CDC20B — 70 ClinVar variants
All ClinVar germline CDC20B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
6 Likely benign · 64 Uncertain significance
Full CDC20B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC20B p.Ala145Ser Uncertain significance Single submitter
- CDC20B p.Ala64Val Uncertain significance Single submitter
- CDC20B p.Arg200Gly Uncertain significance Single submitter
- CDC20B p.Arg7Leu Uncertain significance Single submitter
- CDC20B p.Asn262Asp Uncertain significance Single submitter
- CDC20B p.Asn262Ser Uncertain significance Single submitter
- CDC20B p.Asp341Asn Uncertain significance Single submitter
- CDC20B p.Asp88Ala Uncertain significance Single submitter
- CDC20B p.Gln162Pro Uncertain significance Single submitter
- CDC20B p.Gln78His Uncertain significance Single submitter
- CDC20B p.Gln94Arg Uncertain significance Single submitter
- CDC20B p.Gln94Glu Uncertain significance Single submitter
- CDC20B p.Gln94Pro Uncertain significance Single submitter
- CDC20B p.Glu155Gln Uncertain significance Single submitter
- CDC20B p.Gly104Arg Uncertain significance Single submitter
- CDC20B p.Gly295Arg Uncertain significance Single submitter
- CDC20B p.His224Gln Uncertain significance Single submitter
- CDC20B p.His494Arg Uncertain significance Single submitter
- CDC20B p.Ile212Thr Uncertain significance Single submitter
- CDC20B p.Ile216Thr Uncertain significance Single submitter
- CDC20B p.Ile419Phe Uncertain significance Single submitter
- CDC20B p.Leu217Pro Uncertain significance Single submitter
- CDC20B p.Leu352Val Uncertain significance Single submitter
- CDC20B p.Leu369Pro Uncertain significance Single submitter
- CDC20B p.Leu495Pro Uncertain significance Single submitter
- CDC20B p.Lys144Asn Uncertain significance Single submitter
- CDC20B p.Lys468Asn Uncertain significance Single submitter
- CDC20B p.Met407Arg Uncertain significance Single submitter
- CDC20B p.Pro365Leu Uncertain significance Single submitter
- CDC20B p.Ser120Pro Uncertain significance Single submitter
- CDC20B p.Ser133Thr Uncertain significance Single submitter
- CDC20B p.Ser203Thr Uncertain significance Single submitter
- CDC20B p.Ser215Pro Uncertain significance Single submitter
- CDC20B p.Ser389Asn Uncertain significance Single submitter
- CDC20B p.Ser443Ile Uncertain significance Single submitter
- CDC20B p.Ser63Phe Uncertain significance Single submitter
- CDC20B p.Ser87Phe Uncertain significance Single submitter
- CDC20B p.Ser89Cys Uncertain significance Single submitter
- CDC20B p.Thr127Asn Uncertain significance Single submitter
- CDC20B p.Thr50Ala Uncertain significance Single submitter
- CDC20B p.Trp363Arg Uncertain significance Single submitter
- CDC20B p.Trp516Gly Uncertain significance Single submitter
- CDC20B p.Tyr519Phe Uncertain significance Single submitter
- CDC20B p.Val297Glu Uncertain significance Single submitter
- CDC20B p.Val397Ile Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CDC20B p.Arg353Pro Uncertain significance Single submitter
- CDC20B p.Asn324Lys Uncertain significance Single submitter
- CDC20B p.Asp408Tyr Uncertain significance Single submitter
- CDC20B p.Asp500Tyr Uncertain significance Single submitter
- CDC20B p.Glu294Gln Uncertain significance Single submitter
- CDC20B p.Glu459Asp Uncertain significance Single submitter
- CDC20B p.Leu234Val Uncertain significance Single submitter
- CDC20B p.Leu497Phe Uncertain significance Single submitter
- CDC20B p.Lys283Glu Uncertain significance Single submitter
- CDC20B p.Lys396Glu Uncertain significance Single submitter
- CDC20B p.Met407Val Uncertain significance Single submitter
- CDC20B p.Phe485Leu Uncertain significance Single submitter
- CDC20B p.Pro219Ser Uncertain significance Single submitter
- CDC20B p.Pro394Leu Uncertain significance Single submitter
- CDC20B p.Ser480Phe Uncertain significance Single submitter
- CDC20B p.Thr380Ile Uncertain significance Single submitter
- CDC20B p.Thr475Ile Uncertain significance Single submitter
- CDC20B p.Tyr232Cys Uncertain significance Single submitter
- CDC20B p.Val106Met Uncertain significance Single submitter
All CDC20B variants
Likely benign 6
- p.Ala252Ser Single submitter
- p.Ala59Val Single submitter
- p.Arg353His Single submitter
- p.Lys113= Single submitter
- p.Ser208Arg Single submitter
- p.Tyr519Cys Single submitter
Uncertain significance 64
- p.Ala145Ser Single submitter ⚠
- p.Ala64Val Single submitter ⚠
- p.Arg200Gly Single submitter ⚠
- p.Arg353Pro Single submitter ⚠
- p.Arg7Leu Single submitter ⚠
- p.Asn262Asp Single submitter ⚠
- p.Asn262Ser Single submitter ⚠
- p.Asn324Lys Single submitter ⚠
- p.Asp341Asn Single submitter ⚠
- p.Asp408Tyr Single submitter ⚠
- p.Asp500Tyr Single submitter ⚠
- p.Asp88Ala Single submitter ⚠
- p.Gln162Pro Single submitter ⚠
- p.Gln78His Single submitter ⚠
- p.Gln94Arg Single submitter ⚠
- p.Gln94Glu Single submitter ⚠
- p.Gln94Pro Single submitter ⚠
- p.Glu155Gln Single submitter ⚠
- p.Glu294Gln Single submitter ⚠
- p.Glu459Asp Single submitter ⚠
- p.Gly104Arg Single submitter ⚠
- p.Gly295Arg Single submitter ⚠
- p.His224Gln Single submitter ⚠
- p.His494Arg Single submitter ⚠
- p.Ile212Thr Single submitter ⚠
- p.Ile216Thr Single submitter ⚠
- p.Ile419Phe Single submitter ⚠
- p.Leu217Pro Single submitter ⚠
- p.Leu234Val Single submitter ⚠
- p.Leu352Val Single submitter ⚠
- p.Leu369Pro Single submitter ⚠
- p.Leu495Pro Single submitter ⚠
- p.Leu497Phe Single submitter ⚠
- p.Lys144Asn Single submitter ⚠
- p.Lys283Glu Single submitter ⚠
- p.Lys396Glu Single submitter ⚠
- p.Lys468Asn Single submitter ⚠
- p.Met407Arg Single submitter ⚠
- p.Met407Val Single submitter ⚠
- p.Phe485Leu Single submitter ⚠
- p.Pro219Ser Single submitter ⚠
- p.Pro365Leu Single submitter ⚠
- p.Pro394Leu Single submitter ⚠
- p.Ser120Pro Single submitter ⚠
- p.Ser133Thr Single submitter ⚠
- p.Ser203Thr Single submitter ⚠
- p.Ser215Pro Single submitter ⚠
- p.Ser389Asn Single submitter ⚠
- p.Ser443Ile Single submitter ⚠
- p.Ser480Phe Single submitter ⚠
- p.Ser63Phe Single submitter ⚠
- p.Ser87Phe Single submitter ⚠
- p.Ser89Cys Single submitter ⚠
- p.Thr127Asn Single submitter ⚠
- p.Thr380Ile Single submitter ⚠
- p.Thr475Ile Single submitter ⚠
- p.Thr50Ala Single submitter ⚠
- p.Trp363Arg Single submitter ⚠
- p.Trp516Gly Single submitter ⚠
- p.Tyr232Cys Single submitter ⚠
- p.Tyr519Phe Single submitter ⚠
- p.Val106Met Single submitter ⚠
- p.Val297Glu Single submitter ⚠
- p.Val397Ile Single submitter ⚠