CAPG — 45 ClinVar variants
All ClinVar germline CAPG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
3 Benign · 4 Likely benign · 38 Uncertain significance
Full CAPG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CAPG p.Ala229Thr Uncertain significance Single submitter
- CAPG p.Ala81Pro Uncertain significance Single submitter
- CAPG p.Arg202Pro Uncertain significance Single submitter
- CAPG p.Arg299Gln Uncertain significance Single submitter
- CAPG p.Arg71Gln Uncertain significance Single submitter
- CAPG p.Arg96Cys Uncertain significance Single submitter
- CAPG p.Asn245His Uncertain significance Single submitter
- CAPG p.Asp281Gly Uncertain significance Single submitter
- CAPG p.Gly259Glu Uncertain significance Single submitter
- CAPG p.Leu84His Uncertain significance Single submitter
- CAPG p.Met261Lys Uncertain significance Single submitter
- CAPG p.Phe106Ser Uncertain significance Single submitter
- CAPG p.Phe110Leu Uncertain significance Single submitter
- CAPG p.Pro271Ser Uncertain significance Single submitter
- CAPG p.Trp347Gly Uncertain significance Single submitter
- CAPG p.Tyr140Cys Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CAPG p.Ala206Thr Uncertain significance Single submitter
- CAPG p.Ala241Gly Uncertain significance Single submitter
- CAPG p.Arg112Trp Uncertain significance Single submitter
- CAPG p.Arg149Cys Uncertain significance Single submitter
- CAPG p.Arg149Ser Uncertain significance Single submitter
- CAPG p.Arg153Trp Uncertain significance Single submitter
- CAPG p.Arg25Gln Uncertain significance Single submitter
- CAPG p.Arg319Cys Uncertain significance Single submitter
- CAPG p.Arg91Gln Uncertain significance Single submitter
- CAPG p.Arg96His Uncertain significance Single submitter
- CAPG p.Asp192Gly Uncertain significance Single submitter
- CAPG p.Glu97Gln Uncertain significance Single submitter
- CAPG p.Gly204Ser Uncertain significance Single submitter
- CAPG p.Leu155Gln Uncertain significance Single submitter
- CAPG p.Lys227Glu Uncertain significance Single submitter
- CAPG p.Met261Val Uncertain significance Single submitter
- CAPG p.Pro31Leu Uncertain significance Single submitter
- CAPG p.Pro324Arg Uncertain significance Single submitter
- CAPG p.Ser44Leu Uncertain significance Single submitter
- CAPG p.Val208Met Uncertain significance Single submitter
- CAPG p.Val34Met Uncertain significance Single submitter
- CAPG p.Val93Met Uncertain significance Single submitter
All CAPG variants
Benign 3
- p.Asn287= Single submitter
- p.Lys227Arg Single submitter
- p.Pro111fs Single submitter
Likely benign 4
- p.Arg112Gln Single submitter
- p.Gln36Arg Single submitter
- p.Lys243Arg Single submitter
- p.Ser8= Single submitter
Uncertain significance 38
- p.Ala206Thr Single submitter ⚠
- p.Ala229Thr Single submitter ⚠
- p.Ala241Gly Single submitter ⚠
- p.Ala81Pro Single submitter ⚠
- p.Arg112Trp Single submitter ⚠
- p.Arg149Cys Single submitter ⚠
- p.Arg149Ser Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Arg202Pro Single submitter ⚠
- p.Arg25Gln Single submitter ⚠
- p.Arg299Gln Single submitter ⚠
- p.Arg319Cys Single submitter ⚠
- p.Arg71Gln Single submitter ⚠
- p.Arg91Gln Single submitter ⚠
- p.Arg96Cys Single submitter ⚠
- p.Arg96His Single submitter ⚠
- p.Asn245His Single submitter ⚠
- p.Asp192Gly Single submitter ⚠
- p.Asp281Gly Single submitter ⚠
- p.Glu97Gln Single submitter ⚠
- p.Gly204Ser Single submitter ⚠
- p.Gly259Glu Single submitter ⚠
- p.Leu155Gln Single submitter ⚠
- p.Leu84His Single submitter ⚠
- p.Lys227Glu Single submitter ⚠
- p.Met261Lys Single submitter ⚠
- p.Met261Val Single submitter ⚠
- p.Phe106Ser Single submitter ⚠
- p.Phe110Leu Single submitter ⚠
- p.Pro271Ser Single submitter ⚠
- p.Pro31Leu Single submitter ⚠
- p.Pro324Arg Single submitter ⚠
- p.Ser44Leu Single submitter ⚠
- p.Trp347Gly Single submitter ⚠
- p.Tyr140Cys Single submitter ⚠
- p.Val208Met Single submitter ⚠
- p.Val34Met Single submitter ⚠
- p.Val93Met Single submitter ⚠