Sugi Variant

Sugi Variant/CBL

CBL — 2299 ClinVar variants

All ClinVar germline CBL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1196 flagged for review →

11 Pathogenic · 11 Pathogenic/Likely pathogenic · 14 Likely pathogenic · 118 Conflicting · 93 Benign · 32 Benign/Likely benign · 629 Likely benign · 1391 Uncertain significance

Full CBL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 1196

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 54

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 811

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 811

Predictors split 331

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 331

All CBL variants

Pathogenic 11

Pathogenic/Likely pathogenic 11

Likely pathogenic 14

Conflicting classifications of pathogenicity 118

Benign 93

Benign/Likely benign 32

Likely benign 629

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 1391

Showing the top 300 by review status; the full set is in the sitemap.