CCR8 — 44 ClinVar variants
All ClinVar germline CCR8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
2 Likely benign · 42 Uncertain significance
Full CCR8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCR8 p.Ala175Val Uncertain significance Single submitter
- CCR8 p.Arg347Cys Uncertain significance Single submitter
- CCR8 p.Asn199Ser Uncertain significance Single submitter
- CCR8 p.Asp130Asn Uncertain significance Single submitter
- CCR8 p.Asp270Glu Uncertain significance Single submitter
- CCR8 p.Cys341Gly Uncertain significance Single submitter
- CCR8 p.Glu333Lys Uncertain significance Single submitter
- CCR8 p.His344Asn Uncertain significance Single submitter
- CCR8 p.Ile124Val Uncertain significance Single submitter
- CCR8 p.Ile219Thr Uncertain significance Single submitter
- CCR8 p.Leu241Val Uncertain significance Single submitter
- CCR8 p.Leu75Ser Uncertain significance Single submitter
- CCR8 p.Met121Leu Uncertain significance Single submitter
- CCR8 p.Met149Ile Uncertain significance Single submitter
- CCR8 p.Met163Ile Uncertain significance Single submitter
- CCR8 p.Met215Ile Uncertain significance Single submitter
- CCR8 p.Phe315Leu Uncertain significance Single submitter
- CCR8 p.Pro331Leu Uncertain significance Single submitter
- CCR8 p.Ser23Gly Uncertain significance Single submitter
- CCR8 p.Ser312Leu Uncertain significance Single submitter
- CCR8 p.Thr13Asn Uncertain significance Single submitter
- CCR8 p.Thr234Ser Uncertain significance Single submitter
- CCR8 p.Val351Leu Uncertain significance Single submitter
- CCR8 p.Val85Phe Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CCR8 p.Ile196Ser Uncertain significance Single submitter
- CCR8 p.Ile314Val Uncertain significance Single submitter
- CCR8 p.Ile322Met Uncertain significance Single submitter
- CCR8 p.Ile57Val Uncertain significance Single submitter
- CCR8 p.Leu263Phe Uncertain significance Single submitter
- CCR8 p.Leu74Phe Uncertain significance Single submitter
- CCR8 p.Leu82Met Uncertain significance Single submitter
- CCR8 p.Lys233Asn Uncertain significance Single submitter
- CCR8 p.Lys309Thr Uncertain significance Single submitter
- CCR8 p.Met127Ile Uncertain significance Single submitter
- CCR8 p.Phe250Ser Uncertain significance Single submitter
- CCR8 p.Ser262Tyr Uncertain significance Single submitter
- CCR8 p.Thr146Met Uncertain significance Single submitter
- CCR8 p.Thr191Ile Uncertain significance Single submitter
- CCR8 p.Tyr16Cys Uncertain significance Single submitter
- CCR8 p.Val157Leu Uncertain significance Single submitter
- CCR8 p.Val244Phe Uncertain significance Single submitter
- CCR8 p.Val257Ile Uncertain significance Single submitter
All CCR8 variants
Likely benign 2
- p.Pro331Ser Single submitter
- p.Thr152Ala Single submitter
Uncertain significance 42
- p.Ala175Val Single submitter ⚠
- p.Arg347Cys Single submitter ⚠
- p.Asn199Ser Single submitter ⚠
- p.Asp130Asn Single submitter ⚠
- p.Asp270Glu Single submitter ⚠
- p.Cys341Gly Single submitter ⚠
- p.Glu333Lys Single submitter ⚠
- p.His344Asn Single submitter ⚠
- p.Ile124Val Single submitter ⚠
- p.Ile196Ser Single submitter ⚠
- p.Ile219Thr Single submitter ⚠
- p.Ile314Val Single submitter ⚠
- p.Ile322Met Single submitter ⚠
- p.Ile57Val Single submitter ⚠
- p.Leu241Val Single submitter ⚠
- p.Leu263Phe Single submitter ⚠
- p.Leu74Phe Single submitter ⚠
- p.Leu75Ser Single submitter ⚠
- p.Leu82Met Single submitter ⚠
- p.Lys233Asn Single submitter ⚠
- p.Lys309Thr Single submitter ⚠
- p.Met121Leu Single submitter ⚠
- p.Met127Ile Single submitter ⚠
- p.Met149Ile Single submitter ⚠
- p.Met163Ile Single submitter ⚠
- p.Met215Ile Single submitter ⚠
- p.Phe250Ser Single submitter ⚠
- p.Phe315Leu Single submitter ⚠
- p.Pro331Leu Single submitter ⚠
- p.Ser23Gly Single submitter ⚠
- p.Ser262Tyr Single submitter ⚠
- p.Ser312Leu Single submitter ⚠
- p.Thr13Asn Single submitter ⚠
- p.Thr146Met Single submitter ⚠
- p.Thr191Ile Single submitter ⚠
- p.Thr234Ser Single submitter ⚠
- p.Tyr16Cys Single submitter ⚠
- p.Val157Leu Single submitter ⚠
- p.Val244Phe Single submitter ⚠
- p.Val257Ile Single submitter ⚠
- p.Val351Leu Single submitter ⚠
- p.Val85Phe Single submitter ⚠