CAND1 — 73 ClinVar variants
All ClinVar germline CAND1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
73 Uncertain significance
Full CAND1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CAND1 p.Ala561Val Uncertain significance Single submitter
- CAND1 p.Arg777His Uncertain significance Single submitter
- CAND1 p.Asn599Ser Uncertain significance Single submitter
- CAND1 p.Asn736Ser Uncertain significance Single submitter
- CAND1 p.Asp1101Asn Uncertain significance Single submitter
- CAND1 p.Asp1101His Uncertain significance Single submitter
- CAND1 p.Asp675Val Uncertain significance Single submitter
- CAND1 p.Cys942Tyr Uncertain significance Single submitter
- CAND1 p.Glu1055Gly Uncertain significance Single submitter
- CAND1 p.Glu221Lys Uncertain significance Single submitter
- CAND1 p.Gly819Ser Uncertain significance Single submitter
- CAND1 p.Gly853Ala Uncertain significance Single submitter
- CAND1 p.Gly977Asp Uncertain significance Single submitter
- CAND1 p.His365Arg Uncertain significance Single submitter
- CAND1 p.His508Arg Uncertain significance Single submitter
- CAND1 p.Ile1041Thr Uncertain significance Single submitter
- CAND1 p.Ile134Met Uncertain significance Single submitter
- CAND1 p.Ile495Met Uncertain significance Single submitter
- CAND1 p.Ile690Val Uncertain significance Single submitter
- CAND1 p.Ile849Val Uncertain significance Single submitter
- CAND1 p.Leu967Phe Uncertain significance Single submitter
- CAND1 p.Lys812Glu Uncertain significance Single submitter
- CAND1 p.Met457Val Uncertain significance Single submitter
- CAND1 p.Phe658Tyr Uncertain significance Single submitter
- CAND1 p.Pro1187Ala Uncertain significance Single submitter
- CAND1 p.Pro424Arg Uncertain significance Single submitter
- CAND1 p.Pro609Ser Uncertain significance Single submitter
- CAND1 p.Pro889Ser Uncertain significance Single submitter
- CAND1 p.Pro893Leu Uncertain significance Single submitter
- CAND1 p.Ser1203Thr Uncertain significance Single submitter
- CAND1 p.Ser223Thr Uncertain significance Single submitter
- CAND1 p.Ser242Asn Uncertain significance Single submitter
- CAND1 p.Ser714Asn Uncertain significance Single submitter
- CAND1 p.Thr230Lys Uncertain significance Single submitter
- CAND1 p.Thr791Asn Uncertain significance Single submitter
- CAND1 p.Thr93Ala Uncertain significance Single submitter
- CAND1 p.Tyr564Ser Uncertain significance Single submitter
- CAND1 p.Tyr980Cys Uncertain significance Single submitter
- CAND1 p.Val148Ile Uncertain significance Single submitter
- CAND1 p.Val922Leu Uncertain significance Single submitter
-
CAND1 p.Gly246Asp
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 32
The independent predictors disagree with each other — read with care.
- CAND1 p.Ala1209Glu Uncertain significance Single submitter
- CAND1 p.Ala1209Val Uncertain significance Single submitter
- CAND1 p.Ala378Thr Uncertain significance Single submitter
- CAND1 p.Asn599Lys Uncertain significance Single submitter
- CAND1 p.Cys453Tyr Uncertain significance Single submitter
- CAND1 p.Cys454Gly Uncertain significance Single submitter
- CAND1 p.Gln511Arg Uncertain significance Single submitter
- CAND1 p.Gln897Arg Uncertain significance Single submitter
- CAND1 p.Glu650Lys Uncertain significance Single submitter
- CAND1 p.Gly605Val Uncertain significance Single submitter
- CAND1 p.Ile1102Thr Uncertain significance Single submitter
- CAND1 p.Ile298Met Uncertain significance Single submitter
- CAND1 p.Ile380Met Uncertain significance Single submitter
- CAND1 p.Ile713Thr Uncertain significance Single submitter
- CAND1 p.Leu476Phe Uncertain significance Single submitter
- CAND1 p.Lys262Thr Uncertain significance Single submitter
- CAND1 p.Pro187Ser Uncertain significance Single submitter
- CAND1 p.Pro292Ser Uncertain significance Single submitter
- CAND1 p.Pro531Thr Uncertain significance Single submitter
- CAND1 p.Pro653Arg Uncertain significance Single submitter
- CAND1 p.Pro782Thr Uncertain significance Single submitter
- CAND1 p.Pro889Leu Uncertain significance Single submitter
- CAND1 p.Ser833Thr Uncertain significance Single submitter
- CAND1 p.Thr296Ala Uncertain significance Single submitter
- CAND1 p.Thr32Met Uncertain significance Single submitter
- CAND1 p.Thr450Asn Uncertain significance Single submitter
- CAND1 p.Thr459Asn Uncertain significance Single submitter
- CAND1 p.Tyr372Phe Uncertain significance Single submitter
- CAND1 p.Val375Ile Uncertain significance Single submitter
- CAND1 p.Val503Ile Uncertain significance Single submitter
- CAND1 p.Val549Ile Uncertain significance Single submitter
- CAND1 p.Val885Met Uncertain significance Single submitter
All CAND1 variants
Uncertain significance 73
- p.Ala1209Glu Single submitter ⚠
- p.Ala1209Val Single submitter ⚠
- p.Ala378Thr Single submitter ⚠
- p.Ala561Val Single submitter ⚠
- p.Arg777His Single submitter ⚠
- p.Asn599Lys Single submitter ⚠
- p.Asn599Ser Single submitter ⚠
- p.Asn736Ser Single submitter ⚠
- p.Asp1101Asn Single submitter ⚠
- p.Asp1101His Single submitter ⚠
- p.Asp675Val Single submitter ⚠
- p.Cys453Tyr Single submitter ⚠
- p.Cys454Gly Single submitter ⚠
- p.Cys942Tyr Single submitter ⚠
- p.Gln511Arg Single submitter ⚠
- p.Gln897Arg Single submitter ⚠
- p.Glu1055Gly Single submitter ⚠
- p.Glu221Lys Single submitter ⚠
- p.Glu650Lys Single submitter ⚠
- p.Gly605Val Single submitter ⚠
- p.Gly819Ser Single submitter ⚠
- p.Gly853Ala Single submitter ⚠
- p.Gly977Asp Single submitter ⚠
- p.His365Arg Single submitter ⚠
- p.His508Arg Single submitter ⚠
- p.Ile1041Thr Single submitter ⚠
- p.Ile1102Thr Single submitter ⚠
- p.Ile134Met Single submitter ⚠
- p.Ile298Met Single submitter ⚠
- p.Ile380Met Single submitter ⚠
- p.Ile495Met Single submitter ⚠
- p.Ile690Val Single submitter ⚠
- p.Ile713Thr Single submitter ⚠
- p.Ile849Val Single submitter ⚠
- p.Leu476Phe Single submitter ⚠
- p.Leu967Phe Single submitter ⚠
- p.Lys262Thr Single submitter ⚠
- p.Lys812Glu Single submitter ⚠
- p.Met457Val Single submitter ⚠
- p.Phe658Tyr Single submitter ⚠
- p.Pro1187Ala Single submitter ⚠
- p.Pro187Ser Single submitter ⚠
- p.Pro292Ser Single submitter ⚠
- p.Pro424Arg Single submitter ⚠
- p.Pro531Thr Single submitter ⚠
- p.Pro609Ser Single submitter ⚠
- p.Pro653Arg Single submitter ⚠
- p.Pro782Thr Single submitter ⚠
- p.Pro889Leu Single submitter ⚠
- p.Pro889Ser Single submitter ⚠
- p.Pro893Leu Single submitter ⚠
- p.Ser1203Thr Single submitter ⚠
- p.Ser223Thr Single submitter ⚠
- p.Ser242Asn Single submitter ⚠
- p.Ser714Asn Single submitter ⚠
- p.Ser833Thr Single submitter ⚠
- p.Thr230Lys Single submitter ⚠
- p.Thr296Ala Single submitter ⚠
- p.Thr32Met Single submitter ⚠
- p.Thr450Asn Single submitter ⚠
- p.Thr459Asn Single submitter ⚠
- p.Thr791Asn Single submitter ⚠
- p.Thr93Ala Single submitter ⚠
- p.Tyr372Phe Single submitter ⚠
- p.Tyr564Ser Single submitter ⚠
- p.Tyr980Cys Single submitter ⚠
- p.Val148Ile Single submitter ⚠
- p.Val375Ile Single submitter ⚠
- p.Val503Ile Single submitter ⚠
- p.Val549Ile Single submitter ⚠
- p.Val885Met Single submitter ⚠
- p.Val922Leu Single submitter ⚠
- p.Gly246Asp No assertion criteria prostate cancer ⚠