CD209 — 46 ClinVar variants
All ClinVar germline CD209 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
5 Benign · 9 Likely benign · 32 Uncertain significance
Full CD209 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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CD209 p.Gln189Leu
Uncertain significance
Multiple submitters
dengue virus, susceptibility to
- CD209 p.Asp75Gly Uncertain significance Single submitter
- CD209 p.Cys284Ser Uncertain significance Single submitter
- CD209 p.Gln189Lys Uncertain significance Single submitter
- CD209 p.Gln212Leu Uncertain significance Single submitter
- CD209 p.Gly13Val Uncertain significance Single submitter
- CD209 p.Gly30Arg Uncertain significance Single submitter
- CD209 p.Gly41Cys Uncertain significance Single submitter
- CD209 p.His278Gln Uncertain significance Single submitter
- CD209 p.Ile281Thr Uncertain significance Single submitter
- CD209 p.Leu20Pro Uncertain significance Single submitter
- CD209 p.Leu56Val Uncertain significance Single submitter
- CD209 p.Pro399Arg Uncertain significance Single submitter
- CD209 p.Ser33Gly Uncertain significance Single submitter
- CD209 p.Val58Phe Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
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CD209 p.Glu214Asp
Uncertain significance
Multiple submitters
Mycobacterium tuberculosis, susceptibility to
- CD209 p.Ala132Ser Uncertain significance Single submitter
- CD209 p.Ala202Val Uncertain significance Single submitter
- CD209 p.Gln244Glu Uncertain significance Single submitter
- CD209 p.Gln71His Uncertain significance Single submitter
- CD209 p.Gln98His Uncertain significance Single submitter
- CD209 p.Glu18Lys Uncertain significance Single submitter
- CD209 p.Glu214Gly Uncertain significance Single submitter
- CD209 p.Glu353Lys Uncertain significance Single submitter
- CD209 p.Leu229Phe Uncertain significance Single submitter
- CD209 p.Leu34Ile Uncertain significance Single submitter
- CD209 p.Lys379Glu Uncertain significance Single submitter
- CD209 p.Phe269Leu Uncertain significance Single submitter
- CD209 p.Pro184Leu Uncertain significance Single submitter
- CD209 p.Ser141Tyr Uncertain significance Single submitter
- CD209 p.Ser72Cys Uncertain significance Single submitter
- CD209 p.Thr128Asn Uncertain significance Single submitter
All CD209 variants
Benign 5
- p.Ala357= Multiple submitters
- p.Ala395= Multiple submitters
- p.Asp331= Multiple submitters
- p.Arg221Gln No assertion criteria CD209-related disorder
- p.Arg309= No assertion criteria CD209-related disorder
Likely benign 9
- p.Ala381= Single submitter
- p.Arg129Gln Single submitter
- p.Arg198Gln Single submitter
- p.Gln244Arg Single submitter
- p.Ile294= Single submitter
- p.Lys200= Single submitter
- p.Lys223= Single submitter
- p.Ser310Ile Single submitter
- p.Thr174= Single submitter
Uncertain significance 32
- p.Gln189Leu Multiple submitters dengue virus, susceptibility to ⚠
- p.Glu214Asp Multiple submitters Mycobacterium tuberculosis, susceptibility to ⚠
- p.Ala132Ser Single submitter ⚠
- p.Ala202Val Single submitter ⚠
- p.Asp75Gly Single submitter ⚠
- p.Cys284Ser Single submitter ⚠
- p.Gln189Lys Single submitter ⚠
- p.Gln212Leu Single submitter ⚠
- p.Gln244Glu Single submitter ⚠
- p.Gln71His Single submitter ⚠
- p.Gln98His Single submitter ⚠
- p.Glu18Lys Single submitter ⚠
- p.Glu214Gly Single submitter ⚠
- p.Glu353Lys Single submitter ⚠
- p.Gly13Val Single submitter ⚠
- p.Gly30Arg Single submitter ⚠
- p.Gly41Cys Single submitter ⚠
- p.His278Gln Single submitter ⚠
- p.Ile281Thr Single submitter ⚠
- p.Leu20Pro Single submitter ⚠
- p.Leu229Phe Single submitter ⚠
- p.Leu34Ile Single submitter ⚠
- p.Leu56Val Single submitter ⚠
- p.Lys379Glu Single submitter ⚠
- p.Phe269Leu Single submitter ⚠
- p.Pro184Leu Single submitter ⚠
- p.Pro399Arg Single submitter ⚠
- p.Ser141Tyr Single submitter ⚠
- p.Ser33Gly Single submitter ⚠
- p.Ser72Cys Single submitter ⚠
- p.Thr128Asn Single submitter ⚠
- p.Val58Phe Single submitter ⚠