CAND2 — 244 ClinVar variants

All ClinVar germline CAND2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 229 flagged for review →

5 Benign · 14 Likely benign · 225 Uncertain significance

Full CAND2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 229

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 111

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 118

The independent predictors disagree with each other — read with care.

All CAND2 variants

Benign 5

p.Arg1028Cys Multiple submitters
p.Arg987Gln Multiple submitters ⚠
p.His709Arg Multiple submitters
p.Ser491= Multiple submitters
p.Ala1136Val Single submitter ⚠

Likely benign 14

p.Ser999= Multiple submitters
p.Ala203= Single submitter
p.Ala215Thr Single submitter
p.Ala487= Single submitter
p.Ala680= Single submitter
p.Arg550Gln Single submitter
p.Asn704= Single submitter
p.Cys71= Single submitter
p.Cys945= Single submitter
p.Glu331Val Single submitter ⚠
p.Ser32Leu Single submitter ⚠
p.Thr509= Single submitter
p.Val450Ile Single submitter
p.Val543Leu Single submitter

Uncertain significance 225

p.Arg768Cys Multiple submitters ⚠
p.Ala1187Val Single submitter ⚠
p.Ala1215Thr Single submitter ⚠
p.Ala171Thr Single submitter ⚠
p.Ala195Val Single submitter ⚠
p.Ala254Ser Single submitter ⚠
p.Ala361Asp Single submitter ⚠
p.Ala416Val Single submitter ⚠
p.Ala440Thr Single submitter ⚠
p.Ala464Ser Single submitter ⚠
p.Ala472Thr Single submitter ⚠
p.Ala541Ser Single submitter ⚠
p.Ala630Thr Single submitter ⚠
p.Ala701Val Single submitter ⚠
p.Ala775Ser Single submitter ⚠
p.Ala783Val Single submitter ⚠
p.Ala810Val Single submitter ⚠
p.Ala884Val Single submitter ⚠
p.Ala890Thr Single submitter ⚠
p.Ala925Thr Single submitter ⚠
p.Ala948Thr Single submitter ⚠
p.Ala981Gly Single submitter ⚠
p.Arg1028Leu Single submitter ⚠
p.Arg1047Trp Single submitter ⚠
p.Arg1065Gln Single submitter ⚠
p.Arg1065Trp Single submitter ⚠
p.Arg1087Trp Single submitter ⚠
p.Arg1125Trp Single submitter ⚠
p.Arg1134Gln Single submitter ⚠
p.Arg1179Cys Single submitter ⚠
p.Arg1179His Single submitter ⚠
p.Arg192Cys Single submitter ⚠
p.Arg258His Single submitter ⚠
p.Arg352His Single submitter ⚠
p.Arg366Trp Single submitter ⚠
p.Arg383His Single submitter ⚠
p.Arg384Cys Single submitter ⚠
p.Arg405Trp Single submitter ⚠
p.Arg443Gln Single submitter ⚠
p.Arg443Trp Single submitter ⚠
p.Arg448Gly Single submitter ⚠
p.Arg448Trp Single submitter ⚠
p.Arg453Leu Single submitter ⚠
p.Arg489Cys Single submitter ⚠
p.Arg496Trp Single submitter ⚠
p.Arg557Gly Single submitter ⚠
p.Arg557Lys Single submitter ⚠
p.Arg559Gln Single submitter ⚠
p.Arg559Trp Single submitter ⚠
p.Arg577Gln Single submitter ⚠
p.Arg590Trp Single submitter ⚠
p.Arg605Gln Single submitter ⚠
p.Arg605Trp Single submitter ⚠
p.Arg622Gln Single submitter ⚠
p.Arg627Gln Single submitter ⚠
p.Arg627Trp Single submitter ⚠
p.Arg662Trp Single submitter ⚠
p.Arg669Gln Single submitter ⚠
p.Arg742Trp Single submitter ⚠
p.Arg768His Single submitter ⚠
p.Arg806Gln Single submitter ⚠
p.Arg806Trp Single submitter ⚠
p.Arg825His Single submitter ⚠
p.Arg887His Single submitter ⚠
p.Arg887Leu Single submitter ⚠
p.Arg944Leu Single submitter ⚠
p.Arg953Gln Single submitter ⚠
p.Arg953Trp Single submitter ⚠
p.Arg96Gln Single submitter ⚠
p.Arg96Trp Single submitter ⚠
p.Arg974Cys Single submitter ⚠
p.Arg974His Single submitter ⚠
p.Arg983Trp Single submitter ⚠
p.Asn299Thr Single submitter ⚠
p.Asp1051Asn Single submitter ⚠
p.Asp1066Tyr Single submitter ⚠
p.Asp1082Asn Single submitter ⚠
p.Asp1106Gly Single submitter ⚠
p.Asp1120Asn Single submitter ⚠
p.Asp1175Glu Single submitter ⚠
p.Asp209Asn Single submitter ⚠
p.Asp270His Single submitter ⚠
p.Asp311Asn Single submitter ⚠
p.Asp344Gly Single submitter ⚠
p.Asp346Asn Single submitter ⚠
p.Asp372Asn Single submitter ⚠
p.Asp372His Single submitter ⚠
p.Asp42Glu Single submitter ⚠
p.Asp829Asn Single submitter ⚠
p.Asp936Asn Single submitter ⚠
p.Asp98Asn Single submitter ⚠
p.Cys1158Ser Single submitter ⚠
p.Cys456Tyr Single submitter ⚠
p.Gln1001Arg Single submitter ⚠
p.Gln1059Glu Single submitter ⚠
p.Gln280Arg Single submitter ⚠
p.Gln681His Single submitter ⚠
p.Gln712His Single submitter ⚠
p.Gln859Arg Single submitter ⚠
p.Gln911Arg Single submitter ⚠
p.Glu100Ala Single submitter ⚠
p.Glu1152Lys Single submitter ⚠
p.Glu116Ala Single submitter ⚠
p.Glu1193Lys Single submitter ⚠
p.Glu264Lys Single submitter ⚠
p.Glu510Lys Single submitter ⚠
p.Glu540Lys Single submitter ⚠
p.Glu905Lys Single submitter ⚠
p.Glu920Asp Single submitter ⚠
p.Gly107Ser Single submitter ⚠
p.Gly1117Arg Single submitter ⚠
p.Gly1117Trp Single submitter ⚠
p.Gly432Glu Single submitter ⚠
p.Gly455Arg Single submitter ⚠
p.Gly465Asp Single submitter ⚠
p.Gly62Ser Single submitter ⚠
p.Gly759Ala Single submitter ⚠
p.Gly851Cys Single submitter ⚠
p.Gly889Ala Single submitter ⚠
p.Gly961Arg Single submitter ⚠
p.His1003Arg Single submitter ⚠
p.His1113Tyr Single submitter ⚠
p.His255Tyr Single submitter ⚠
p.His516Leu Single submitter ⚠
p.His518Asn Single submitter ⚠
p.Ile1013Ser Single submitter ⚠
p.Ile1013Thr Single submitter ⚠
p.Ile1151Thr Single submitter ⚠
p.Ile134Val Single submitter ⚠
p.Ile142Thr Single submitter ⚠
p.Ile359Val Single submitter ⚠
p.Ile537Met Single submitter ⚠
p.Leu102Pro Single submitter ⚠
p.Leu1032Pro Single submitter ⚠
p.Leu1067Ile Single submitter ⚠
p.Leu1098Pro Single submitter ⚠
p.Leu1105Pro Single submitter ⚠
p.Leu1127Val Single submitter ⚠
p.Leu252Val Single submitter ⚠
p.Leu34Ser Single submitter ⚠
p.Leu403Val Single submitter ⚠
p.Leu555Arg Single submitter ⚠
p.Leu578Arg Single submitter ⚠
p.Leu602Arg Single submitter ⚠
p.Leu650Gln Single submitter ⚠
p.Leu796Arg Single submitter ⚠
p.Leu796Gln Single submitter ⚠
p.Leu811Pro Single submitter ⚠
p.Leu862Pro Single submitter ⚠
p.Leu965Val Single submitter ⚠
p.Leu971Phe Single submitter ⚠
p.Lys111Asn Single submitter ⚠
p.Lys1168Met Single submitter ⚠
p.Lys70Arg Single submitter ⚠
p.Lys962Arg Single submitter ⚠
p.Met1073Val Single submitter ⚠
p.Met1094Leu Single submitter ⚠
p.Met1182Val Single submitter ⚠
p.Met1200Thr Single submitter ⚠
p.Phe1129Cys Single submitter ⚠
p.Phe1203Leu Single submitter ⚠
p.Phe22Leu Single submitter ⚠
p.Phe484Ile Single submitter ⚠
p.Phe660Ile Single submitter ⚠
p.Pro1043Leu Single submitter ⚠
p.Pro1055Ser Single submitter ⚠
p.Pro119Ala Single submitter ⚠
p.Pro168Leu Single submitter ⚠
p.Pro295Thr Single submitter ⚠
p.Pro371Ser Single submitter ⚠
p.Pro410Leu Single submitter ⚠
p.Pro520Arg Single submitter ⚠
p.Pro524Ser Single submitter ⚠
p.Pro554Leu Single submitter ⚠
p.Pro612Ser Single submitter ⚠
p.Pro689Ser Single submitter ⚠
p.Pro74Leu Single submitter ⚠
p.Pro833Leu Single submitter ⚠
p.Pro898Leu Single submitter ⚠
p.Ser1011Asn Single submitter ⚠
p.Ser1044Leu Single submitter ⚠
p.Ser1205Pro Single submitter ⚠
p.Ser1209Phe Single submitter ⚠
p.Ser1229Gly Single submitter ⚠
p.Ser185Arg Single submitter ⚠
p.Ser318Asn Single submitter ⚠
p.Ser364Thr Single submitter ⚠
p.Ser365Leu Single submitter ⚠
p.Ser449Arg Single submitter ⚠
p.Ser480Leu Single submitter ⚠
p.Ser490Cys Single submitter ⚠
p.Ser682Asn Single submitter ⚠
p.Ser746Leu Single submitter ⚠
p.Ser824Cys Single submitter ⚠
p.Ser882Leu Single submitter ⚠
p.Ser97Leu Single submitter ⚠
p.Thr1128Ala Single submitter ⚠
p.Thr1137Ser Single submitter ⚠
p.Thr122Ala Single submitter ⚠
p.Thr574Ile Single submitter ⚠
p.Thr613Met Single submitter ⚠
p.Thr626Ile Single submitter ⚠
p.Thr672Ile Single submitter ⚠
p.Thr722Ala Single submitter ⚠
p.Thr767Ala Single submitter ⚠
p.Thr86Ile Single submitter ⚠
p.Thr90Ile Single submitter ⚠
p.Tyr774Cys Single submitter ⚠
p.Val1086Met Single submitter ⚠
p.Val113Ile Single submitter ⚠
p.Val1185Ala Single submitter ⚠
p.Val244Gly Single submitter ⚠
p.Val351Ala Single submitter ⚠
p.Val351Leu Single submitter ⚠
p.Val380Leu Single submitter ⚠
p.Val380Met Single submitter ⚠
p.Val402Met Single submitter ⚠
p.Val434Met Single submitter ⚠
p.Val639Ile Single submitter ⚠
p.Val692Met Single submitter ⚠
p.Val695Met Single submitter ⚠
p.Val715Ala Single submitter ⚠
p.Val808Ala Single submitter ⚠
p.Val839Leu Single submitter ⚠
p.Val877Leu Single submitter ⚠