CCPG1 — 101 ClinVar variants
All ClinVar germline CCPG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
7 Likely benign · 94 Uncertain significance
Full CCPG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCPG1 p.Ala576Val Uncertain significance Single submitter
- CCPG1 p.Ala75Thr Uncertain significance Single submitter
- CCPG1 p.Arg193Gln Uncertain significance Single submitter
- CCPG1 p.Arg209His Uncertain significance Single submitter
- CCPG1 p.Arg243Cys Uncertain significance Single submitter
- CCPG1 p.Arg476Gly Uncertain significance Single submitter
- CCPG1 p.Arg731Lys Uncertain significance Single submitter
- CCPG1 p.Asn416Ser Uncertain significance Single submitter
- CCPG1 p.Asn710Lys Uncertain significance Single submitter
- CCPG1 p.Asn710Ser Uncertain significance Single submitter
- CCPG1 p.Asp274Glu Uncertain significance Single submitter
- CCPG1 p.Asp34Glu Uncertain significance Single submitter
- CCPG1 p.Asp465Gly Uncertain significance Single submitter
- CCPG1 p.Asp669Asn Uncertain significance Single submitter
- CCPG1 p.Cys42Tyr Uncertain significance Single submitter
- CCPG1 p.Gln120Arg Uncertain significance Single submitter
- CCPG1 p.Gln143Arg Uncertain significance Single submitter
- CCPG1 p.Gln156Glu Uncertain significance Single submitter
- CCPG1 p.Glu127Asp Uncertain significance Single submitter
- CCPG1 p.Glu199Lys Uncertain significance Single submitter
- CCPG1 p.Glu333Lys Uncertain significance Single submitter
- CCPG1 p.Glu557Ala Uncertain significance Single submitter
- CCPG1 p.Glu595Gly Uncertain significance Single submitter
- CCPG1 p.Glu595Lys Uncertain significance Single submitter
- CCPG1 p.Glu620Gln Uncertain significance Single submitter
- CCPG1 p.Glu715Lys Uncertain significance Single submitter
- CCPG1 p.Gly230Glu Uncertain significance Single submitter
- CCPG1 p.Gly405Cys Uncertain significance Single submitter
- CCPG1 p.Gly548Ser Uncertain significance Single submitter
- CCPG1 p.Gly553Ala Uncertain significance Single submitter
- CCPG1 p.Gly58Arg Uncertain significance Single submitter
- CCPG1 p.His623Tyr Uncertain significance Single submitter
- CCPG1 p.Ile24Thr Uncertain significance Single submitter
- CCPG1 p.Ile55Thr Uncertain significance Single submitter
- CCPG1 p.Ile83Thr Uncertain significance Single submitter
- CCPG1 p.Ile83Val Uncertain significance Single submitter
- CCPG1 p.Leu447Met Uncertain significance Single submitter
- CCPG1 p.Lys242Glu Uncertain significance Single submitter
- CCPG1 p.Lys319Arg Uncertain significance Single submitter
- CCPG1 p.Lys421Glu Uncertain significance Single submitter
- CCPG1 p.Lys683Arg Uncertain significance Single submitter
- CCPG1 p.Met136Leu Uncertain significance Single submitter
- CCPG1 p.Met258Val Uncertain significance Single submitter
- CCPG1 p.Met496Arg Uncertain significance Single submitter
- CCPG1 p.Met68Leu Uncertain significance Single submitter
- CCPG1 p.Met711Leu Uncertain significance Single submitter
- CCPG1 p.Phe272Ser Uncertain significance Single submitter
- CCPG1 p.Phe485Val Uncertain significance Single submitter
- CCPG1 p.Phe700Leu Uncertain significance Single submitter
- CCPG1 p.Phe738Ser Uncertain significance Single submitter
- CCPG1 p.Pro572Leu Uncertain significance Single submitter
- CCPG1 p.Pro586Arg Uncertain significance Single submitter
- CCPG1 p.Pro740Arg Uncertain significance Single submitter
- CCPG1 p.Ser613Gly Uncertain significance Single submitter
- CCPG1 p.Ser630Cys Uncertain significance Single submitter
- CCPG1 p.Thr145Ile Uncertain significance Single submitter
- CCPG1 p.Thr200Asn Uncertain significance Single submitter
- CCPG1 p.Thr587Ile Uncertain significance Single submitter
- CCPG1 p.Tyr574Phe Uncertain significance Single submitter
- CCPG1 p.Tyr96Cys Uncertain significance Single submitter
- CCPG1 p.Val122Asp Uncertain significance Single submitter
- CCPG1 p.Val647Met Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- CCPG1 p.Arg179His Uncertain significance Single submitter
- CCPG1 p.Arg193Trp Uncertain significance Single submitter
- CCPG1 p.Arg311Ile Uncertain significance Single submitter
- CCPG1 p.Arg397Ser Uncertain significance Single submitter
- CCPG1 p.Arg436Trp Uncertain significance Single submitter
- CCPG1 p.Arg444His Uncertain significance Single submitter
- CCPG1 p.Asn351Asp Uncertain significance Single submitter
- CCPG1 p.Asp274Gly Uncertain significance Single submitter
- CCPG1 p.Asp274Val Uncertain significance Single submitter
- CCPG1 p.Glu385Gln Uncertain significance Single submitter
- CCPG1 p.Glu433Gly Uncertain significance Single submitter
- CCPG1 p.Glu86Gly Uncertain significance Single submitter
- CCPG1 p.Glu92Lys Uncertain significance Single submitter
- CCPG1 p.Gly688Ser Uncertain significance Single submitter
- CCPG1 p.His506Leu Uncertain significance Single submitter
- CCPG1 p.Ile95Met Uncertain significance Single submitter
- CCPG1 p.Leu221Phe Uncertain significance Single submitter
- CCPG1 p.Leu278Ser Uncertain significance Single submitter
- CCPG1 p.Lys300Thr Uncertain significance Single submitter
- CCPG1 p.Lys319Glu Uncertain significance Single submitter
- CCPG1 p.Lys530Glu Uncertain significance Single submitter
- CCPG1 p.Phe146Ser Uncertain significance Single submitter
- CCPG1 p.Phe536Leu Uncertain significance Single submitter
- CCPG1 p.Pro112Arg Uncertain significance Single submitter
- CCPG1 p.Ser140Cys Uncertain significance Single submitter
- CCPG1 p.Thr301Met Uncertain significance Single submitter
- CCPG1 p.Thr394Met Likely benign Single submitter
All CCPG1 variants
Likely benign 7
- p.Ala39Thr Single submitter
- p.Asn169His Single submitter
- p.Gln694= Single submitter
- p.Glu433= Single submitter
- p.Ile227Val Single submitter
- p.Leu194Pro Single submitter
- p.Thr394Met Single submitter ⚠
Uncertain significance 94
- p.Ala576Val Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Arg179His Single submitter ⚠
- p.Arg193Gln Single submitter ⚠
- p.Arg193Trp Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg243Cys Single submitter ⚠
- p.Arg311Ile Single submitter ⚠
- p.Arg397Ser Single submitter ⚠
- p.Arg436Trp Single submitter ⚠
- p.Arg444His Single submitter ⚠
- p.Arg476Gly Single submitter ⚠
- p.Arg731Lys Single submitter ⚠
- p.Arg746Gln Single submitter
- p.Arg752Cys Single submitter
- p.Asn351Asp Single submitter ⚠
- p.Asn416Ser Single submitter ⚠
- p.Asn710Lys Single submitter ⚠
- p.Asn710Ser Single submitter ⚠
- p.Asp274Glu Single submitter ⚠
- p.Asp274Gly Single submitter ⚠
- p.Asp274Val Single submitter ⚠
- p.Asp34Glu Single submitter ⚠
- p.Asp465Gly Single submitter ⚠
- p.Asp669Asn Single submitter ⚠
- p.Cys42Tyr Single submitter ⚠
- p.Gln120Arg Single submitter ⚠
- p.Gln143Arg Single submitter ⚠
- p.Gln156Glu Single submitter ⚠
- p.Gln806Leu Single submitter
- p.Glu127Asp Single submitter ⚠
- p.Glu199Lys Single submitter ⚠
- p.Glu333Lys Single submitter ⚠
- p.Glu385Gln Single submitter ⚠
- p.Glu433Gly Single submitter ⚠
- p.Glu557Ala Single submitter ⚠
- p.Glu595Gly Single submitter ⚠
- p.Glu595Lys Single submitter ⚠
- p.Glu620Gln Single submitter ⚠
- p.Glu715Lys Single submitter ⚠
- p.Glu86Gly Single submitter ⚠
- p.Glu92Lys Single submitter ⚠
- p.Gly230Glu Single submitter ⚠
- p.Gly405Cys Single submitter ⚠
- p.Gly548Ser Single submitter ⚠
- p.Gly553Ala Single submitter ⚠
- p.Gly58Arg Single submitter ⚠
- p.Gly688Ser Single submitter ⚠
- p.Gly784Asp Single submitter
- p.Gly799Trp Single submitter
- p.His506Leu Single submitter ⚠
- p.His623Tyr Single submitter ⚠
- p.Ile24Thr Single submitter ⚠
- p.Ile55Thr Single submitter ⚠
- p.Ile83Thr Single submitter ⚠
- p.Ile83Val Single submitter ⚠
- p.Ile95Met Single submitter ⚠
- p.Leu221Phe Single submitter ⚠
- p.Leu278Ser Single submitter ⚠
- p.Leu447Met Single submitter ⚠
- p.Lys242Glu Single submitter ⚠
- p.Lys300Thr Single submitter ⚠
- p.Lys319Arg Single submitter ⚠
- p.Lys319Glu Single submitter ⚠
- p.Lys421Glu Single submitter ⚠
- p.Lys530Glu Single submitter ⚠
- p.Lys683Arg Single submitter ⚠
- p.Met136Leu Single submitter ⚠
- p.Met258Val Single submitter ⚠
- p.Met496Arg Single submitter ⚠
- p.Met68Leu Single submitter ⚠
- p.Met711Leu Single submitter ⚠
- p.Phe146Ser Single submitter ⚠
- p.Phe272Ser Single submitter ⚠
- p.Phe485Val Single submitter ⚠
- p.Phe536Leu Single submitter ⚠
- p.Phe700Leu Single submitter ⚠
- p.Phe738Ser Single submitter ⚠
- p.Pro112Arg Single submitter ⚠
- p.Pro572Leu Single submitter ⚠
- p.Pro586Arg Single submitter ⚠
- p.Pro740Arg Single submitter ⚠
- p.Pro802Ser Single submitter
- p.Ser140Cys Single submitter ⚠
- p.Ser613Gly Single submitter ⚠
- p.Ser630Cys Single submitter ⚠
- p.Thr145Ile Single submitter ⚠
- p.Thr200Asn Single submitter ⚠
- p.Thr301Met Single submitter ⚠
- p.Thr587Ile Single submitter ⚠
- p.Tyr574Phe Single submitter ⚠
- p.Tyr96Cys Single submitter ⚠
- p.Val122Asp Single submitter ⚠
- p.Val647Met Single submitter ⚠