CCNI — 31 ClinVar variants
All ClinVar germline CCNI variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
31 Uncertain significance
Full CCNI gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNI p.Ala190Thr Uncertain significance Single submitter
- CCNI p.Arg32Gln Uncertain significance Single submitter
- CCNI p.Arg32Trp Uncertain significance Single submitter
- CCNI p.Asn39His Uncertain significance Single submitter
- CCNI p.Asn60Ser Uncertain significance Single submitter
- CCNI p.Gln193His Uncertain significance Single submitter
- CCNI p.Gln361Arg Uncertain significance Single submitter
- CCNI p.His187Asp Uncertain significance Single submitter
- CCNI p.His245Tyr Uncertain significance Single submitter
- CCNI p.His309Arg Uncertain significance Single submitter
- CCNI p.Ile133Leu Uncertain significance Single submitter
- CCNI p.Leu97Ile Uncertain significance Single submitter
- CCNI p.Lys28Thr Uncertain significance Single submitter
- CCNI p.Lys317Arg Uncertain significance Single submitter
- CCNI p.Met201Leu Uncertain significance Single submitter
- CCNI p.Met206Ile Uncertain significance Single submitter
- CCNI p.Met206Val Uncertain significance Single submitter
- CCNI p.Pro311Ser Uncertain significance Single submitter
- CCNI p.Ser168Asn Uncertain significance Single submitter
- CCNI p.Val300Ala Uncertain significance Single submitter
- CCNI p.Val374Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CCNI p.Arg240Gln Uncertain significance Single submitter
- CCNI p.Asn9Tyr Uncertain significance Single submitter
- CCNI p.Asp117Val Uncertain significance Single submitter
- CCNI p.Ile153Val Uncertain significance Single submitter
- CCNI p.Ile337Phe Uncertain significance Single submitter
- CCNI p.Leu68Val Uncertain significance Single submitter
- CCNI p.Lys317Asn Uncertain significance Single submitter
- CCNI p.Phe66Tyr Uncertain significance Single submitter
- CCNI p.Ser352Cys Uncertain significance Single submitter
- CCNI p.Val80Ile Uncertain significance Single submitter
All CCNI variants
Uncertain significance 31
- p.Ala190Thr Single submitter ⚠
- p.Arg240Gln Single submitter ⚠
- p.Arg32Gln Single submitter ⚠
- p.Arg32Trp Single submitter ⚠
- p.Asn39His Single submitter ⚠
- p.Asn60Ser Single submitter ⚠
- p.Asn9Tyr Single submitter ⚠
- p.Asp117Val Single submitter ⚠
- p.Gln193His Single submitter ⚠
- p.Gln361Arg Single submitter ⚠
- p.His187Asp Single submitter ⚠
- p.His245Tyr Single submitter ⚠
- p.His309Arg Single submitter ⚠
- p.Ile133Leu Single submitter ⚠
- p.Ile153Val Single submitter ⚠
- p.Ile337Phe Single submitter ⚠
- p.Leu68Val Single submitter ⚠
- p.Leu97Ile Single submitter ⚠
- p.Lys28Thr Single submitter ⚠
- p.Lys317Arg Single submitter ⚠
- p.Lys317Asn Single submitter ⚠
- p.Met201Leu Single submitter ⚠
- p.Met206Ile Single submitter ⚠
- p.Met206Val Single submitter ⚠
- p.Phe66Tyr Single submitter ⚠
- p.Pro311Ser Single submitter ⚠
- p.Ser168Asn Single submitter ⚠
- p.Ser352Cys Single submitter ⚠
- p.Val300Ala Single submitter ⚠
- p.Val374Ile Single submitter ⚠
- p.Val80Ile Single submitter ⚠