CCNE2 — 37 ClinVar variants
All ClinVar germline CCNE2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
2 Likely benign · 35 Uncertain significance
Full CCNE2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNE2 p.Asp222Gly Uncertain significance Single submitter
- CCNE2 p.Asp258Gly Uncertain significance Single submitter
- CCNE2 p.Glu323Gln Uncertain significance Single submitter
- CCNE2 p.Glu323Val Uncertain significance Single submitter
- CCNE2 p.Gly402Arg Uncertain significance Single submitter
- CCNE2 p.His159Tyr Uncertain significance Single submitter
- CCNE2 p.His355Arg Uncertain significance Single submitter
- CCNE2 p.His355Tyr Uncertain significance Single submitter
- CCNE2 p.His76Pro Uncertain significance Single submitter
- CCNE2 p.Ile307Thr Uncertain significance Single submitter
- CCNE2 p.Ile71Val Uncertain significance Single submitter
- CCNE2 p.Leu145Val Uncertain significance Single submitter
- CCNE2 p.Leu263Arg Uncertain significance Single submitter
- CCNE2 p.Leu278Phe Uncertain significance Single submitter
- CCNE2 p.Leu95Ile Uncertain significance Single submitter
- CCNE2 p.Lys128Arg Uncertain significance Single submitter
- CCNE2 p.Lys261Glu Uncertain significance Single submitter
- CCNE2 p.Met351Lys Uncertain significance Single submitter
- CCNE2 p.Phe210Leu Uncertain significance Single submitter
- CCNE2 p.Phe331Leu Uncertain significance Single submitter
- CCNE2 p.Pro401Ser Uncertain significance Single submitter
- CCNE2 p.Ser320Thr Uncertain significance Single submitter
- CCNE2 p.Ser337Asn Uncertain significance Single submitter
- CCNE2 p.Thr271Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CCNE2 p.Ala204Gly Uncertain significance Single submitter
- CCNE2 p.Glu221Lys Uncertain significance Single submitter
- CCNE2 p.His303Tyr Uncertain significance Single submitter
- CCNE2 p.Leu102Phe Uncertain significance Single submitter
- CCNE2 p.Lys182Arg Uncertain significance Single submitter
- CCNE2 p.Lys232Thr Uncertain significance Single submitter
- CCNE2 p.Lys32Gln Uncertain significance Single submitter
- CCNE2 p.Ser21Phe Uncertain significance Single submitter
- CCNE2 p.Thr157Ile Uncertain significance Single submitter
- CCNE2 p.Thr19Met Uncertain significance Single submitter
- CCNE2 p.Thr345Ile Likely benign Single submitter
- CCNE2 p.Val310Gly Uncertain significance Single submitter
All CCNE2 variants
Likely benign 2
- p.Ile243Val Single submitter
- p.Thr345Ile Single submitter ⚠
Uncertain significance 35
- p.Ala204Gly Single submitter ⚠
- p.Asp222Gly Single submitter ⚠
- p.Asp258Gly Single submitter ⚠
- p.Glu221Lys Single submitter ⚠
- p.Glu323Gln Single submitter ⚠
- p.Glu323Val Single submitter ⚠
- p.Gly402Arg Single submitter ⚠
- p.His159Tyr Single submitter ⚠
- p.His303Tyr Single submitter ⚠
- p.His355Arg Single submitter ⚠
- p.His355Tyr Single submitter ⚠
- p.His76Pro Single submitter ⚠
- p.Ile307Thr Single submitter ⚠
- p.Ile71Val Single submitter ⚠
- p.Leu102Phe Single submitter ⚠
- p.Leu145Val Single submitter ⚠
- p.Leu263Arg Single submitter ⚠
- p.Leu278Phe Single submitter ⚠
- p.Leu95Ile Single submitter ⚠
- p.Lys128Arg Single submitter ⚠
- p.Lys182Arg Single submitter ⚠
- p.Lys232Thr Single submitter ⚠
- p.Lys261Glu Single submitter ⚠
- p.Lys32Gln Single submitter ⚠
- p.Met351Lys Single submitter ⚠
- p.Phe210Leu Single submitter ⚠
- p.Phe331Leu Single submitter ⚠
- p.Pro401Ser Single submitter ⚠
- p.Ser21Phe Single submitter ⚠
- p.Ser320Thr Single submitter ⚠
- p.Ser337Asn Single submitter ⚠
- p.Thr157Ile Single submitter ⚠
- p.Thr19Met Single submitter ⚠
- p.Thr271Ala Single submitter ⚠
- p.Val310Gly Single submitter ⚠