CD72 — 40 ClinVar variants
All ClinVar germline CD72 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
2 Likely benign · 38 Uncertain significance
Full CD72 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD72 p.Ala180Glu Uncertain significance Single submitter
- CD72 p.Ala269Val Uncertain significance Single submitter
- CD72 p.Ala4Thr Uncertain significance Single submitter
- CD72 p.Ala81Val Uncertain significance Single submitter
- CD72 p.Arg161Lys Uncertain significance Single submitter
- CD72 p.Arg84Leu Uncertain significance Single submitter
- CD72 p.Asp359His Uncertain significance Single submitter
- CD72 p.Gln258Lys Uncertain significance Single submitter
- CD72 p.Gln314Lys Uncertain significance Single submitter
- CD72 p.Gln321Leu Uncertain significance Single submitter
- CD72 p.Glu163Gln Uncertain significance Single submitter
- CD72 p.Glu182Gln Uncertain significance Single submitter
- CD72 p.Glu182Lys Uncertain significance Single submitter
- CD72 p.Gly99Asp Uncertain significance Single submitter
- CD72 p.Ile85Thr Uncertain significance Single submitter
- CD72 p.Leu337Val Uncertain significance Single submitter
- CD72 p.Lys146Arg Uncertain significance Single submitter
- CD72 p.Lys324Glu Uncertain significance Single submitter
- CD72 p.Ser293Leu Uncertain significance Single submitter
- CD72 p.Thr103Ile Uncertain significance Single submitter
- CD72 p.Thr135Asn Uncertain significance Single submitter
- CD72 p.Thr195Met Uncertain significance Single submitter
- CD72 p.Thr198Ser Uncertain significance Single submitter
- CD72 p.Thr331Ile Uncertain significance Single submitter
- CD72 p.Val328Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CD72 p.Ala2Gly Uncertain significance Single submitter
- CD72 p.Arg144Cys Uncertain significance Single submitter
- CD72 p.Asp191Gly Uncertain significance Single submitter
- CD72 p.Gln186Glu Uncertain significance Single submitter
- CD72 p.Gln258Arg Uncertain significance Single submitter
- CD72 p.Gln27His Uncertain significance Single submitter
- CD72 p.Gly236Arg Uncertain significance Single submitter
- CD72 p.Gly291Arg Uncertain significance Single submitter
- CD72 p.Gly291Cys Uncertain significance Single submitter
- CD72 p.His178Tyr Uncertain significance Single submitter
- CD72 p.Leu132Val Uncertain significance Single submitter
- CD72 p.Phe223Leu Likely benign Single submitter
- CD72 p.Thr148Met Uncertain significance Single submitter
- CD72 p.Trp254Leu Uncertain significance Single submitter
All CD72 variants
Likely benign 2
- p.Gly227Ser Single submitter
- p.Phe223Leu Single submitter ⚠
Uncertain significance 38
- p.Ala180Glu Single submitter ⚠
- p.Ala269Val Single submitter ⚠
- p.Ala2Gly Single submitter ⚠
- p.Ala4Thr Single submitter ⚠
- p.Ala81Val Single submitter ⚠
- p.Arg144Cys Single submitter ⚠
- p.Arg161Lys Single submitter ⚠
- p.Arg84Leu Single submitter ⚠
- p.Asp191Gly Single submitter ⚠
- p.Asp359His Single submitter ⚠
- p.Gln186Glu Single submitter ⚠
- p.Gln258Arg Single submitter ⚠
- p.Gln258Lys Single submitter ⚠
- p.Gln27His Single submitter ⚠
- p.Gln314Lys Single submitter ⚠
- p.Gln321Leu Single submitter ⚠
- p.Glu163Gln Single submitter ⚠
- p.Glu182Gln Single submitter ⚠
- p.Glu182Lys Single submitter ⚠
- p.Gly236Arg Single submitter ⚠
- p.Gly291Arg Single submitter ⚠
- p.Gly291Cys Single submitter ⚠
- p.Gly99Asp Single submitter ⚠
- p.His178Tyr Single submitter ⚠
- p.Ile85Thr Single submitter ⚠
- p.Leu132Val Single submitter ⚠
- p.Leu337Val Single submitter ⚠
- p.Lys146Arg Single submitter ⚠
- p.Lys324Glu Single submitter ⚠
- p.Ser293Leu Single submitter ⚠
- p.Thr103Ile Single submitter ⚠
- p.Thr135Asn Single submitter ⚠
- p.Thr148Met Single submitter ⚠
- p.Thr195Met Single submitter ⚠
- p.Thr198Ser Single submitter ⚠
- p.Thr331Ile Single submitter ⚠
- p.Trp254Leu Single submitter ⚠
- p.Val328Ile Single submitter ⚠