CCDC93 — 90 ClinVar variants
All ClinVar germline CCDC93 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 88 flagged for review →
1 Benign · 1 Likely benign · 88 Uncertain significance
Full CCDC93 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 88
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC93 p.Ala226Val Uncertain significance Single submitter
- CCDC93 p.Ala262Thr Uncertain significance Single submitter
- CCDC93 p.Ala272Thr Uncertain significance Single submitter
- CCDC93 p.Ala370Thr Uncertain significance Single submitter
- CCDC93 p.Ala510Thr Uncertain significance Single submitter
- CCDC93 p.Arg126Gly Uncertain significance Single submitter
- CCDC93 p.Arg197Gln Uncertain significance Single submitter
- CCDC93 p.Arg269His Uncertain significance Single submitter
- CCDC93 p.Arg317Gln Uncertain significance Single submitter
- CCDC93 p.Arg408Gln Uncertain significance Single submitter
- CCDC93 p.Arg473Pro Uncertain significance Single submitter
- CCDC93 p.Arg483Cys Uncertain significance Single submitter
- CCDC93 p.Arg500Lys Uncertain significance Single submitter
- CCDC93 p.Arg506Cys Uncertain significance Single submitter
- CCDC93 p.Asn265Ser Uncertain significance Single submitter
- CCDC93 p.Asp155Glu Uncertain significance Single submitter
- CCDC93 p.Asp527Gly Uncertain significance Single submitter
- CCDC93 p.Asp557Glu Uncertain significance Single submitter
- CCDC93 p.Asp67Gly Uncertain significance Single submitter
- CCDC93 p.Gln10Pro Uncertain significance Single submitter
- CCDC93 p.Glu241Lys Uncertain significance Single submitter
- CCDC93 p.Glu244Gln Uncertain significance Single submitter
- CCDC93 p.Glu266Asp Uncertain significance Single submitter
- CCDC93 p.Glu375Gln Uncertain significance Single submitter
- CCDC93 p.Glu535Lys Uncertain significance Single submitter
- CCDC93 p.Gly230Glu Uncertain significance Single submitter
- CCDC93 p.Gly2Arg Uncertain significance Single submitter
- CCDC93 p.His315Gln Uncertain significance Single submitter
- CCDC93 p.Ile286Met Uncertain significance Single submitter
- CCDC93 p.Leu192Val Uncertain significance Single submitter
- CCDC93 p.Leu596Trp Uncertain significance Single submitter
- CCDC93 p.Lys625Asn Uncertain significance Single submitter
- CCDC93 p.Lys629Glu Uncertain significance Single submitter
- CCDC93 p.Lys83Thr Uncertain significance Single submitter
- CCDC93 p.Met263Val Uncertain significance Single submitter
- CCDC93 p.Pro118Thr Uncertain significance Single submitter
- CCDC93 p.Pro13Leu Uncertain significance Single submitter
- CCDC93 p.Pro439Leu Uncertain significance Single submitter
- CCDC93 p.Ser305Arg Uncertain significance Single submitter
- CCDC93 p.Thr433Ile Uncertain significance Single submitter
- CCDC93 p.Thr448Ile Uncertain significance Single submitter
- CCDC93 p.Tyr205Cys Uncertain significance Single submitter
- CCDC93 p.Tyr465Cys Uncertain significance Single submitter
- CCDC93 p.Val511Leu Uncertain significance Single submitter
Predictors split 44
The independent predictors disagree with each other — read with care.
- CCDC93 p.Ala628Val Uncertain significance Single submitter
- CCDC93 p.Arg139His Uncertain significance Single submitter
- CCDC93 p.Arg184His Uncertain significance Single submitter
- CCDC93 p.Arg316Cys Uncertain significance Single submitter
- CCDC93 p.Arg456Gln Uncertain significance Single submitter
- CCDC93 p.Arg456Trp Uncertain significance Single submitter
- CCDC93 p.Arg491Cys Uncertain significance Single submitter
- CCDC93 p.Arg491His Uncertain significance Single submitter
- CCDC93 p.Arg556Gln Uncertain significance Single submitter
- CCDC93 p.Arg556Trp Uncertain significance Single submitter
- CCDC93 p.Arg561His Uncertain significance Single submitter
- CCDC93 p.Arg617Cys Uncertain significance Single submitter
- CCDC93 p.Asp155Gly Uncertain significance Single submitter
- CCDC93 p.Asp171Val Uncertain significance Single submitter
- CCDC93 p.Asp526Gly Uncertain significance Single submitter
- CCDC93 p.Gln254Leu Uncertain significance Single submitter
- CCDC93 p.Glu174Lys Uncertain significance Single submitter
- CCDC93 p.Glu292Lys Uncertain significance Single submitter
- CCDC93 p.Glu462Lys Uncertain significance Single submitter
- CCDC93 p.His512Tyr Uncertain significance Single submitter
- CCDC93 p.Ile30Thr Uncertain significance Single submitter
- CCDC93 p.Leu281Pro Uncertain significance Single submitter
- CCDC93 p.Leu354Gln Uncertain significance Single submitter
- CCDC93 p.Leu364Met Uncertain significance Single submitter
- CCDC93 p.Leu469Ser Uncertain significance Single submitter
- CCDC93 p.Leu494Ile Uncertain significance Single submitter
- CCDC93 p.Lys131Glu Uncertain significance Single submitter
- CCDC93 p.Lys352Glu Uncertain significance Single submitter
- CCDC93 p.Lys484Glu Uncertain significance Single submitter
- CCDC93 p.Lys613Arg Uncertain significance Single submitter
- CCDC93 p.Ser298Pro Uncertain significance Single submitter
- CCDC93 p.Ser445Phe Uncertain significance Single submitter
- CCDC93 p.Ser78Ala Uncertain significance Single submitter
- CCDC93 p.Thr17Arg Uncertain significance Single submitter
- CCDC93 p.Thr261Ile Uncertain significance Single submitter
- CCDC93 p.Thr330Ile Uncertain significance Single submitter
- CCDC93 p.Thr353Met Uncertain significance Single submitter
- CCDC93 p.Thr79Met Uncertain significance Single submitter
- CCDC93 p.Tyr137Cys Uncertain significance Single submitter
- CCDC93 p.Tyr141Phe Uncertain significance Single submitter
- CCDC93 p.Tyr182His Uncertain significance Single submitter
- CCDC93 p.Val319Gly Uncertain significance Single submitter
- CCDC93 p.Val70Ile Uncertain significance Single submitter
-
CCDC93 p.Arg474Ile
Uncertain significance
No assertion criteria
CCDC93-related condition
All CCDC93 variants
Benign 1
- p.Pro228Leu Multiple submitters
Likely benign 1
- p.Thr17Ile No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 88
- p.Ala226Val Single submitter ⚠
- p.Ala262Thr Single submitter ⚠
- p.Ala272Thr Single submitter ⚠
- p.Ala370Thr Single submitter ⚠
- p.Ala510Thr Single submitter ⚠
- p.Ala628Val Single submitter ⚠
- p.Arg126Gly Single submitter ⚠
- p.Arg139His Single submitter ⚠
- p.Arg184His Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Arg269His Single submitter ⚠
- p.Arg316Cys Single submitter ⚠
- p.Arg317Gln Single submitter ⚠
- p.Arg408Gln Single submitter ⚠
- p.Arg456Gln Single submitter ⚠
- p.Arg456Trp Single submitter ⚠
- p.Arg473Pro Single submitter ⚠
- p.Arg483Cys Single submitter ⚠
- p.Arg491Cys Single submitter ⚠
- p.Arg491His Single submitter ⚠
- p.Arg500Lys Single submitter ⚠
- p.Arg506Cys Single submitter ⚠
- p.Arg556Gln Single submitter ⚠
- p.Arg556Trp Single submitter ⚠
- p.Arg561His Single submitter ⚠
- p.Arg617Cys Single submitter ⚠
- p.Asn265Ser Single submitter ⚠
- p.Asp155Glu Single submitter ⚠
- p.Asp155Gly Single submitter ⚠
- p.Asp171Val Single submitter ⚠
- p.Asp526Gly Single submitter ⚠
- p.Asp527Gly Single submitter ⚠
- p.Asp557Glu Single submitter ⚠
- p.Asp67Gly Single submitter ⚠
- p.Gln10Pro Single submitter ⚠
- p.Gln254Leu Single submitter ⚠
- p.Glu174Lys Single submitter ⚠
- p.Glu241Lys Single submitter ⚠
- p.Glu244Gln Single submitter ⚠
- p.Glu266Asp Single submitter ⚠
- p.Glu292Lys Single submitter ⚠
- p.Glu375Gln Single submitter ⚠
- p.Glu462Lys Single submitter ⚠
- p.Glu535Lys Single submitter ⚠
- p.Gly230Glu Single submitter ⚠
- p.Gly2Arg Single submitter ⚠
- p.His315Gln Single submitter ⚠
- p.His512Tyr Single submitter ⚠
- p.Ile286Met Single submitter ⚠
- p.Ile30Thr Single submitter ⚠
- p.Leu192Val Single submitter ⚠
- p.Leu281Pro Single submitter ⚠
- p.Leu354Gln Single submitter ⚠
- p.Leu364Met Single submitter ⚠
- p.Leu469Ser Single submitter ⚠
- p.Leu494Ile Single submitter ⚠
- p.Leu596Trp Single submitter ⚠
- p.Lys131Glu Single submitter ⚠
- p.Lys352Glu Single submitter ⚠
- p.Lys484Glu Single submitter ⚠
- p.Lys613Arg Single submitter ⚠
- p.Lys625Asn Single submitter ⚠
- p.Lys629Glu Single submitter ⚠
- p.Lys83Thr Single submitter ⚠
- p.Met263Val Single submitter ⚠
- p.Pro118Thr Single submitter ⚠
- p.Pro13Leu Single submitter ⚠
- p.Pro439Leu Single submitter ⚠
- p.Ser298Pro Single submitter ⚠
- p.Ser305Arg Single submitter ⚠
- p.Ser445Phe Single submitter ⚠
- p.Ser78Ala Single submitter ⚠
- p.Thr17Arg Single submitter ⚠
- p.Thr261Ile Single submitter ⚠
- p.Thr330Ile Single submitter ⚠
- p.Thr353Met Single submitter ⚠
- p.Thr433Ile Single submitter ⚠
- p.Thr448Ile Single submitter ⚠
- p.Thr79Met Single submitter ⚠
- p.Tyr137Cys Single submitter ⚠
- p.Tyr141Phe Single submitter ⚠
- p.Tyr182His Single submitter ⚠
- p.Tyr205Cys Single submitter ⚠
- p.Tyr465Cys Single submitter ⚠
- p.Val319Gly Single submitter ⚠
- p.Val511Leu Single submitter ⚠
- p.Val70Ile Single submitter ⚠
- p.Arg474Ile No assertion criteria CCDC93-related condition ⚠