CD2BP2 — 60 ClinVar variants
All ClinVar germline CD2BP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
2 Likely benign · 58 Uncertain significance
Full CD2BP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD2BP2 p.Arg129Gln Uncertain significance Single submitter
- CD2BP2 p.Arg177Gly Uncertain significance Single submitter
- CD2BP2 p.Arg187Lys Uncertain significance Single submitter
- CD2BP2 p.Arg201Leu Uncertain significance Single submitter
- CD2BP2 p.Arg274Gln Uncertain significance Single submitter
- CD2BP2 p.Asp112Gly Uncertain significance Single submitter
- CD2BP2 p.Asp121Tyr Uncertain significance Single submitter
- CD2BP2 p.Gln235His Uncertain significance Single submitter
- CD2BP2 p.Gly10Ser Uncertain significance Single submitter
- CD2BP2 p.Gly275Arg Uncertain significance Single submitter
- CD2BP2 p.Gly83Ala Uncertain significance Single submitter
- CD2BP2 p.Gly99Ala Uncertain significance Single submitter
- CD2BP2 p.Gly99Val Uncertain significance Single submitter
- CD2BP2 p.His240Asp Uncertain significance Single submitter
- CD2BP2 p.Leu157Pro Uncertain significance Single submitter
- CD2BP2 p.Leu202His Uncertain significance Single submitter
- CD2BP2 p.Leu225Trp Uncertain significance Single submitter
- CD2BP2 p.Phe299Val Uncertain significance Single submitter
- CD2BP2 p.Pro239Ala Uncertain significance Single submitter
- CD2BP2 p.Pro246Ser Uncertain significance Single submitter
- CD2BP2 p.Pro263Ala Uncertain significance Single submitter
- CD2BP2 p.Ser194Gly Uncertain significance Single submitter
- CD2BP2 p.Ser273Leu Uncertain significance Single submitter
- CD2BP2 p.Tyr285Cys Uncertain significance Single submitter
- CD2BP2 p.Val171Gly Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- CD2BP2 p.Ala256Val Uncertain significance Single submitter
- CD2BP2 p.Ala67Val Uncertain significance Single submitter
- CD2BP2 p.Arg181Gln Uncertain significance Single submitter
- CD2BP2 p.Arg201Trp Uncertain significance Single submitter
- CD2BP2 p.Arg224Trp Uncertain significance Single submitter
- CD2BP2 p.Arg228Cys Uncertain significance Single submitter
- CD2BP2 p.Arg228Pro Uncertain significance Single submitter
- CD2BP2 p.Arg274Trp Uncertain significance Single submitter
- CD2BP2 p.Arg40Pro Uncertain significance Single submitter
- CD2BP2 p.Arg86Trp Uncertain significance Single submitter
- CD2BP2 p.Asp16Asn Uncertain significance Single submitter
- CD2BP2 p.Asp292Tyr Uncertain significance Single submitter
- CD2BP2 p.Asp323Tyr Uncertain significance Single submitter
- CD2BP2 p.Asp55His Uncertain significance Single submitter
- CD2BP2 p.Glu142Lys Uncertain significance Single submitter
- CD2BP2 p.Glu144Asp Uncertain significance Single submitter
- CD2BP2 p.Glu15Gly Uncertain significance Single submitter
- CD2BP2 p.Gly316Ser Uncertain significance Single submitter
- CD2BP2 p.Gly73Val Uncertain significance Single submitter
- CD2BP2 p.Ile87Val Uncertain significance Single submitter
- CD2BP2 p.Leu164Phe Uncertain significance Single submitter
- CD2BP2 p.Leu229Val Uncertain significance Single submitter
- CD2BP2 p.Leu47Val Uncertain significance Single submitter
- CD2BP2 p.Pro133Arg Uncertain significance Single submitter
- CD2BP2 p.Pro167Ser Uncertain significance Single submitter
- CD2BP2 p.Pro325Arg Uncertain significance Single submitter
- CD2BP2 p.Ser141Leu Uncertain significance Single submitter
- CD2BP2 p.Ser153Arg Uncertain significance Single submitter
- CD2BP2 p.Ser195Phe Uncertain significance Single submitter
- CD2BP2 p.Ser203Phe Uncertain significance Single submitter
- CD2BP2 p.Ser332Cys Uncertain significance Single submitter
- CD2BP2 p.Thr300Ile Uncertain significance Single submitter
- CD2BP2 p.Val126Ala Uncertain significance Single submitter
All CD2BP2 variants
Likely benign 2
- p.Arg136His Single submitter
- p.Ser309Asn Single submitter
Uncertain significance 58
- p.Ala256Val Single submitter ⚠
- p.Ala67Val Single submitter ⚠
- p.Arg129Gln Single submitter ⚠
- p.Arg177Gly Single submitter ⚠
- p.Arg181Gln Single submitter ⚠
- p.Arg187Lys Single submitter ⚠
- p.Arg201Leu Single submitter ⚠
- p.Arg201Trp Single submitter ⚠
- p.Arg224Trp Single submitter ⚠
- p.Arg228Cys Single submitter ⚠
- p.Arg228Pro Single submitter ⚠
- p.Arg274Gln Single submitter ⚠
- p.Arg274Trp Single submitter ⚠
- p.Arg40Pro Single submitter ⚠
- p.Arg86Trp Single submitter ⚠
- p.Asp112Gly Single submitter ⚠
- p.Asp121Tyr Single submitter ⚠
- p.Asp16Asn Single submitter ⚠
- p.Asp292Tyr Single submitter ⚠
- p.Asp323Tyr Single submitter ⚠
- p.Asp55His Single submitter ⚠
- p.Gln235His Single submitter ⚠
- p.Glu142Lys Single submitter ⚠
- p.Glu144Asp Single submitter ⚠
- p.Glu15Gly Single submitter ⚠
- p.Gly10Ser Single submitter ⚠
- p.Gly275Arg Single submitter ⚠
- p.Gly316Ser Single submitter ⚠
- p.Gly73Val Single submitter ⚠
- p.Gly83Ala Single submitter ⚠
- p.Gly99Ala Single submitter ⚠
- p.Gly99Val Single submitter ⚠
- p.His240Asp Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Leu157Pro Single submitter ⚠
- p.Leu164Phe Single submitter ⚠
- p.Leu202His Single submitter ⚠
- p.Leu225Trp Single submitter ⚠
- p.Leu229Val Single submitter ⚠
- p.Leu47Val Single submitter ⚠
- p.Phe299Val Single submitter ⚠
- p.Pro133Arg Single submitter ⚠
- p.Pro167Ser Single submitter ⚠
- p.Pro239Ala Single submitter ⚠
- p.Pro246Ser Single submitter ⚠
- p.Pro263Ala Single submitter ⚠
- p.Pro325Arg Single submitter ⚠
- p.Ser141Leu Single submitter ⚠
- p.Ser153Arg Single submitter ⚠
- p.Ser194Gly Single submitter ⚠
- p.Ser195Phe Single submitter ⚠
- p.Ser203Phe Single submitter ⚠
- p.Ser273Leu Single submitter ⚠
- p.Ser332Cys Single submitter ⚠
- p.Thr300Ile Single submitter ⚠
- p.Tyr285Cys Single submitter ⚠
- p.Val126Ala Single submitter ⚠
- p.Val171Gly Single submitter ⚠