CD14 — 54 ClinVar variants
All ClinVar germline CD14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
2 Benign · 4 Likely benign · 48 Uncertain significance
Full CD14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD14 p.Ala114Thr Uncertain significance Single submitter
- CD14 p.Ala143Gly Uncertain significance Single submitter
- CD14 p.Ala184Thr Uncertain significance Single submitter
- CD14 p.Ala269Thr Uncertain significance Single submitter
- CD14 p.Ala98Ser Uncertain significance Single submitter
- CD14 p.Arg117Ser Uncertain significance Single submitter
- CD14 p.Arg158Cys Uncertain significance Single submitter
- CD14 p.Arg191Gly Uncertain significance Single submitter
- CD14 p.Arg308Lys Uncertain significance Single submitter
- CD14 p.Arg354Gly Uncertain significance Single submitter
- CD14 p.Arg354Ser Uncertain significance Single submitter
- CD14 p.Cys187Ser Uncertain significance Single submitter
- CD14 p.Glu235Lys Uncertain significance Single submitter
- CD14 p.Gly233Arg Uncertain significance Single submitter
- CD14 p.Gly328Arg Uncertain significance Single submitter
- CD14 p.Gly347Arg Uncertain significance Single submitter
- CD14 p.His16Gln Uncertain significance Single submitter
- CD14 p.His340Asn Uncertain significance Single submitter
- CD14 p.His340Tyr Uncertain significance Single submitter
- CD14 p.Leu161Phe Uncertain significance Single submitter
- CD14 p.Leu261Arg Uncertain significance Single submitter
- CD14 p.Leu89Phe Uncertain significance Single submitter
- CD14 p.Lys127Asn Uncertain significance Single submitter
- CD14 p.Phe69Cys Uncertain significance Single submitter
- CD14 p.Ser276Gly Uncertain significance Single submitter
- CD14 p.Val152Glu Uncertain significance Single submitter
- CD14 p.Val174Leu Uncertain significance Single submitter
- CD14 p.Val190Phe Uncertain significance Single submitter
- CD14 p.Val333Ile Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CD14 p.Ala75Gly Uncertain significance Single submitter
- CD14 p.Arg111His Uncertain significance Single submitter
- CD14 p.Asn204Ser Uncertain significance Single submitter
- CD14 p.Asn307Lys Uncertain significance Single submitter
- CD14 p.Asp74Ala Uncertain significance Single submitter
- CD14 p.Asp74Gly Uncertain significance Single submitter
- CD14 p.Leu123Phe Uncertain significance Single submitter
- CD14 p.Leu172Phe Uncertain significance Single submitter
- CD14 p.Pro222Leu Uncertain significance Single submitter
- CD14 p.Pro251Arg Uncertain significance Single submitter
- CD14 p.Pro267Leu Uncertain significance Single submitter
- CD14 p.Pro296Ala Uncertain significance Single submitter
- CD14 p.Pro41Leu Uncertain significance Single submitter
- CD14 p.Pro41Thr Uncertain significance Single submitter
- CD14 p.Ser145Tyr Uncertain significance Single submitter
- CD14 p.Thr197Asn Uncertain significance Single submitter
- CD14 p.Val152Leu Uncertain significance Single submitter
- CD14 p.Val265Ile Uncertain significance Single submitter
- CD14 p.Val359Met Uncertain significance Single submitter
All CD14 variants
Benign 2
- p.Met234Ile Single submitter
- p.Ser146= Single submitter
Likely benign 4
- p.Gly342Asp Single submitter
- p.His340Gln Single submitter
- p.Ser146Thr Single submitter
- p.Glu341Lys No assertion criteria CD14-related disorder
Uncertain significance 48
- p.Ala114Thr Single submitter ⚠
- p.Ala143Gly Single submitter ⚠
- p.Ala184Thr Single submitter ⚠
- p.Ala269Thr Single submitter ⚠
- p.Ala75Gly Single submitter ⚠
- p.Ala98Ser Single submitter ⚠
- p.Arg111His Single submitter ⚠
- p.Arg117Ser Single submitter ⚠
- p.Arg158Cys Single submitter ⚠
- p.Arg191Gly Single submitter ⚠
- p.Arg308Lys Single submitter ⚠
- p.Arg354Gly Single submitter ⚠
- p.Arg354Ser Single submitter ⚠
- p.Asn204Ser Single submitter ⚠
- p.Asn307Lys Single submitter ⚠
- p.Asp74Ala Single submitter ⚠
- p.Asp74Gly Single submitter ⚠
- p.Cys187Ser Single submitter ⚠
- p.Glu235Lys Single submitter ⚠
- p.Gly233Arg Single submitter ⚠
- p.Gly328Arg Single submitter ⚠
- p.Gly347Arg Single submitter ⚠
- p.His16Gln Single submitter ⚠
- p.His340Asn Single submitter ⚠
- p.His340Tyr Single submitter ⚠
- p.Leu123Phe Single submitter ⚠
- p.Leu161Phe Single submitter ⚠
- p.Leu172Phe Single submitter ⚠
- p.Leu261Arg Single submitter ⚠
- p.Leu89Phe Single submitter ⚠
- p.Lys127Asn Single submitter ⚠
- p.Phe69Cys Single submitter ⚠
- p.Pro222Leu Single submitter ⚠
- p.Pro251Arg Single submitter ⚠
- p.Pro267Leu Single submitter ⚠
- p.Pro296Ala Single submitter ⚠
- p.Pro41Leu Single submitter ⚠
- p.Pro41Thr Single submitter ⚠
- p.Ser145Tyr Single submitter ⚠
- p.Ser276Gly Single submitter ⚠
- p.Thr197Asn Single submitter ⚠
- p.Val152Glu Single submitter ⚠
- p.Val152Leu Single submitter ⚠
- p.Val174Leu Single submitter ⚠
- p.Val190Phe Single submitter ⚠
- p.Val265Ile Single submitter ⚠
- p.Val333Ile Single submitter ⚠
- p.Val359Met Single submitter ⚠