CCL5 — 12 ClinVar variants
All ClinVar germline CCL5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
1 Pathogenic · 2 Likely benign · 9 Uncertain significance
Full CCL5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 5
The independent predictors disagree with each other — read with care.
All CCL5 variants
Pathogenic 1
- c.76+231T>C No assertion criteria Human immunodeficiency virus type 1, rapid disease progression with infection by
Uncertain significance 9
- p.Arg40His Single submitter ⚠
- p.Arg70His Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Cys33Arg Single submitter ⚠
- p.Lys68Arg Single submitter ⚠
- p.Ser28Leu Single submitter ⚠
- p.Ser58Phe Single submitter ⚠
- p.Thr30Ala Single submitter ⚠
- p.Val72Met Single submitter ⚠