CD74 — 36 ClinVar variants
All ClinVar germline CD74 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
5 Likely benign · 31 Uncertain significance
Full CD74 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD74 p.Ala117Thr Uncertain significance Single submitter
- CD74 p.Arg108Gly Uncertain significance Single submitter
- CD74 p.Arg108His Uncertain significance Single submitter
- CD74 p.Arg167Ser Uncertain significance Single submitter
- CD74 p.Arg35Gly Uncertain significance Single submitter
- CD74 p.Cys9Ser Uncertain significance Single submitter
- CD74 p.Gln125Arg Uncertain significance Single submitter
- CD74 p.Met107Val Uncertain significance Single submitter
- CD74 p.Met109Leu Uncertain significance Single submitter
- CD74 p.Met109Val Uncertain significance Single submitter
- CD74 p.Met137Val Uncertain significance Single submitter
- CD74 p.Pro225Leu Uncertain significance Single submitter
- CD74 p.Pro280Gln Uncertain significance Single submitter
- CD74 p.Ser281Pro Uncertain significance Single submitter
- CD74 p.Thr263Ala Uncertain significance Single submitter
- CD74 p.Thr51Ala Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CD74 p.Arg46His Uncertain significance Single submitter
- CD74 p.Arg77Trp Uncertain significance Single submitter
- CD74 p.Arg94His Uncertain significance Single submitter
- CD74 p.Gly248Ser Uncertain significance Single submitter
- CD74 p.Gly63Ser Uncertain significance Single submitter
- CD74 p.Lys231Glu Uncertain significance Single submitter
- CD74 p.Lys99Asn Uncertain significance Single submitter
- CD74 p.Pro103Ser Uncertain significance Single submitter
- CD74 p.Pro156Leu Uncertain significance Single submitter
- CD74 p.Pro207Leu Uncertain significance Single submitter
- CD74 p.Pro255Arg Uncertain significance Single submitter
- CD74 p.Pro40Leu Uncertain significance Single submitter
- CD74 p.Ser282Tyr Uncertain significance Single submitter
- CD74 p.Thr211Pro Uncertain significance Single submitter
- CD74 p.Thr258Met Uncertain significance Single submitter
All CD74 variants
Likely benign 5
- c.881-3C>T Single submitter
- p.Arg10Gln Single submitter
- p.Gly38Arg Single submitter
- p.Pro280= Single submitter
- p.Val104Leu Single submitter
Uncertain significance 31
- p.Ala117Thr Single submitter ⚠
- p.Arg108Gly Single submitter ⚠
- p.Arg108His Single submitter ⚠
- p.Arg167Ser Single submitter ⚠
- p.Arg35Gly Single submitter ⚠
- p.Arg46His Single submitter ⚠
- p.Arg77Trp Single submitter ⚠
- p.Arg94His Single submitter ⚠
- p.Cys9Ser Single submitter ⚠
- p.Gln125Arg Single submitter ⚠
- p.Gly248Ser Single submitter ⚠
- p.Gly63Ser Single submitter ⚠
- p.Lys231Glu Single submitter ⚠
- p.Lys99Asn Single submitter ⚠
- p.Met107Val Single submitter ⚠
- p.Met109Leu Single submitter ⚠
- p.Met109Val Single submitter ⚠
- p.Met137Val Single submitter ⚠
- p.Pro103Ser Single submitter ⚠
- p.Pro156Leu Single submitter ⚠
- p.Pro207Leu Single submitter ⚠
- p.Pro225Leu Single submitter ⚠
- p.Pro255Arg Single submitter ⚠
- p.Pro280Gln Single submitter ⚠
- p.Pro40Leu Single submitter ⚠
- p.Ser281Pro Single submitter ⚠
- p.Ser282Tyr Single submitter ⚠
- p.Thr211Pro Single submitter ⚠
- p.Thr258Met Single submitter ⚠
- p.Thr263Ala Single submitter ⚠
- p.Thr51Ala Single submitter ⚠