Sugi Variant

Sugi Variant/CD55

CD55 — 272 ClinVar variants

All ClinVar germline CD55 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 96 flagged for review →

16 Pathogenic · 1 Pathogenic/Likely pathogenic · 9 Likely pathogenic · 2 Conflicting · 8 Benign · 7 Benign/Likely benign · 123 Likely benign · 106 Uncertain significance

Full CD55 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 96

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors lean, ClinVar uncertain 42

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 53

The independent predictors disagree with each other — read with care.

All CD55 variants

Pathogenic 16

Pathogenic/Likely pathogenic 1

  • p.Glu50Ter Multiple submitters protein-losing enteropathy

Likely pathogenic 9

Conflicting classifications of pathogenicity 2

Benign 8

Benign/Likely benign 7

Likely benign 123

Uncertain significance 106