CDC123 — 39 ClinVar variants
All ClinVar germline CDC123 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
2 Benign · 2 Likely benign · 35 Uncertain significance
Full CDC123 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC123 p.Ala113Val Uncertain significance Single submitter
- CDC123 p.Ala279Thr Uncertain significance Single submitter
- CDC123 p.Ala319Thr Uncertain significance Single submitter
- CDC123 p.Arg142His Uncertain significance Single submitter
- CDC123 p.Arg167Gln Uncertain significance Single submitter
- CDC123 p.Arg210Leu Uncertain significance Single submitter
- CDC123 p.Asn95Ser Uncertain significance Single submitter
- CDC123 p.Asp336His Uncertain significance Single submitter
- CDC123 p.Cys159Tyr Uncertain significance Single submitter
- CDC123 p.Gln57His Uncertain significance Single submitter
- CDC123 p.Glu184Lys Uncertain significance Single submitter
- CDC123 p.Ile149Val Uncertain significance Single submitter
- CDC123 p.Ile188Thr Uncertain significance Single submitter
- CDC123 p.Ile265Met Uncertain significance Single submitter
- CDC123 p.Leu127Pro Uncertain significance Single submitter
- CDC123 p.Lys89Glu Uncertain significance Single submitter
- CDC123 p.Pro58Arg Uncertain significance Single submitter
- CDC123 p.Ser121Phe Uncertain significance Single submitter
- CDC123 p.Ser121Pro Uncertain significance Single submitter
- CDC123 p.Trp69Cys Uncertain significance Single submitter
- CDC123 p.Val242Leu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CDC123 p.Arg142Gly Uncertain significance Single submitter
- CDC123 p.Gln222Arg Uncertain significance Single submitter
- CDC123 p.Gln91Arg Uncertain significance Single submitter
- CDC123 p.Gly20Val Uncertain significance Single submitter
- CDC123 p.Ile160Met Likely benign Single submitter
- CDC123 p.Ile234Thr Uncertain significance Single submitter
- CDC123 p.Leu7Phe Uncertain significance Single submitter
- CDC123 p.Lys241Glu Uncertain significance Single submitter
- CDC123 p.Pro249Ala Uncertain significance Single submitter
- CDC123 p.Pro285Leu Uncertain significance Single submitter
- CDC123 p.Pro31Ser Uncertain significance Single submitter
- CDC123 p.Pro84Ser Uncertain significance Single submitter
- CDC123 p.Ser238Arg Uncertain significance Single submitter
- CDC123 p.Thr315Ala Uncertain significance Single submitter
- CDC123 p.Thr79Met Uncertain significance Single submitter
All CDC123 variants
Benign 2
- c.489+3A>C Multiple submitters
- c.847-4A>G Multiple submitters
Likely benign 2
- p.Asn271= Single submitter
- p.Ile160Met Single submitter ⚠
Uncertain significance 35
- p.Ala113Val Single submitter ⚠
- p.Ala279Thr Single submitter ⚠
- p.Ala319Thr Single submitter ⚠
- p.Arg142Gly Single submitter ⚠
- p.Arg142His Single submitter ⚠
- p.Arg167Gln Single submitter ⚠
- p.Arg210Leu Single submitter ⚠
- p.Asn95Ser Single submitter ⚠
- p.Asp336His Single submitter ⚠
- p.Cys159Tyr Single submitter ⚠
- p.Gln222Arg Single submitter ⚠
- p.Gln57His Single submitter ⚠
- p.Gln91Arg Single submitter ⚠
- p.Glu184Lys Single submitter ⚠
- p.Gly20Val Single submitter ⚠
- p.Ile149Val Single submitter ⚠
- p.Ile188Thr Single submitter ⚠
- p.Ile234Thr Single submitter ⚠
- p.Ile265Met Single submitter ⚠
- p.Leu127Pro Single submitter ⚠
- p.Leu7Phe Single submitter ⚠
- p.Lys241Glu Single submitter ⚠
- p.Lys89Glu Single submitter ⚠
- p.Pro249Ala Single submitter ⚠
- p.Pro285Leu Single submitter ⚠
- p.Pro31Ser Single submitter ⚠
- p.Pro58Arg Single submitter ⚠
- p.Pro84Ser Single submitter ⚠
- p.Ser121Phe Single submitter ⚠
- p.Ser121Pro Single submitter ⚠
- p.Ser238Arg Single submitter ⚠
- p.Thr315Ala Single submitter ⚠
- p.Thr79Met Single submitter ⚠
- p.Trp69Cys Single submitter ⚠
- p.Val242Leu Single submitter ⚠