Sugi Variant

Sugi Variant/CAVIN4

CAVIN4 — 118 ClinVar variants

All ClinVar germline CAVIN4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →

2 Conflicting · 12 Benign · 1 Benign/Likely benign · 25 Likely benign · 78 Uncertain significance

Full CAVIN4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 70

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 56

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 12

The independent predictors disagree with each other — read with care.

All CAVIN4 variants

Conflicting classifications of pathogenicity 2

Benign 12

Benign/Likely benign 1

Likely benign 25

Uncertain significance 78