CCT6B — 80 ClinVar variants
All ClinVar germline CCT6B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
1 Benign · 3 Likely benign · 76 Uncertain significance
Full CCT6B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCT6B p.Ala126Thr Uncertain significance Single submitter
- CCT6B p.Ala18Val Uncertain significance Single submitter
- CCT6B p.Ala262Pro Uncertain significance Single submitter
- CCT6B p.Ala2Val Uncertain significance Single submitter
- CCT6B p.Ala390Asp Uncertain significance Single submitter
- CCT6B p.Ala6Val Uncertain significance Single submitter
- CCT6B p.Arg217Cys Uncertain significance Single submitter
- CCT6B p.Arg314Cys Uncertain significance Single submitter
- CCT6B p.Arg319Gly Uncertain significance Single submitter
- CCT6B p.Arg392Ile Uncertain significance Single submitter
- CCT6B p.Arg434Cys Uncertain significance Single submitter
- CCT6B p.Asn293Tyr Uncertain significance Single submitter
- CCT6B p.Asn400Asp Uncertain significance Single submitter
- CCT6B p.Asn61Ser Uncertain significance Single submitter
- CCT6B p.Asp107Glu Uncertain significance Single submitter
- CCT6B p.Asp174Asn Uncertain significance Single submitter
- CCT6B p.Asp213Gly Uncertain significance Single submitter
- CCT6B p.Asp491Gly Uncertain significance Single submitter
- CCT6B p.Cys343Phe Uncertain significance Single submitter
- CCT6B p.Glu263Lys Uncertain significance Single submitter
- CCT6B p.Glu352Ala Uncertain significance Single submitter
- CCT6B p.Gly100Arg Uncertain significance Single submitter
- CCT6B p.Gly113Arg Uncertain significance Single submitter
- CCT6B p.Gly329Asp Uncertain significance Single submitter
- CCT6B p.Gly39Ser Uncertain significance Single submitter
- CCT6B p.Gly410Glu Uncertain significance Single submitter
- CCT6B p.Gly525Arg Uncertain significance Single submitter
- CCT6B p.His115Tyr Uncertain significance Single submitter
- CCT6B p.His346Arg Uncertain significance Single submitter
- CCT6B p.Ile186Thr Uncertain significance Single submitter
- CCT6B p.Ile292Thr Uncertain significance Single submitter
- CCT6B p.Ile414Thr Uncertain significance Single submitter
- CCT6B p.Ile4Val Uncertain significance Single submitter
- CCT6B p.Ile515Val Uncertain significance Single submitter
- CCT6B p.Ile77Met Uncertain significance Single submitter
- CCT6B p.Leu210Phe Uncertain significance Single submitter
- CCT6B p.Leu445Phe Uncertain significance Single submitter
- CCT6B p.Leu63Arg Uncertain significance Single submitter
- CCT6B p.Lys10Arg Uncertain significance Single submitter
- CCT6B p.Lys261Arg Uncertain significance Single submitter
- CCT6B p.Lys426Arg Uncertain significance Single submitter
- CCT6B p.Lys45Glu Uncertain significance Single submitter
- CCT6B p.Met196Leu Uncertain significance Single submitter
- CCT6B p.Met407Thr Uncertain significance Single submitter
- CCT6B p.Met67Val Uncertain significance Single submitter
- CCT6B p.Pro448Leu Uncertain significance Single submitter
- CCT6B p.Ser49Phe Uncertain significance Single submitter
- CCT6B p.Ser9Pro Uncertain significance Single submitter
- CCT6B p.Thr202Ala Uncertain significance Single submitter
- CCT6B p.Thr354Ala Uncertain significance Single submitter
- CCT6B p.Thr354Ile Uncertain significance Single submitter
- CCT6B p.Thr36Ser Uncertain significance Single submitter
- CCT6B p.Thr88Arg Uncertain significance Single submitter
- CCT6B p.Thr93Ile Uncertain significance Single submitter
- CCT6B p.Val333Met Uncertain significance Single submitter
- CCT6B p.Val423Ile Uncertain significance Single submitter
- CCT6B p.Val450Phe Uncertain significance Single submitter
- CCT6B p.Val488Ile Uncertain significance Single submitter
- CCT6B p.Val488Leu Uncertain significance Single submitter
- CCT6B p.Val518Ala Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CCT6B p.Ala16Val Uncertain significance Single submitter
- CCT6B p.Arg35Gln Uncertain significance Single submitter
- CCT6B p.Asn234Ser Uncertain significance Single submitter
- CCT6B p.Asn8Ser Uncertain significance Single submitter
- CCT6B p.Asp166Val Uncertain significance Single submitter
- CCT6B p.Asp269Tyr Uncertain significance Single submitter
- CCT6B p.Gln386Lys Uncertain significance Single submitter
- CCT6B p.Gln68Pro Uncertain significance Single submitter
- CCT6B p.Glu132Ala Uncertain significance Single submitter
- CCT6B p.Gly525Ala Uncertain significance Single submitter
- CCT6B p.Leu339Ile Uncertain significance Single submitter
- CCT6B p.Ser9Cys Uncertain significance Single submitter
- CCT6B p.Val225Ala Uncertain significance Single submitter
All CCT6B variants
Benign 1
- c.615-2A>G Multiple submitters
Likely benign 3
- p.Ala468Thr Single submitter
- p.Ile398Val Single submitter
- p.Leu212= Single submitter
Uncertain significance 76
- p.Ala126Thr Single submitter ⚠
- p.Ala16Val Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala262Pro Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala390Asp Single submitter ⚠
- p.Ala433Asp Single submitter
- p.Ala6Val Single submitter ⚠
- p.Arg217Cys Single submitter ⚠
- p.Arg314Cys Single submitter ⚠
- p.Arg319Gly Single submitter ⚠
- p.Arg35Gln Single submitter ⚠
- p.Arg392Ile Single submitter ⚠
- p.Arg434Cys Single submitter ⚠
- p.Asn234Ser Single submitter ⚠
- p.Asn293Tyr Single submitter ⚠
- p.Asn400Asp Single submitter ⚠
- p.Asn61Ser Single submitter ⚠
- p.Asn8Ser Single submitter ⚠
- p.Asp107Glu Single submitter ⚠
- p.Asp166Val Single submitter ⚠
- p.Asp174Asn Single submitter ⚠
- p.Asp213Gly Single submitter ⚠
- p.Asp269Tyr Single submitter ⚠
- p.Asp491Gly Single submitter ⚠
- p.Asp85Asn Single submitter
- p.Cys343Phe Single submitter ⚠
- p.Gln386Lys Single submitter ⚠
- p.Gln68Pro Single submitter ⚠
- p.Glu132Ala Single submitter ⚠
- p.Glu263Lys Single submitter ⚠
- p.Glu352Ala Single submitter ⚠
- p.Gly100Arg Single submitter ⚠
- p.Gly113Arg Single submitter ⚠
- p.Gly329Asp Single submitter ⚠
- p.Gly39Ser Single submitter ⚠
- p.Gly410Glu Single submitter ⚠
- p.Gly525Ala Single submitter ⚠
- p.Gly525Arg Single submitter ⚠
- p.His115Tyr Single submitter ⚠
- p.His346Arg Single submitter ⚠
- p.Ile186Thr Single submitter ⚠
- p.Ile292Thr Single submitter ⚠
- p.Ile414Thr Single submitter ⚠
- p.Ile4Val Single submitter ⚠
- p.Ile515Val Single submitter ⚠
- p.Ile77Met Single submitter ⚠
- p.Leu210Phe Single submitter ⚠
- p.Leu339Ile Single submitter ⚠
- p.Leu445Phe Single submitter ⚠
- p.Leu63Arg Single submitter ⚠
- p.Lys10Arg Single submitter ⚠
- p.Lys261Arg Single submitter ⚠
- p.Lys426Arg Single submitter ⚠
- p.Lys45Glu Single submitter ⚠
- p.Met196Leu Single submitter ⚠
- p.Met407Thr Single submitter ⚠
- p.Met67Val Single submitter ⚠
- p.Pro448Leu Single submitter ⚠
- p.Ser49Phe Single submitter ⚠
- p.Ser9Cys Single submitter ⚠
- p.Ser9Pro Single submitter ⚠
- p.Thr202Ala Single submitter ⚠
- p.Thr354Ala Single submitter ⚠
- p.Thr354Ile Single submitter ⚠
- p.Thr36Ser Single submitter ⚠
- p.Thr88Arg Single submitter ⚠
- p.Thr93Ile Single submitter ⚠
- p.Val225Ala Single submitter ⚠
- p.Val333Met Single submitter ⚠
- p.Val423Ile Single submitter ⚠
- p.Val450Phe Single submitter ⚠
- p.Val488Ile Single submitter ⚠
- p.Val488Leu Single submitter ⚠
- p.Val510Ala Single submitter
- p.Val518Ala Single submitter ⚠