CCL11 — 20 ClinVar variants
All ClinVar germline CCL11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
2 Benign · 1 Likely benign · 17 Uncertain significance
Full CCL11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL11 p.Ala16Val Uncertain significance Single submitter
- CCL11 p.Ala69Asp Uncertain significance Single submitter
- CCL11 p.Cys32Ser Uncertain significance Single submitter
- CCL11 p.Cys32Trp Uncertain significance Single submitter
- CCL11 p.Thr31Ala Uncertain significance Single submitter
- CCL11 p.Val28Leu Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CCL11 p.Lys86Thr Benign Multiple submitters
- CCL11 p.Ala23Val Uncertain significance Single submitter
- CCL11 p.Ala5Ser Uncertain significance Single submitter
- CCL11 p.Ala61Ser Uncertain significance Single submitter
- CCL11 p.Arg45Gln Uncertain significance Single submitter
- CCL11 p.Leu68Pro Uncertain significance Single submitter
- CCL11 p.Lys40Met Uncertain significance Single submitter
- CCL11 p.Lys78Thr Uncertain significance Single submitter
- CCL11 p.Lys91Thr Uncertain significance Single submitter
- CCL11 p.Pro19His Uncertain significance Single submitter
- CCL11 p.Pro42Thr Uncertain significance Single submitter
- CCL11 p.Pro76His Uncertain significance Single submitter
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CCL11 p.Ala23Thr
Benign
No assertion criteria
CCL11-related disorder
All CCL11 variants
Benign 2
- p.Lys86Thr Multiple submitters ⚠
- p.Ala23Thr No assertion criteria CCL11-related disorder ⚠
Likely benign 1
- p.Val28= No assertion criteria CCL11-related disorder
Uncertain significance 17
- p.Ala16Val Single submitter ⚠
- p.Ala23Val Single submitter ⚠
- p.Ala5Ser Single submitter ⚠
- p.Ala61Ser Single submitter ⚠
- p.Ala69Asp Single submitter ⚠
- p.Arg45Gln Single submitter ⚠
- p.Cys32Ser Single submitter ⚠
- p.Cys32Trp Single submitter ⚠
- p.Leu68Pro Single submitter ⚠
- p.Lys40Met Single submitter ⚠
- p.Lys78Thr Single submitter ⚠
- p.Lys91Thr Single submitter ⚠
- p.Pro19His Single submitter ⚠
- p.Pro42Thr Single submitter ⚠
- p.Pro76His Single submitter ⚠
- p.Thr31Ala Single submitter ⚠
- p.Val28Leu Single submitter ⚠