CCL15 — 13 ClinVar variants
All ClinVar germline CCL15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
1 Likely benign · 12 Uncertain significance
Full CCL15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL15 p.Cys77Ser Uncertain significance Single submitter
- CCL15 p.Ile113Thr Uncertain significance Single submitter
- CCL15 p.Ile113Val Uncertain significance Single submitter
- CCL15 p.Leu66Arg Uncertain significance Single submitter
- CCL15 p.Met33Thr Uncertain significance Single submitter
- CCL15 p.Ser34Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CCL15 p.Ala15Gly Uncertain significance Single submitter
- CCL15 p.Arg90Gln Likely benign Single submitter
- CCL15 p.Arg90Trp Uncertain significance Single submitter
- CCL15 p.Lys106Gln Uncertain significance Single submitter
- CCL15 p.Lys68Arg Uncertain significance Single submitter
- CCL15 p.Pro80Leu Uncertain significance Single submitter
- CCL15 p.Val5Met Uncertain significance Single submitter
All CCL15 variants
Likely benign 1
- p.Arg90Gln Single submitter ⚠
Uncertain significance 12
- p.Ala15Gly Single submitter ⚠
- p.Arg90Trp Single submitter ⚠
- p.Cys77Ser Single submitter ⚠
- p.Ile113Thr Single submitter ⚠
- p.Ile113Val Single submitter ⚠
- p.Leu66Arg Single submitter ⚠
- p.Lys106Gln Single submitter ⚠
- p.Lys68Arg Single submitter ⚠
- p.Met33Thr Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Ser34Leu Single submitter ⚠
- p.Val5Met Single submitter ⚠