CALN1 — 27 ClinVar variants
All ClinVar germline CALN1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
2 Benign · 25 Uncertain significance
Full CALN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CALN1 p.Ala65Val Uncertain significance Single submitter
- CALN1 p.Arg187Gln Uncertain significance Single submitter
- CALN1 p.Asn201Ser Uncertain significance Single submitter
- CALN1 p.Asp127Glu Uncertain significance Single submitter
- CALN1 p.Gln101Pro Uncertain significance Single submitter
- CALN1 p.Glu204Gln Uncertain significance Single submitter
- CALN1 p.Gly152Ser Uncertain significance Single submitter
- CALN1 p.Gly51Ser Uncertain significance Single submitter
- CALN1 p.Ile161Val Uncertain significance Single submitter
- CALN1 p.Ile75Val Uncertain significance Single submitter
- CALN1 p.Met140Leu Uncertain significance Single submitter
- CALN1 p.Pro29Leu Uncertain significance Single submitter
- CALN1 p.Ser163Gly Uncertain significance Single submitter
- CALN1 p.Ser210Leu Uncertain significance Single submitter
- CALN1 p.Ser62Leu Uncertain significance Single submitter
- CALN1 p.Ser69Asn Uncertain significance Single submitter
- CALN1 p.Ser69Gly Uncertain significance Single submitter
- CALN1 p.Tyr183Cys Uncertain significance Single submitter
- CALN1 p.Tyr54Phe Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CALN1 p.Ala50Val Uncertain significance Single submitter
- CALN1 p.Arg232Trp Uncertain significance Single submitter
- CALN1 p.Glu203Lys Uncertain significance Single submitter
- CALN1 p.Tyr183Ser Uncertain significance Single submitter
- CALN1 p.Tyr54Cys Uncertain significance Single submitter
- CALN1 p.Val77Met Uncertain significance Single submitter
All CALN1 variants
Benign 2
- c.658+8C>A Single submitter
- p.Gly111= Single submitter
Uncertain significance 25
- p.Ala50Val Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Arg187Gln Single submitter ⚠
- p.Arg232Trp Single submitter ⚠
- p.Asn201Ser Single submitter ⚠
- p.Asp127Glu Single submitter ⚠
- p.Gln101Pro Single submitter ⚠
- p.Glu203Lys Single submitter ⚠
- p.Glu204Gln Single submitter ⚠
- p.Gly152Ser Single submitter ⚠
- p.Gly51Ser Single submitter ⚠
- p.Ile161Val Single submitter ⚠
- p.Ile75Val Single submitter ⚠
- p.Met140Leu Single submitter ⚠
- p.Pro29Leu Single submitter ⚠
- p.Ser163Gly Single submitter ⚠
- p.Ser210Leu Single submitter ⚠
- p.Ser62Leu Single submitter ⚠
- p.Ser69Asn Single submitter ⚠
- p.Ser69Gly Single submitter ⚠
- p.Tyr183Cys Single submitter ⚠
- p.Tyr183Ser Single submitter ⚠
- p.Tyr54Cys Single submitter ⚠
- p.Tyr54Phe Single submitter ⚠
- p.Val77Met Single submitter ⚠