile Uncertain significance Single submitter
- CALML3 p.Val143Asp Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CALML3 p.Arg107Gln Uncertain significance Single submitter
- CALML3 p.Arg31Cys Uncertain significance Single submitter
- CALML3 p.Arg58Trp Uncertain significance Single submitter
- CALML3 p.Arg91Cys Uncertain significance Single submitter
- CALML3 p.Arg91His Uncertain significance Single submitter
- CALML3 p.Glu115Asp Uncertain significance Single submitter
- CALML3 p.Glu140Asp Uncertain significance Single submitter
- CALML3 p.Glu55Gly Uncertain significance Single submitter
- CALML3 p.Glu7Lys Uncertain significance Single submitter
- CALML3 p.Glu83Lys Uncertain significance Single submitter
- CALML3 p.Glu85Gln Uncertain significance Single submitter
- CALML3 p.Gly71Asp Uncertain significance Single submitter
- CALML3 p.Gly97Asp Uncertain significance Single submitter
- CALML3 p.Ile28Leu Uncertain significance Single submitter
- CALML3 p.Ser148Phe Uncertain significance Single submitter
- CALML3 p.Thr111Asn Uncertain significance Single submitter
- CALML3 p.Val10Leu Uncertain significance Single submitter
All CALML3 variants
Likely benign 1
- p.Val145Met Single submitter
Uncertain significance 25
- p.Ala89Asp Single submitter ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg31Cys Single submitter ⚠
- p.Arg58Gln Single submitter ⚠
- p.Arg58Trp Single submitter ⚠
- p.Arg91Cys Single submitter ⚠
- p.Arg91His Single submitter ⚠
- p.Asn43Asp Single submitter ⚠
- p.Glu115Asp Single submitter ⚠
- p.Glu140Asp Single submitter ⚠
- p.Glu55Gly Single submitter ⚠
- p.Glu7Lys Single submitter ⚠
- p.Glu83Lys Single submitter ⚠
- p.Glu85Gln Single submitter ⚠
- p.Gly114Arg Single submitter ⚠
- p.Gly71Asp Single submitter ⚠
- p.Gly97Asp Single submitter ⚠
- p.Ile28Leu Single submitter ⚠
- p.Lys14Asn Single submitter ⚠
- p.Met72Lys Single submitter ⚠
- p.Ser148Phe Single submitter ⚠
- p.Thr111Asn Single submitter ⚠
- p.Val109Ile Single submitter ⚠
- p.Val10Leu Single submitter ⚠
- p.Val143Asp Single submitter ⚠