CD180 — 95 ClinVar variants
All ClinVar germline CD180 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →
4 Benign · 5 Likely benign · 86 Uncertain significance
Full CD180 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 87
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD180 p.Ala415Ser Uncertain significance Single submitter
- CD180 p.Ala466Ser Uncertain significance Single submitter
- CD180 p.Ala649Thr Uncertain significance Single submitter
- CD180 p.Arg75Thr Uncertain significance Single submitter
- CD180 p.Asn240Ser Uncertain significance Single submitter
- CD180 p.Asn380Lys Uncertain significance Single submitter
- CD180 p.Asn406Ile Uncertain significance Single submitter
- CD180 p.Cys18Tyr Uncertain significance Single submitter
- CD180 p.Cys28Tyr Uncertain significance Single submitter
- CD180 p.Cys506Arg Uncertain significance Single submitter
- CD180 p.Cys583Tyr Uncertain significance Single submitter
- CD180 p.Gln482Pro Uncertain significance Single submitter
- CD180 p.Gln98Arg Uncertain significance Single submitter
- CD180 p.Glu277Lys Uncertain significance Single submitter
- CD180 p.Glu367Gln Uncertain significance Single submitter
- CD180 p.Glu604Asp Uncertain significance Single submitter
- CD180 p.Gly231Glu Uncertain significance Single submitter
- CD180 p.Gly241Ser Uncertain significance Single submitter
- CD180 p.Gly364Ser Uncertain significance Single submitter
- CD180 p.Gly601Ala Uncertain significance Single submitter
- CD180 p.Gly626Glu Uncertain significance Single submitter
- CD180 p.His360Arg Uncertain significance Single submitter
- CD180 p.His463Gln Uncertain significance Single submitter
- CD180 p.His597Arg Uncertain significance Single submitter
- CD180 p.Ile143Asn Uncertain significance Single submitter
- CD180 p.Ile143Phe Uncertain significance Single submitter
- CD180 p.Ile161Ser Uncertain significance Single submitter
- CD180 p.Ile185Thr Uncertain significance Single submitter
- CD180 p.Ile630Thr Uncertain significance Single submitter
- CD180 p.Leu392Pro Uncertain significance Single submitter
- CD180 p.Leu424Val Uncertain significance Single submitter
- CD180 p.Lys125Arg Uncertain significance Single submitter
- CD180 p.Lys325Thr Uncertain significance Single submitter
- CD180 p.Lys488Asn Uncertain significance Single submitter
- CD180 p.Met267Thr Uncertain significance Single submitter
- CD180 p.Ser104Ile Uncertain significance Single submitter
- CD180 p.Ser236Thr Uncertain significance Single submitter
- CD180 p.Ser413Asn Uncertain significance Single submitter
- CD180 p.Ser74Asn Uncertain significance Single submitter
- CD180 p.Val356Met Uncertain significance Single submitter
- CD180 p.Val5Ile Uncertain significance Single submitter
Predictors split 46
The independent predictors disagree with each other — read with care.
- CD180 p.Thr430Ala Benign Multiple submitters
- CD180 p.Arg173Trp Uncertain significance Single submitter
- CD180 p.Arg472Trp Uncertain significance Single submitter
- CD180 p.Asn371Ser Uncertain significance Single submitter
- CD180 p.Asn451Ser Uncertain significance Single submitter
- CD180 p.Asn595Asp Uncertain significance Single submitter
- CD180 p.Asp262His Uncertain significance Single submitter
- CD180 p.Cys18Arg Uncertain significance Single submitter
- CD180 p.Gln102Glu Uncertain significance Single submitter
- CD180 p.Gly253Arg Uncertain significance Single submitter
- CD180 p.Gly312Trp Uncertain significance Single submitter
- CD180 p.Gly484Arg Uncertain significance Single submitter
- CD180 p.Gly545Val Uncertain significance Single submitter
- CD180 p.Gly601Val Uncertain significance Single submitter
- CD180 p.His349Gln Uncertain significance Single submitter
- CD180 p.Ile188Val Uncertain significance Single submitter
- CD180 p.Ile258Asn Uncertain significance Single submitter
- CD180 p.Ile486Thr Uncertain significance Single submitter
- CD180 p.Ile555Leu Uncertain significance Single submitter
- CD180 p.Leu250Phe Uncertain significance Single submitter
- CD180 p.Leu271Pro Uncertain significance Single submitter
- CD180 p.Leu375Val Uncertain significance Single submitter
- CD180 p.Leu540Arg Uncertain significance Single submitter
- CD180 p.Leu76Phe Uncertain significance Single submitter
- CD180 p.Lys176Gln Uncertain significance Single submitter
- CD180 p.Met116Thr Uncertain significance Single submitter
- CD180 p.Met116Val Uncertain significance Single submitter
- CD180 p.Phe180Leu Uncertain significance Single submitter
- CD180 p.Pro420Arg Uncertain significance Single submitter
- CD180 p.Pro420Leu Uncertain significance Single submitter
- CD180 p.Pro52Leu Uncertain significance Single submitter
- CD180 p.Pro52Thr Uncertain significance Single submitter
- CD180 p.Pro578Ser Uncertain significance Single submitter
- CD180 p.Ser153Arg Uncertain significance Single submitter
- CD180 p.Ser346Pro Uncertain significance Single submitter
- CD180 p.Ser612Phe Uncertain significance Single submitter
- CD180 p.Thr105Ile Uncertain significance Single submitter
- CD180 p.Thr135Ala Uncertain significance Single submitter
- CD180 p.Thr135Met Uncertain significance Single submitter
- CD180 p.Thr246Ala Uncertain significance Single submitter
- CD180 p.Thr306Pro Uncertain significance Single submitter
- CD180 p.Thr308Ile Uncertain significance Single submitter
- CD180 p.Thr348Ile Uncertain significance Single submitter
- CD180 p.Thr590Ile Uncertain significance Single submitter
- CD180 p.Thr80Ala Uncertain significance Single submitter
- CD180 p.Val525Ala Uncertain significance Single submitter
All CD180 variants
Benign 4
- p.Leu398= Multiple submitters
- p.Ser584= Multiple submitters
- p.Thr222= Multiple submitters
- p.Thr430Ala Multiple submitters ⚠
Likely benign 5
- p.Asp535Asn Single submitter
- p.Gly17Ser Single submitter
- p.Gly370Glu Single submitter
- p.Leu227= Single submitter
- p.Ser602= Single submitter
Uncertain significance 86
- p.Ala415Ser Single submitter ⚠
- p.Ala466Ser Single submitter ⚠
- p.Ala649Thr Single submitter ⚠
- p.Arg173Trp Single submitter ⚠
- p.Arg472Trp Single submitter ⚠
- p.Arg75Thr Single submitter ⚠
- p.Asn240Ser Single submitter ⚠
- p.Asn371Ser Single submitter ⚠
- p.Asn380Lys Single submitter ⚠
- p.Asn406Ile Single submitter ⚠
- p.Asn451Ser Single submitter ⚠
- p.Asn595Asp Single submitter ⚠
- p.Asp262His Single submitter ⚠
- p.Cys18Arg Single submitter ⚠
- p.Cys18Tyr Single submitter ⚠
- p.Cys28Tyr Single submitter ⚠
- p.Cys506Arg Single submitter ⚠
- p.Cys583Tyr Single submitter ⚠
- p.Gln102Glu Single submitter ⚠
- p.Gln482Pro Single submitter ⚠
- p.Gln98Arg Single submitter ⚠
- p.Glu277Lys Single submitter ⚠
- p.Glu367Gln Single submitter ⚠
- p.Glu604Asp Single submitter ⚠
- p.Gly231Glu Single submitter ⚠
- p.Gly241Ser Single submitter ⚠
- p.Gly253Arg Single submitter ⚠
- p.Gly312Trp Single submitter ⚠
- p.Gly364Ser Single submitter ⚠
- p.Gly484Arg Single submitter ⚠
- p.Gly545Val Single submitter ⚠
- p.Gly601Ala Single submitter ⚠
- p.Gly601Val Single submitter ⚠
- p.Gly626Glu Single submitter ⚠
- p.His349Gln Single submitter ⚠
- p.His360Arg Single submitter ⚠
- p.His463Gln Single submitter ⚠
- p.His597Arg Single submitter ⚠
- p.Ile143Asn Single submitter ⚠
- p.Ile143Phe Single submitter ⚠
- p.Ile161Ser Single submitter ⚠
- p.Ile185Thr Single submitter ⚠
- p.Ile188Val Single submitter ⚠
- p.Ile258Asn Single submitter ⚠
- p.Ile486Thr Single submitter ⚠
- p.Ile555Leu Single submitter ⚠
- p.Ile630Thr Single submitter ⚠
- p.Leu250Phe Single submitter ⚠
- p.Leu271Pro Single submitter ⚠
- p.Leu375Val Single submitter ⚠
- p.Leu392Pro Single submitter ⚠
- p.Leu424Val Single submitter ⚠
- p.Leu540Arg Single submitter ⚠
- p.Leu76Phe Single submitter ⚠
- p.Lys125Arg Single submitter ⚠
- p.Lys176Gln Single submitter ⚠
- p.Lys325Thr Single submitter ⚠
- p.Lys488Asn Single submitter ⚠
- p.Met116Thr Single submitter ⚠
- p.Met116Val Single submitter ⚠
- p.Met267Thr Single submitter ⚠
- p.Phe180Leu Single submitter ⚠
- p.Pro420Arg Single submitter ⚠
- p.Pro420Leu Single submitter ⚠
- p.Pro52Leu Single submitter ⚠
- p.Pro52Thr Single submitter ⚠
- p.Pro578Ser Single submitter ⚠
- p.Ser104Ile Single submitter ⚠
- p.Ser153Arg Single submitter ⚠
- p.Ser236Thr Single submitter ⚠
- p.Ser346Pro Single submitter ⚠
- p.Ser413Asn Single submitter ⚠
- p.Ser612Phe Single submitter ⚠
- p.Ser74Asn Single submitter ⚠
- p.Thr105Ile Single submitter ⚠
- p.Thr135Ala Single submitter ⚠
- p.Thr135Met Single submitter ⚠
- p.Thr246Ala Single submitter ⚠
- p.Thr306Pro Single submitter ⚠
- p.Thr308Ile Single submitter ⚠
- p.Thr348Ile Single submitter ⚠
- p.Thr590Ile Single submitter ⚠
- p.Thr80Ala Single submitter ⚠
- p.Val356Met Single submitter ⚠
- p.Val525Ala Single submitter ⚠
- p.Val5Ile Single submitter ⚠