CD84 — 55 ClinVar variants
All ClinVar germline CD84 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
4 Likely benign · 51 Uncertain significance
Full CD84 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD84 c.760+12C>T Uncertain significance Single submitter
- CD84 c.760+668A>G Uncertain significance Single submitter
- CD84 c.760+670C>G Uncertain significance Single submitter
- CD84 p.Ala216Thr Uncertain significance Single submitter
- CD84 p.Ala274Thr Uncertain significance Single submitter
- CD84 p.Ala71Thr Uncertain significance Single submitter
- CD84 p.Ala71Val Uncertain significance Single submitter
- CD84 p.Asn296Asp Uncertain significance Single submitter
- CD84 p.Asn93Ser Uncertain significance Single submitter
- CD84 p.Asp315Gly Uncertain significance Single submitter
- CD84 p.Gln114His Uncertain significance Single submitter
- CD84 p.Gln182His Uncertain significance Single submitter
- CD84 p.Gln284Arg Uncertain significance Single submitter
- CD84 p.Glu188Asp Uncertain significance Single submitter
- CD84 p.Glu275Gly Uncertain significance Single submitter
- CD84 p.Gly309Arg Uncertain significance Single submitter
- CD84 p.His222Tyr Uncertain significance Single submitter
- CD84 p.His5Leu Uncertain significance Single submitter
- CD84 p.Ile239Val Uncertain significance Single submitter
- CD84 p.Ile261Thr Uncertain significance Single submitter
- CD84 p.Ile265Thr Uncertain significance Single submitter
- CD84 p.Leu171Val Uncertain significance Single submitter
- CD84 p.Lys258Glu Uncertain significance Single submitter
- CD84 p.Lys286Arg Uncertain significance Single submitter
- CD84 p.Pro184Ala Uncertain significance Single submitter
- CD84 p.Pro294Ser Uncertain significance Single submitter
- CD84 p.Pro65Leu Uncertain significance Single submitter
- CD84 p.Pro90Leu Uncertain significance Single submitter
- CD84 p.Ser312Asn Uncertain significance Single submitter
- CD84 p.Thr321Asn Uncertain significance Single submitter
- CD84 p.Thr64Lys Uncertain significance Single submitter
- CD84 p.Tyr81Asp Uncertain significance Single submitter
- CD84 p.Tyr82Asp Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CD84 p.Arg123Cys Uncertain significance Single submitter
- CD84 p.Arg131Gln Uncertain significance Single submitter
- CD84 p.Arg209Trp Uncertain significance Single submitter
- CD84 p.Arg220Cys Uncertain significance Single submitter
- CD84 p.Arg251Gly Uncertain significance Single submitter
- CD84 p.Asn167Asp Uncertain significance Single submitter
- CD84 p.Asn93Tyr Uncertain significance Single submitter
- CD84 p.Glu301Lys Uncertain significance Single submitter
- CD84 p.Ile111Leu Uncertain significance Single submitter
- CD84 p.Ile128Phe Uncertain significance Single submitter
- CD84 p.Leu178Phe Uncertain significance Single submitter
- CD84 p.Pro198Ala Uncertain significance Single submitter
- CD84 p.Pro72Leu Uncertain significance Single submitter
- CD84 p.Ser169Asn Uncertain significance Single submitter
- CD84 p.Ser207Phe Uncertain significance Single submitter
- CD84 p.Val151Gly Uncertain significance Single submitter
- CD84 p.Val229Met Uncertain significance Single submitter
- CD84 p.Val302Met Uncertain significance Single submitter
All CD84 variants
Likely benign 4
- p.Arg220His Single submitter
- p.Asp98Asn Single submitter
- p.Met232Val Single submitter
- p.Ser300= Single submitter
Uncertain significance 51
- c.760+12C>T Single submitter ⚠
- c.760+668A>G Single submitter ⚠
- c.760+670C>G Single submitter ⚠
- p.Ala216Thr Single submitter ⚠
- p.Ala274Thr Single submitter ⚠
- p.Ala71Thr Single submitter ⚠
- p.Ala71Val Single submitter ⚠
- p.Arg123Cys Single submitter ⚠
- p.Arg131Gln Single submitter ⚠
- p.Arg209Trp Single submitter ⚠
- p.Arg220Cys Single submitter ⚠
- p.Arg251Gly Single submitter ⚠
- p.Asn167Asp Single submitter ⚠
- p.Asn296Asp Single submitter ⚠
- p.Asn93Ser Single submitter ⚠
- p.Asn93Tyr Single submitter ⚠
- p.Asp315Gly Single submitter ⚠
- p.Gln114His Single submitter ⚠
- p.Gln182His Single submitter ⚠
- p.Gln284Arg Single submitter ⚠
- p.Glu188Asp Single submitter ⚠
- p.Glu275Gly Single submitter ⚠
- p.Glu301Lys Single submitter ⚠
- p.Gly309Arg Single submitter ⚠
- p.His222Tyr Single submitter ⚠
- p.His5Leu Single submitter ⚠
- p.Ile111Leu Single submitter ⚠
- p.Ile128Phe Single submitter ⚠
- p.Ile239Val Single submitter ⚠
- p.Ile261Thr Single submitter ⚠
- p.Ile265Thr Single submitter ⚠
- p.Leu171Val Single submitter ⚠
- p.Leu178Phe Single submitter ⚠
- p.Lys258Glu Single submitter ⚠
- p.Lys286Arg Single submitter ⚠
- p.Pro184Ala Single submitter ⚠
- p.Pro198Ala Single submitter ⚠
- p.Pro294Ser Single submitter ⚠
- p.Pro65Leu Single submitter ⚠
- p.Pro72Leu Single submitter ⚠
- p.Pro90Leu Single submitter ⚠
- p.Ser169Asn Single submitter ⚠
- p.Ser207Phe Single submitter ⚠
- p.Ser312Asn Single submitter ⚠
- p.Thr321Asn Single submitter ⚠
- p.Thr64Lys Single submitter ⚠
- p.Tyr81Asp Single submitter ⚠
- p.Tyr82Asp Single submitter ⚠
- p.Val151Gly Single submitter ⚠
- p.Val229Met Single submitter ⚠
- p.Val302Met Single submitter ⚠