CD300LG — 69 ClinVar variants
All ClinVar germline CD300LG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
4 Likely benign · 65 Uncertain significance
Full CD300LG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD300LG p.Ala142Pro Uncertain significance Single submitter
- CD300LG p.Ala179Ser Uncertain significance Single submitter
- CD300LG p.Ala181Val Uncertain significance Single submitter
- CD300LG p.Ala211Ser Uncertain significance Single submitter
- CD300LG p.Ala266Thr Uncertain significance Single submitter
- CD300LG p.Ala266Val Uncertain significance Single submitter
- CD300LG p.Ala332Ser Uncertain significance Single submitter
- CD300LG p.Arg112Gln Uncertain significance Single submitter
- CD300LG p.Arg145His Uncertain significance Single submitter
- CD300LG p.Arg247His Uncertain significance Single submitter
- CD300LG p.Arg294Cys Uncertain significance Single submitter
- CD300LG p.Arg2Trp Uncertain significance Single submitter
- CD300LG p.Arg60His Uncertain significance Single submitter
- CD300LG p.Gln174Pro Uncertain significance Single submitter
- CD300LG p.Gln197Arg Uncertain significance Single submitter
- CD300LG p.Gln219His Uncertain significance Single submitter
- CD300LG p.Glu288Lys Uncertain significance Single submitter
- CD300LG p.Glu301Lys Uncertain significance Single submitter
- CD300LG p.Gly212Arg Uncertain significance Single submitter
- CD300LG p.Gly309Ala Uncertain significance Single submitter
- CD300LG p.Lys149Asn Uncertain significance Single submitter
- CD300LG p.Lys48Asn Uncertain significance Single submitter
- CD300LG p.Met218Val Uncertain significance Single submitter
- CD300LG p.Pro131Leu Uncertain significance Single submitter
- CD300LG p.Pro216Ala Uncertain significance Single submitter
- CD300LG p.Pro217Arg Uncertain significance Single submitter
- CD300LG p.Pro217Leu Uncertain significance Single submitter
- CD300LG p.Pro244Leu Uncertain significance Single submitter
- CD300LG p.Pro315Leu Uncertain significance Single submitter
- CD300LG p.Pro316Leu Uncertain significance Single submitter
- CD300LG p.Ser208Pro Uncertain significance Single submitter
- CD300LG p.Ser236Thr Uncertain significance Single submitter
- CD300LG p.Ser313Leu Uncertain significance Single submitter
- CD300LG p.Thr187Ala Uncertain significance Single submitter
- CD300LG p.Val241Leu Uncertain significance Single submitter
- CD300LG p.Val254Leu Uncertain significance Single submitter
- CD300LG p.Val311Met Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- CD300LG p.Ala262Thr Likely benign Single submitter
- CD300LG p.Arg47Gln Uncertain significance Single submitter
- CD300LG p.Arg47Gly Uncertain significance Single submitter
- CD300LG p.Arg60Cys Uncertain significance Single submitter
- CD300LG p.Asp115Asn Uncertain significance Single submitter
- CD300LG p.Cys61Gly Uncertain significance Single submitter
- CD300LG p.Glu116Lys Uncertain significance Single submitter
- CD300LG p.Glu20Asp Uncertain significance Single submitter
- CD300LG p.Glu29Lys Uncertain significance Single submitter
- CD300LG p.Glu87Gln Uncertain significance Single submitter
- CD300LG p.Gly309Trp Uncertain significance Single submitter
- CD300LG p.Gly71Asp Uncertain significance Single submitter
- CD300LG p.Gly71Val Uncertain significance Single submitter
- CD300LG p.Leu13Phe Uncertain significance Single submitter
- CD300LG p.Leu160Phe Uncertain significance Single submitter
- CD300LG p.Leu256Pro Uncertain significance Single submitter
- CD300LG p.Phe125Leu Uncertain significance Single submitter
- CD300LG p.Pro126Ala Uncertain significance Single submitter
- CD300LG p.Pro22Ser Uncertain significance Single submitter
- CD300LG p.Ser121Ala Uncertain significance Single submitter
- CD300LG p.Ser234Cys Uncertain significance Single submitter
- CD300LG p.Ser34Phe Uncertain significance Single submitter
- CD300LG p.Ser34Pro Uncertain significance Single submitter
- CD300LG p.Ser34Tyr Uncertain significance Single submitter
- CD300LG p.Thr137Asn Uncertain significance Single submitter
- CD300LG p.Thr155Asn Uncertain significance Single submitter
- CD300LG p.Thr177Ile Uncertain significance Single submitter
- CD300LG p.Val79Met Uncertain significance Single submitter
- CD300LG p.Val92Met Uncertain significance Single submitter
All CD300LG variants
Likely benign 4
- p.Ala169Val Single submitter
- p.Ala262Thr Single submitter ⚠
- p.Ala306Asp Single submitter
- p.Pro217Ala Single submitter
Uncertain significance 65
- p.Ala142Pro Single submitter ⚠
- p.Ala179Ser Single submitter ⚠
- p.Ala181Val Single submitter ⚠
- p.Ala211Ser Single submitter ⚠
- p.Ala266Thr Single submitter ⚠
- p.Ala266Val Single submitter ⚠
- p.Ala332Ser Single submitter ⚠
- p.Arg112Gln Single submitter ⚠
- p.Arg145His Single submitter ⚠
- p.Arg247His Single submitter ⚠
- p.Arg294Cys Single submitter ⚠
- p.Arg2Trp Single submitter ⚠
- p.Arg47Gln Single submitter ⚠
- p.Arg47Gly Single submitter ⚠
- p.Arg60Cys Single submitter ⚠
- p.Arg60His Single submitter ⚠
- p.Asp115Asn Single submitter ⚠
- p.Cys61Gly Single submitter ⚠
- p.Gln174Pro Single submitter ⚠
- p.Gln197Arg Single submitter ⚠
- p.Gln219His Single submitter ⚠
- p.Glu116Lys Single submitter ⚠
- p.Glu20Asp Single submitter ⚠
- p.Glu288Lys Single submitter ⚠
- p.Glu29Lys Single submitter ⚠
- p.Glu301Lys Single submitter ⚠
- p.Glu87Gln Single submitter ⚠
- p.Gly212Arg Single submitter ⚠
- p.Gly309Ala Single submitter ⚠
- p.Gly309Trp Single submitter ⚠
- p.Gly71Asp Single submitter ⚠
- p.Gly71Val Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu160Phe Single submitter ⚠
- p.Leu256Pro Single submitter ⚠
- p.Lys149Asn Single submitter ⚠
- p.Lys48Asn Single submitter ⚠
- p.Met218Val Single submitter ⚠
- p.Phe125Leu Single submitter ⚠
- p.Pro126Ala Single submitter ⚠
- p.Pro131Leu Single submitter ⚠
- p.Pro216Ala Single submitter ⚠
- p.Pro217Arg Single submitter ⚠
- p.Pro217Leu Single submitter ⚠
- p.Pro22Ser Single submitter ⚠
- p.Pro244Leu Single submitter ⚠
- p.Pro315Leu Single submitter ⚠
- p.Pro316Leu Single submitter ⚠
- p.Ser121Ala Single submitter ⚠
- p.Ser208Pro Single submitter ⚠
- p.Ser234Cys Single submitter ⚠
- p.Ser236Thr Single submitter ⚠
- p.Ser313Leu Single submitter ⚠
- p.Ser34Phe Single submitter ⚠
- p.Ser34Pro Single submitter ⚠
- p.Ser34Tyr Single submitter ⚠
- p.Thr137Asn Single submitter ⚠
- p.Thr155Asn Single submitter ⚠
- p.Thr177Ile Single submitter ⚠
- p.Thr187Ala Single submitter ⚠
- p.Val241Leu Single submitter ⚠
- p.Val254Leu Single submitter ⚠
- p.Val311Met Single submitter ⚠
- p.Val79Met Single submitter ⚠
- p.Val92Met Single submitter ⚠