CCDC191 — 118 ClinVar variants
All ClinVar germline CCDC191 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
5 Likely benign · 113 Uncertain significance
Full CCDC191 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC191 p.Ala331Thr Uncertain significance Single submitter
- CCDC191 p.Ala415Thr Uncertain significance Single submitter
- CCDC191 p.Ala596Ser Uncertain significance Single submitter
- CCDC191 p.Ala800Asp Uncertain significance Single submitter
- CCDC191 p.Ala800Val Uncertain significance Single submitter
- CCDC191 p.Arg19Leu Uncertain significance Single submitter
- CCDC191 p.Arg25Thr Uncertain significance Single submitter
- CCDC191 p.Arg361Gly Uncertain significance Single submitter
- CCDC191 p.Arg368Thr Uncertain significance Single submitter
- CCDC191 p.Arg497Lys Uncertain significance Single submitter
- CCDC191 p.Arg538Thr Uncertain significance Single submitter
- CCDC191 p.Arg555Cys Uncertain significance Single submitter
- CCDC191 p.Arg645Gly Uncertain significance Single submitter
- CCDC191 p.Arg790His Uncertain significance Single submitter
- CCDC191 p.Asn387Lys Uncertain significance Single submitter
- CCDC191 p.Asp158Asn Uncertain significance Single submitter
- CCDC191 p.Asp855Asn Uncertain significance Single submitter
- CCDC191 p.Cys671Tyr Uncertain significance Single submitter
- CCDC191 p.Gln154Lys Uncertain significance Single submitter
- CCDC191 p.Gln619Arg Uncertain significance Single submitter
- CCDC191 p.Gln71His Uncertain significance Single submitter
- CCDC191 p.Gln804Leu Uncertain significance Single submitter
- CCDC191 p.Glu111Lys Uncertain significance Single submitter
- CCDC191 p.Glu149Gly Uncertain significance Single submitter
- CCDC191 p.Glu248Lys Uncertain significance Single submitter
- CCDC191 p.Glu279Lys Uncertain significance Single submitter
- CCDC191 p.Glu287Asp Uncertain significance Single submitter
- CCDC191 p.Glu301Gly Uncertain significance Single submitter
- CCDC191 p.Glu614Lys Uncertain significance Single submitter
- CCDC191 p.Glu742Gln Uncertain significance Single submitter
- CCDC191 p.Glu918Lys Uncertain significance Single submitter
- CCDC191 p.Glu936Lys Uncertain significance Single submitter
- CCDC191 p.His556Arg Uncertain significance Single submitter
- CCDC191 p.Ile260Met Uncertain significance Single submitter
- CCDC191 p.Ile81Thr Uncertain significance Single submitter
- CCDC191 p.Ile823Val Uncertain significance Single submitter
- CCDC191 p.Leu336Gln Uncertain significance Single submitter
- CCDC191 p.Leu3Pro Uncertain significance Single submitter
- CCDC191 p.Leu537Arg Uncertain significance Single submitter
- CCDC191 p.Leu810Pro Uncertain significance Single submitter
- CCDC191 p.Lys47Glu Uncertain significance Single submitter
- CCDC191 p.Lys681Gln Uncertain significance Single submitter
- CCDC191 p.Lys839Gln Uncertain significance Single submitter
- CCDC191 p.Lys884Gln Uncertain significance Single submitter
- CCDC191 p.Met15Val Uncertain significance Single submitter
- CCDC191 p.Met170Val Uncertain significance Single submitter
- CCDC191 p.Met171Val Uncertain significance Single submitter
- CCDC191 p.Met721Val Uncertain significance Single submitter
- CCDC191 p.Met784Val Uncertain significance Single submitter
- CCDC191 p.Phe788Ser Uncertain significance Single submitter
- CCDC191 p.Pro27Leu Uncertain significance Single submitter
- CCDC191 p.Pro29Ser Uncertain significance Single submitter
- CCDC191 p.Pro466Ser Uncertain significance Single submitter
- CCDC191 p.Pro477Ala Uncertain significance Single submitter
- CCDC191 p.Pro477Ser Uncertain significance Single submitter
- CCDC191 p.Pro515Ala Uncertain significance Single submitter
- CCDC191 p.Pro654Ser Uncertain significance Single submitter
- CCDC191 p.Pro68Ser Uncertain significance Single submitter
- CCDC191 p.Pro908Ser Uncertain significance Single submitter
- CCDC191 p.Ser492Asn Uncertain significance Single submitter
- CCDC191 p.Ser604Asn Uncertain significance Single submitter
- CCDC191 p.Ser67Asn Uncertain significance Single submitter
- CCDC191 p.Thr152Ala Uncertain significance Single submitter
- CCDC191 p.Thr266Ala Uncertain significance Single submitter
- CCDC191 p.Thr522Asn Uncertain significance Single submitter
- CCDC191 p.Thr875Ala Uncertain significance Single submitter
- CCDC191 p.Thr875Ser Uncertain significance Single submitter
- CCDC191 p.Trp757Arg Uncertain significance Single submitter
- CCDC191 p.Tyr920His Uncertain significance Single submitter
- CCDC191 p.Val119Gly Uncertain significance Single submitter
- CCDC191 p.Val119Leu Uncertain significance Single submitter
- CCDC191 p.Val153Ile Uncertain significance Single submitter
- CCDC191 p.Val231Glu Uncertain significance Single submitter
- CCDC191 p.Val852Met Uncertain significance Single submitter
- CCDC191 p.Val912Ile Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- CCDC191 p.Ala347Thr Uncertain significance Single submitter
- CCDC191 p.Ala669Val Uncertain significance Single submitter
- CCDC191 p.Arg203His Uncertain significance Single submitter
- CCDC191 p.Arg206Leu Uncertain significance Single submitter
- CCDC191 p.Arg265Cys Uncertain significance Single submitter
- CCDC191 p.Arg328Trp Uncertain significance Single submitter
- CCDC191 p.Arg398Trp Uncertain significance Single submitter
- CCDC191 p.Arg430Gly Uncertain significance Single submitter
- CCDC191 p.Arg673Trp Uncertain significance Single submitter
- CCDC191 p.Arg697His Uncertain significance Single submitter
- CCDC191 p.Arg713Gln Uncertain significance Single submitter
- CCDC191 p.Arg717Lys Uncertain significance Single submitter
- CCDC191 p.Arg759Gly Uncertain significance Single submitter
- CCDC191 p.Arg896Gln Uncertain significance Single submitter
- CCDC191 p.Asp187Glu Uncertain significance Single submitter
- CCDC191 p.Asp855Tyr Uncertain significance Single submitter
- CCDC191 p.Gln735His Uncertain significance Single submitter
- CCDC191 p.Glu233Gln Uncertain significance Single submitter
- CCDC191 p.Glu234Gly Uncertain significance Single submitter
- CCDC191 p.Glu234Val Uncertain significance Single submitter
- CCDC191 p.Glu259Gln Uncertain significance Single submitter
- CCDC191 p.Glu579Lys Uncertain significance Single submitter
- CCDC191 p.Glu670Gly Uncertain significance Single submitter
- CCDC191 p.Glu894Lys Uncertain significance Single submitter
- CCDC191 p.His774Tyr Uncertain significance Single submitter
- CCDC191 p.Ile577Val Uncertain significance Single submitter
- CCDC191 p.Leu484Phe Uncertain significance Single submitter
- CCDC191 p.Leu748Phe Uncertain significance Single submitter
- CCDC191 p.Leu907Ile Uncertain significance Single submitter
- CCDC191 p.Lys432Met Uncertain significance Single submitter
- CCDC191 p.Lys752Asn Uncertain significance Single submitter
- CCDC191 p.Lys887Thr Uncertain significance Single submitter
- CCDC191 p.Phe156Cys Uncertain significance Single submitter
- CCDC191 p.Pro656Leu Uncertain significance Single submitter
- CCDC191 p.Ser121Ile Uncertain significance Single submitter
- CCDC191 p.Ser150Arg Uncertain significance Single submitter
- CCDC191 p.Tyr366Cys Uncertain significance Single submitter
- CCDC191 p.Tyr806Asp Uncertain significance Single submitter
All CCDC191 variants
Likely benign 5
- p.Arg877Gln Single submitter
- p.Asn129Ser Single submitter
- p.Lys136Arg Single submitter
- p.Met784Leu Single submitter
- p.Tyr396His Single submitter
Uncertain significance 113
- p.Ala331Thr Single submitter ⚠
- p.Ala347Thr Single submitter ⚠
- p.Ala415Thr Single submitter ⚠
- p.Ala596Ser Single submitter ⚠
- p.Ala669Val Single submitter ⚠
- p.Ala800Asp Single submitter ⚠
- p.Ala800Val Single submitter ⚠
- p.Arg19Leu Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg206Leu Single submitter ⚠
- p.Arg25Thr Single submitter ⚠
- p.Arg265Cys Single submitter ⚠
- p.Arg328Trp Single submitter ⚠
- p.Arg361Gly Single submitter ⚠
- p.Arg368Thr Single submitter ⚠
- p.Arg398Trp Single submitter ⚠
- p.Arg430Gly Single submitter ⚠
- p.Arg497Lys Single submitter ⚠
- p.Arg538Thr Single submitter ⚠
- p.Arg555Cys Single submitter ⚠
- p.Arg645Gly Single submitter ⚠
- p.Arg673Trp Single submitter ⚠
- p.Arg697His Single submitter ⚠
- p.Arg713Gln Single submitter ⚠
- p.Arg717Lys Single submitter ⚠
- p.Arg759Gly Single submitter ⚠
- p.Arg790His Single submitter ⚠
- p.Arg896Gln Single submitter ⚠
- p.Asn387Lys Single submitter ⚠
- p.Asp158Asn Single submitter ⚠
- p.Asp187Glu Single submitter ⚠
- p.Asp855Asn Single submitter ⚠
- p.Asp855Tyr Single submitter ⚠
- p.Cys671Tyr Single submitter ⚠
- p.Gln154Lys Single submitter ⚠
- p.Gln619Arg Single submitter ⚠
- p.Gln71His Single submitter ⚠
- p.Gln735His Single submitter ⚠
- p.Gln804Leu Single submitter ⚠
- p.Glu111Lys Single submitter ⚠
- p.Glu149Gly Single submitter ⚠
- p.Glu233Gln Single submitter ⚠
- p.Glu234Gly Single submitter ⚠
- p.Glu234Val Single submitter ⚠
- p.Glu248Lys Single submitter ⚠
- p.Glu259Gln Single submitter ⚠
- p.Glu279Lys Single submitter ⚠
- p.Glu287Asp Single submitter ⚠
- p.Glu301Gly Single submitter ⚠
- p.Glu579Lys Single submitter ⚠
- p.Glu614Lys Single submitter ⚠
- p.Glu670Gly Single submitter ⚠
- p.Glu742Gln Single submitter ⚠
- p.Glu894Lys Single submitter ⚠
- p.Glu918Lys Single submitter ⚠
- p.Glu936Lys Single submitter ⚠
- p.His556Arg Single submitter ⚠
- p.His774Tyr Single submitter ⚠
- p.Ile260Met Single submitter ⚠
- p.Ile577Val Single submitter ⚠
- p.Ile81Thr Single submitter ⚠
- p.Ile823Val Single submitter ⚠
- p.Leu336Gln Single submitter ⚠
- p.Leu3Pro Single submitter ⚠
- p.Leu484Phe Single submitter ⚠
- p.Leu537Arg Single submitter ⚠
- p.Leu748Phe Single submitter ⚠
- p.Leu810Pro Single submitter ⚠
- p.Leu907Ile Single submitter ⚠
- p.Lys432Met Single submitter ⚠
- p.Lys47Glu Single submitter ⚠
- p.Lys681Gln Single submitter ⚠
- p.Lys752Asn Single submitter ⚠
- p.Lys839Gln Single submitter ⚠
- p.Lys884Gln Single submitter ⚠
- p.Lys887Thr Single submitter ⚠
- p.Met15Val Single submitter ⚠
- p.Met170Val Single submitter ⚠
- p.Met171Val Single submitter ⚠
- p.Met721Val Single submitter ⚠
- p.Met784Val Single submitter ⚠
- p.Phe156Cys Single submitter ⚠
- p.Phe788Ser Single submitter ⚠
- p.Pro27Leu Single submitter ⚠
- p.Pro29Ser Single submitter ⚠
- p.Pro466Ser Single submitter ⚠
- p.Pro477Ala Single submitter ⚠
- p.Pro477Ser Single submitter ⚠
- p.Pro515Ala Single submitter ⚠
- p.Pro654Ser Single submitter ⚠
- p.Pro656Leu Single submitter ⚠
- p.Pro68Ser Single submitter ⚠
- p.Pro908Ser Single submitter ⚠
- p.Ser121Ile Single submitter ⚠
- p.Ser150Arg Single submitter ⚠
- p.Ser492Asn Single submitter ⚠
- p.Ser604Asn Single submitter ⚠
- p.Ser67Asn Single submitter ⚠
- p.Thr152Ala Single submitter ⚠
- p.Thr266Ala Single submitter ⚠
- p.Thr522Asn Single submitter ⚠
- p.Thr875Ala Single submitter ⚠
- p.Thr875Ser Single submitter ⚠
- p.Trp757Arg Single submitter ⚠
- p.Tyr366Cys Single submitter ⚠
- p.Tyr806Asp Single submitter ⚠
- p.Tyr920His Single submitter ⚠
- p.Val119Gly Single submitter ⚠
- p.Val119Leu Single submitter ⚠
- p.Val153Ile Single submitter ⚠
- p.Val231Glu Single submitter ⚠
- p.Val852Met Single submitter ⚠
- p.Val912Ile Single submitter ⚠