CD276 — 106 ClinVar variants
All ClinVar germline CD276 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 102 flagged for review →
2 Benign · 4 Likely benign · 100 Uncertain significance
Full CD276 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 102
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD276 p.Ala466Thr Uncertain significance Single submitter
- CD276 p.Ala516Gly Uncertain significance Single submitter
- CD276 p.Arg267Cys Uncertain significance Single submitter
- CD276 p.Arg301Gln Uncertain significance Single submitter
- CD276 p.Arg310Cys Uncertain significance Single submitter
- CD276 p.Asp524Asn Uncertain significance Single submitter
- CD276 p.Cys122Trp Uncertain significance Single submitter
- CD276 p.Cys165Tyr Uncertain significance Single submitter
- CD276 p.Glu335Asp Uncertain significance Single submitter
- CD276 p.Glu465Asp Uncertain significance Single submitter
- CD276 p.Glu497Gln Uncertain significance Single submitter
- CD276 p.Glu497Lys Uncertain significance Single submitter
- CD276 p.Glu527Asp Uncertain significance Single submitter
- CD276 p.Gly170Asp Uncertain significance Single submitter
- CD276 p.Gly336Ser Uncertain significance Single submitter
- CD276 p.Gly451Ala Uncertain significance Single submitter
- CD276 p.Gly451Asp Uncertain significance Single submitter
- CD276 p.Gly510Arg Uncertain significance Single submitter
- CD276 p.Leu100Arg Uncertain significance Single submitter
- CD276 p.Leu136Pro Uncertain significance Single submitter
- CD276 p.Pro239Ser Uncertain significance Single submitter
- CD276 p.Pro464Gln Uncertain significance Single submitter
- CD276 p.Pro464Leu Uncertain significance Single submitter
- CD276 p.Thr311Met Uncertain significance Single submitter
- CD276 p.Thr470Ala Uncertain significance Single submitter
- CD276 p.Tyr89Cys Uncertain significance Single submitter
- CD276 p.Val112Met Uncertain significance Single submitter
- CD276 p.Val330Met Uncertain significance Single submitter
- CD276 p.Val342Met Uncertain significance Single submitter
- CD276 p.Val425Ile Uncertain significance Single submitter
Predictors split 72
The independent predictors disagree with each other — read with care.
- CD276 p.Ala132Ser Uncertain significance Single submitter
- CD276 p.Ala139Ser Uncertain significance Single submitter
- CD276 p.Ala28Ser Uncertain significance Single submitter
- CD276 p.Ala312Thr Uncertain significance Single submitter
- CD276 p.Ala350Thr Uncertain significance Single submitter
- CD276 p.Ala351Val Uncertain significance Single submitter
- CD276 p.Ala432Gly Uncertain significance Single submitter
- CD276 p.Ala449Val Uncertain significance Single submitter
- CD276 p.Arg111His Uncertain significance Single submitter
- CD276 p.Arg113Gly Uncertain significance Single submitter
- CD276 p.Arg127Gln Uncertain significance Single submitter
- CD276 p.Arg127Trp Uncertain significance Single submitter
- CD276 p.Arg223Cys Uncertain significance Single submitter
- CD276 p.Arg223His Uncertain significance Single submitter
- CD276 p.Arg329Cys Uncertain significance Single submitter
- CD276 p.Arg329His Uncertain significance Single submitter
- CD276 p.Arg331His Uncertain significance Single submitter
- CD276 p.Arg345Trp Uncertain significance Single submitter
- CD276 p.Arg374Gln Uncertain significance Single submitter
- CD276 p.Arg374Trp Uncertain significance Single submitter
- CD276 p.Arg5Trp Uncertain significance Single submitter
- CD276 p.Asn282Lys Uncertain significance Single submitter
- CD276 p.Asn433Ile Uncertain significance Single submitter
- CD276 p.Asp128Asn Uncertain significance Single submitter
- CD276 p.Asp230Glu Uncertain significance Single submitter
- CD276 p.Gln182Lys Uncertain significance Single submitter
- CD276 p.Gln182Pro Uncertain significance Single submitter
- CD276 p.Gln447Lys Uncertain significance Single submitter
- CD276 p.Gln85Arg Uncertain significance Single submitter
- CD276 p.Glu117Lys Uncertain significance Single submitter
- CD276 p.Glu198Gly Uncertain significance Single submitter
- CD276 p.Glu273Lys Uncertain significance Single submitter
- CD276 p.Gly181Val Uncertain significance Single submitter
- CD276 p.Gly200Ser Uncertain significance Single submitter
- CD276 p.Gly57Asp Uncertain significance Single submitter
- CD276 p.Ile66Val Uncertain significance Single submitter
- CD276 p.Leu281Val Uncertain significance Single submitter
- CD276 p.Leu293Arg Uncertain significance Single submitter
- CD276 p.Leu439Gln Uncertain significance Single submitter
- CD276 p.Leu63Val Uncertain significance Single submitter
- CD276 p.Leu75Arg Uncertain significance Single submitter
- CD276 p.Lys153Arg Uncertain significance Single submitter
- CD276 p.Met195Thr Uncertain significance Single submitter
- CD276 p.Met365Leu Uncertain significance Single submitter
- CD276 p.Phe395Leu Likely benign Single submitter
- CD276 p.Phe462Leu Uncertain significance Single submitter
- CD276 p.Pro34Ser Uncertain significance Single submitter
- CD276 p.Pro443Arg Uncertain significance Single submitter
- CD276 p.Pro54Leu Uncertain significance Single submitter
- CD276 p.Pro56Ser Uncertain significance Single submitter
- CD276 p.Pro97Ser Uncertain significance Single submitter
- CD276 p.Ser166Phe Uncertain significance Single submitter
- CD276 p.Ser219Gly Uncertain significance Single submitter
- CD276 p.Ser271Phe Uncertain significance Single submitter
- CD276 p.Ser361Leu Uncertain significance Single submitter
- CD276 p.Ser385Ile Uncertain significance Single submitter
- CD276 p.Ser411Leu Uncertain significance Single submitter
- CD276 p.Ser452Pro Uncertain significance Single submitter
- CD276 p.Ser51Phe Uncertain significance Single submitter
- CD276 p.Thr93Met Uncertain significance Single submitter
- CD276 p.Val124Met Uncertain significance Single submitter
- CD276 p.Val134Ala Uncertain significance Single submitter
- CD276 p.Val134Ile Uncertain significance Single submitter
- CD276 p.Val226Ala Uncertain significance Single submitter
- CD276 p.Val226Met Uncertain significance Single submitter
- CD276 p.Val256Met Uncertain significance Single submitter
- CD276 p.Val31Ile Uncertain significance Single submitter
- CD276 p.Val352Ile Uncertain significance Single submitter
- CD276 p.Val440Leu Uncertain significance Single submitter
- CD276 p.Val469Met Uncertain significance Single submitter
- CD276 p.Val471Met Uncertain significance Single submitter
-
CD276 p.Arg113His
Likely benign
No assertion criteria
long QT syndrome
All CD276 variants
Benign 2
- p.Leu419= Multiple submitters
- c.734-7C>T Single submitter
Likely benign 4
- c.734-10C>T Single submitter
- p.Cys49Arg Single submitter
- p.Phe395Leu Single submitter ⚠
- p.Arg113His No assertion criteria long QT syndrome ⚠
Uncertain significance 100
- p.Ala132Ser Single submitter ⚠
- p.Ala139Ser Single submitter ⚠
- p.Ala28Ser Single submitter ⚠
- p.Ala312Thr Single submitter ⚠
- p.Ala350Thr Single submitter ⚠
- p.Ala351Val Single submitter ⚠
- p.Ala432Gly Single submitter ⚠
- p.Ala449Val Single submitter ⚠
- p.Ala466Thr Single submitter ⚠
- p.Ala516Gly Single submitter ⚠
- p.Arg111His Single submitter ⚠
- p.Arg113Gly Single submitter ⚠
- p.Arg127Gln Single submitter ⚠
- p.Arg127Trp Single submitter ⚠
- p.Arg223Cys Single submitter ⚠
- p.Arg223His Single submitter ⚠
- p.Arg267Cys Single submitter ⚠
- p.Arg301Gln Single submitter ⚠
- p.Arg310Cys Single submitter ⚠
- p.Arg329Cys Single submitter ⚠
- p.Arg329His Single submitter ⚠
- p.Arg331His Single submitter ⚠
- p.Arg345Trp Single submitter ⚠
- p.Arg374Gln Single submitter ⚠
- p.Arg374Trp Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Asn282Lys Single submitter ⚠
- p.Asn433Ile Single submitter ⚠
- p.Asp128Asn Single submitter ⚠
- p.Asp230Glu Single submitter ⚠
- p.Asp524Asn Single submitter ⚠
- p.Cys122Trp Single submitter ⚠
- p.Cys165Tyr Single submitter ⚠
- p.Gln182Lys Single submitter ⚠
- p.Gln182Pro Single submitter ⚠
- p.Gln447Lys Single submitter ⚠
- p.Gln85Arg Single submitter ⚠
- p.Glu117Lys Single submitter ⚠
- p.Glu198Gly Single submitter ⚠
- p.Glu273Lys Single submitter ⚠
- p.Glu335Asp Single submitter ⚠
- p.Glu465Asp Single submitter ⚠
- p.Glu497Gln Single submitter ⚠
- p.Glu497Lys Single submitter ⚠
- p.Glu527Asp Single submitter ⚠
- p.Gly170Asp Single submitter ⚠
- p.Gly181Val Single submitter ⚠
- p.Gly200Ser Single submitter ⚠
- p.Gly336Ser Single submitter ⚠
- p.Gly451Ala Single submitter ⚠
- p.Gly451Asp Single submitter ⚠
- p.Gly510Arg Single submitter ⚠
- p.Gly57Asp Single submitter ⚠
- p.Ile66Val Single submitter ⚠
- p.Leu100Arg Single submitter ⚠
- p.Leu136Pro Single submitter ⚠
- p.Leu281Val Single submitter ⚠
- p.Leu293Arg Single submitter ⚠
- p.Leu439Gln Single submitter ⚠
- p.Leu63Val Single submitter ⚠
- p.Leu75Arg Single submitter ⚠
- p.Lys153Arg Single submitter ⚠
- p.Met195Thr Single submitter ⚠
- p.Met365Leu Single submitter ⚠
- p.Phe462Leu Single submitter ⚠
- p.Pro239Ser Single submitter ⚠
- p.Pro34Ser Single submitter ⚠
- p.Pro443Arg Single submitter ⚠
- p.Pro464Gln Single submitter ⚠
- p.Pro464Leu Single submitter ⚠
- p.Pro54Leu Single submitter ⚠
- p.Pro56Ser Single submitter ⚠
- p.Pro97Ser Single submitter ⚠
- p.Ser166Phe Single submitter ⚠
- p.Ser219Gly Single submitter ⚠
- p.Ser271Phe Single submitter ⚠
- p.Ser361Leu Single submitter ⚠
- p.Ser385Ile Single submitter ⚠
- p.Ser411Leu Single submitter ⚠
- p.Ser452Pro Single submitter ⚠
- p.Ser51Phe Single submitter ⚠
- p.Thr311Met Single submitter ⚠
- p.Thr470Ala Single submitter ⚠
- p.Thr93Met Single submitter ⚠
- p.Tyr89Cys Single submitter ⚠
- p.Val112Met Single submitter ⚠
- p.Val124Met Single submitter ⚠
- p.Val134Ala Single submitter ⚠
- p.Val134Ile Single submitter ⚠
- p.Val226Ala Single submitter ⚠
- p.Val226Met Single submitter ⚠
- p.Val256Met Single submitter ⚠
- p.Val31Ile Single submitter ⚠
- p.Val330Met Single submitter ⚠
- p.Val342Met Single submitter ⚠
- p.Val352Ile Single submitter ⚠
- p.Val425Ile Single submitter ⚠
- p.Val440Leu Single submitter ⚠
- p.Val469Met Single submitter ⚠
- p.Val471Met Single submitter ⚠