CDC42SE2 — 9 ClinVar variants
All ClinVar germline CDC42SE2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
9 Uncertain significance
Full CDC42SE2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 5
The independent predictors disagree with each other — read with care.
All CDC42SE2 variants
Uncertain significance 9
- p.Ala72Pro Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Asn58Tyr Single submitter ⚠
- p.Gln15His Single submitter ⚠
- p.Ile56Leu Single submitter ⚠
- p.Leu78His Single submitter ⚠
- p.Phe4Tyr Single submitter ⚠
- p.Ser43Leu Single submitter ⚠
- p.Ser52Pro Single submitter ⚠