CDCA2 — 152 ClinVar variants
All ClinVar germline CDCA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 133 flagged for review →
4 Benign · 15 Likely benign · 133 Uncertain significance
Full CDCA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 133
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 94
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDCA2 p.Val467Ile Uncertain significance Multiple submitters
- CDCA2 p.Ala187Thr Uncertain significance Single submitter
- CDCA2 p.Ala217Val Uncertain significance Single submitter
- CDCA2 p.Ala23Val Uncertain significance Single submitter
- CDCA2 p.Ala92Gly Uncertain significance Single submitter
- CDCA2 p.Arg106His Uncertain significance Single submitter
- CDCA2 p.Arg136Gln Uncertain significance Single submitter
- CDCA2 p.Arg415Cys Uncertain significance Single submitter
- CDCA2 p.Arg415Leu Uncertain significance Single submitter
- CDCA2 p.Arg640His Uncertain significance Single submitter
- CDCA2 p.Arg721Cys Uncertain significance Single submitter
- CDCA2 p.Arg781Cys Uncertain significance Single submitter
- CDCA2 p.Asn454Ser Uncertain significance Single submitter
- CDCA2 p.Asn490Asp Uncertain significance Single submitter
- CDCA2 p.Asn631Asp Uncertain significance Single submitter
- CDCA2 p.Asn696Lys Uncertain significance Single submitter
- CDCA2 p.Asn760Asp Uncertain significance Single submitter
- CDCA2 p.Asn760Ser Uncertain significance Single submitter
- CDCA2 p.Asn785Ile Uncertain significance Single submitter
- CDCA2 p.Asn785Thr Uncertain significance Single submitter
- CDCA2 p.Asn885Ser Uncertain significance Single submitter
- CDCA2 p.Asp279Asn Uncertain significance Single submitter
- CDCA2 p.Asp354Glu Uncertain significance Single submitter
- CDCA2 p.Asp425Gly Uncertain significance Single submitter
- CDCA2 p.Asp969Asn Uncertain significance Single submitter
- CDCA2 p.Cys347Arg Uncertain significance Single submitter
- CDCA2 p.Cys790Tyr Uncertain significance Single submitter
- CDCA2 p.Cys87Arg Uncertain significance Single submitter
- CDCA2 p.Gln574Arg Uncertain significance Single submitter
- CDCA2 p.Gln744Arg Uncertain significance Single submitter
- CDCA2 p.Glu1006Asp Uncertain significance Single submitter
- CDCA2 p.Glu1013Gly Uncertain significance Single submitter
- CDCA2 p.Glu345Lys Uncertain significance Single submitter
- CDCA2 p.Glu519Asp Uncertain significance Single submitter
- CDCA2 p.Glu534Ala Uncertain significance Single submitter
- CDCA2 p.Glu624Lys Uncertain significance Single submitter
- CDCA2 p.Glu699Lys Uncertain significance Single submitter
- CDCA2 p.Glu903Lys Uncertain significance Single submitter
- CDCA2 p.Gly184Cys Uncertain significance Single submitter
- CDCA2 p.Gly452Glu Uncertain significance Single submitter
- CDCA2 p.Gly650Asp Uncertain significance Single submitter
- CDCA2 p.Gly66Arg Uncertain significance Single submitter
- CDCA2 p.Gly670Ser Uncertain significance Single submitter
- CDCA2 p.Ile361Val Uncertain significance Single submitter
- CDCA2 p.Ile476Val Uncertain significance Single submitter
- CDCA2 p.Ile495Met Uncertain significance Single submitter
- CDCA2 p.Ile503Met Uncertain significance Single submitter
- CDCA2 p.Ile609Val Uncertain significance Single submitter
- CDCA2 p.Ile663Val Uncertain significance Single submitter
- CDCA2 p.Ile682Val Uncertain significance Single submitter
- CDCA2 p.Leu319Phe Uncertain significance Single submitter
- CDCA2 p.Leu759Val Uncertain significance Single submitter
- CDCA2 p.Lys276Arg Uncertain significance Single submitter
- CDCA2 p.Lys284Arg Uncertain significance Single submitter
- CDCA2 p.Lys571Arg Uncertain significance Single submitter
- CDCA2 p.Lys636Asn Uncertain significance Single submitter
- CDCA2 p.Lys705Asn Uncertain significance Single submitter
- CDCA2 p.Lys728Thr Uncertain significance Single submitter
- CDCA2 p.Lys846Arg Uncertain significance Single submitter
- CDCA2 p.Met950Leu Uncertain significance Single submitter
- CDCA2 p.Met950Val Uncertain significance Single submitter
- CDCA2 p.Phe325Ser Uncertain significance Single submitter
- CDCA2 p.Phe739Val Uncertain significance Single submitter
- CDCA2 p.Pro10Ser Uncertain significance Single submitter
- CDCA2 p.Pro127Ser Uncertain significance Single submitter
- CDCA2 p.Pro320Leu Uncertain significance Single submitter
- CDCA2 p.Pro358Leu Uncertain significance Single submitter
- CDCA2 p.Pro382Ser Uncertain significance Single submitter
- CDCA2 p.Pro413Ala Uncertain significance Single submitter
- CDCA2 p.Pro42Ser Uncertain significance Single submitter
- CDCA2 p.Pro711Arg Uncertain significance Single submitter
- CDCA2 p.Pro784Thr Uncertain significance Single submitter
- CDCA2 p.Pro9Ser Uncertain significance Single submitter
- CDCA2 p.Ser1007Asn Uncertain significance Single submitter
- CDCA2 p.Ser174Pro Uncertain significance Single submitter
- CDCA2 p.Ser266Leu Uncertain significance Single submitter
- CDCA2 p.Ser335Pro Uncertain significance Single submitter
- CDCA2 p.Ser515Asn Uncertain significance Single submitter
- CDCA2 p.Ser572Asn Uncertain significance Single submitter
- CDCA2 p.Ser818Gly Uncertain significance Single submitter
- CDCA2 p.Ser977Thr Uncertain significance Single submitter
- CDCA2 p.Thr271Ser Uncertain significance Single submitter
- CDCA2 p.Thr527Ile Uncertain significance Single submitter
- CDCA2 p.Thr680Arg Uncertain significance Single submitter
- CDCA2 p.Thr801Arg Uncertain significance Single submitter
- CDCA2 p.Tyr662Cys Uncertain significance Single submitter
- CDCA2 p.Tyr836Phe Uncertain significance Single submitter
- CDCA2 p.Tyr995Phe Uncertain significance Single submitter
- CDCA2 p.Val463Ile Uncertain significance Single submitter
- CDCA2 p.Val796Ala Uncertain significance Single submitter
- CDCA2 p.Val856Ala Uncertain significance Single submitter
- CDCA2 p.Val942Leu Uncertain significance Single submitter
- CDCA2 p.Val954Ile Uncertain significance Single submitter
-
CDCA2 p.Asp232Glu
Uncertain significance
No assertion criteria
myoepithelial tumor
Predictors split 39
The independent predictors disagree with each other — read with care.
- CDCA2 p.Arg144Gln Uncertain significance Single submitter
- CDCA2 p.Arg202Gln Uncertain significance Single submitter
- CDCA2 p.Arg328His Uncertain significance Single submitter
- CDCA2 p.Arg581Gly Uncertain significance Single submitter
- CDCA2 p.Arg891Gln Uncertain significance Single submitter
- CDCA2 p.Arg90Cys Uncertain significance Single submitter
- CDCA2 p.Arg974Gly Uncertain significance Single submitter
- CDCA2 p.Arg996Gln Uncertain significance Single submitter
- CDCA2 p.Arg996Trp Uncertain significance Single submitter
- CDCA2 p.Asn378Asp Uncertain significance Single submitter
- CDCA2 p.Asn411Asp Uncertain significance Single submitter
- CDCA2 p.Asn526His Uncertain significance Single submitter
- CDCA2 p.Asn885His Uncertain significance Single submitter
- CDCA2 p.Asp279Tyr Uncertain significance Single submitter
- CDCA2 p.Asp969Tyr Uncertain significance Single submitter
- CDCA2 p.Cys280Tyr Uncertain significance Single submitter
- CDCA2 p.Glu157Lys Uncertain significance Single submitter
- CDCA2 p.Glu595Lys Uncertain significance Single submitter
- CDCA2 p.Gly396Val Uncertain significance Single submitter
- CDCA2 p.Gly579Arg Uncertain significance Single submitter
- CDCA2 p.Ile105Met Uncertain significance Single submitter
- CDCA2 p.Ile155Met Uncertain significance Single submitter
- CDCA2 p.Leu513Phe Uncertain significance Single submitter
- CDCA2 p.Leu525Phe Uncertain significance Single submitter
- CDCA2 p.Lys541Glu Uncertain significance Single submitter
- CDCA2 p.Lys627Met Uncertain significance Single submitter
- CDCA2 p.Lys828Asn Uncertain significance Single submitter
- CDCA2 p.Pro313Ala Uncertain significance Single submitter
- CDCA2 p.Pro35Ser Uncertain significance Single submitter
- CDCA2 p.Pro401Leu Uncertain significance Single submitter
- CDCA2 p.Ser120Pro Uncertain significance Single submitter
- CDCA2 p.Ser240Tyr Uncertain significance Single submitter
- CDCA2 p.Ser427Gly Uncertain significance Single submitter
- CDCA2 p.Ser507Phe Uncertain significance Single submitter
- CDCA2 p.Ser863Ile Uncertain significance Single submitter
- CDCA2 p.Thr59Ile Uncertain significance Single submitter
- CDCA2 p.Thr68Ile Uncertain significance Single submitter
- CDCA2 p.Val277Phe Uncertain significance Single submitter
- CDCA2 p.Val290Ile Uncertain significance Single submitter
All CDCA2 variants
Benign 4
- p.Lys754Thr Multiple submitters
- p.Ser291= Multiple submitters
- p.Thr50Ile Multiple submitters
- p.Lys533= Single submitter
Likely benign 15
- p.Ala23Thr Single submitter
- p.Ala3Thr Single submitter
- p.Ala723Val Single submitter
- p.Arg640Pro Single submitter
- p.Asn228Ser Single submitter
- p.Asn902= Single submitter
- p.Asp318= Single submitter
- p.Gly567Ala Single submitter
- p.Ile222Thr Single submitter
- p.Met17Val Single submitter
- p.Pro292Leu Single submitter
- p.Pro43Leu Single submitter
- p.Ser668Leu Single submitter
- p.Tyr206Ser Single submitter
- p.Tyr351Cys Single submitter
Uncertain significance 133
- p.Val467Ile Multiple submitters ⚠
- p.Ala187Thr Single submitter ⚠
- p.Ala217Val Single submitter ⚠
- p.Ala23Val Single submitter ⚠
- p.Ala92Gly Single submitter ⚠
- p.Arg106His Single submitter ⚠
- p.Arg136Gln Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg202Gln Single submitter ⚠
- p.Arg328His Single submitter ⚠
- p.Arg415Cys Single submitter ⚠
- p.Arg415Leu Single submitter ⚠
- p.Arg581Gly Single submitter ⚠
- p.Arg640His Single submitter ⚠
- p.Arg721Cys Single submitter ⚠
- p.Arg781Cys Single submitter ⚠
- p.Arg891Gln Single submitter ⚠
- p.Arg90Cys Single submitter ⚠
- p.Arg974Gly Single submitter ⚠
- p.Arg996Gln Single submitter ⚠
- p.Arg996Trp Single submitter ⚠
- p.Asn378Asp Single submitter ⚠
- p.Asn411Asp Single submitter ⚠
- p.Asn454Ser Single submitter ⚠
- p.Asn490Asp Single submitter ⚠
- p.Asn526His Single submitter ⚠
- p.Asn631Asp Single submitter ⚠
- p.Asn696Lys Single submitter ⚠
- p.Asn760Asp Single submitter ⚠
- p.Asn760Ser Single submitter ⚠
- p.Asn785Ile Single submitter ⚠
- p.Asn785Thr Single submitter ⚠
- p.Asn885His Single submitter ⚠
- p.Asn885Ser Single submitter ⚠
- p.Asp279Asn Single submitter ⚠
- p.Asp279Tyr Single submitter ⚠
- p.Asp354Glu Single submitter ⚠
- p.Asp425Gly Single submitter ⚠
- p.Asp969Asn Single submitter ⚠
- p.Asp969Tyr Single submitter ⚠
- p.Cys280Tyr Single submitter ⚠
- p.Cys347Arg Single submitter ⚠
- p.Cys790Tyr Single submitter ⚠
- p.Cys87Arg Single submitter ⚠
- p.Gln574Arg Single submitter ⚠
- p.Gln744Arg Single submitter ⚠
- p.Glu1006Asp Single submitter ⚠
- p.Glu1013Gly Single submitter ⚠
- p.Glu157Lys Single submitter ⚠
- p.Glu345Lys Single submitter ⚠
- p.Glu519Asp Single submitter ⚠
- p.Glu534Ala Single submitter ⚠
- p.Glu595Lys Single submitter ⚠
- p.Glu624Lys Single submitter ⚠
- p.Glu699Lys Single submitter ⚠
- p.Glu903Lys Single submitter ⚠
- p.Gly184Cys Single submitter ⚠
- p.Gly396Val Single submitter ⚠
- p.Gly452Glu Single submitter ⚠
- p.Gly579Arg Single submitter ⚠
- p.Gly650Asp Single submitter ⚠
- p.Gly66Arg Single submitter ⚠
- p.Gly670Ser Single submitter ⚠
- p.Ile105Met Single submitter ⚠
- p.Ile155Met Single submitter ⚠
- p.Ile361Val Single submitter ⚠
- p.Ile476Val Single submitter ⚠
- p.Ile495Met Single submitter ⚠
- p.Ile503Met Single submitter ⚠
- p.Ile609Val Single submitter ⚠
- p.Ile663Val Single submitter ⚠
- p.Ile682Val Single submitter ⚠
- p.Leu319Phe Single submitter ⚠
- p.Leu513Phe Single submitter ⚠
- p.Leu525Phe Single submitter ⚠
- p.Leu759Val Single submitter ⚠
- p.Lys276Arg Single submitter ⚠
- p.Lys284Arg Single submitter ⚠
- p.Lys541Glu Single submitter ⚠
- p.Lys571Arg Single submitter ⚠
- p.Lys627Met Single submitter ⚠
- p.Lys636Asn Single submitter ⚠
- p.Lys705Asn Single submitter ⚠
- p.Lys728Thr Single submitter ⚠
- p.Lys828Asn Single submitter ⚠
- p.Lys846Arg Single submitter ⚠
- p.Met950Leu Single submitter ⚠
- p.Met950Val Single submitter ⚠
- p.Phe325Ser Single submitter ⚠
- p.Phe739Val Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro127Ser Single submitter ⚠
- p.Pro313Ala Single submitter ⚠
- p.Pro320Leu Single submitter ⚠
- p.Pro358Leu Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro382Ser Single submitter ⚠
- p.Pro401Leu Single submitter ⚠
- p.Pro413Ala Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Pro711Arg Single submitter ⚠
- p.Pro784Thr Single submitter ⚠
- p.Pro9Ser Single submitter ⚠
- p.Ser1007Asn Single submitter ⚠
- p.Ser120Pro Single submitter ⚠
- p.Ser174Pro Single submitter ⚠
- p.Ser240Tyr Single submitter ⚠
- p.Ser266Leu Single submitter ⚠
- p.Ser335Pro Single submitter ⚠
- p.Ser427Gly Single submitter ⚠
- p.Ser507Phe Single submitter ⚠
- p.Ser515Asn Single submitter ⚠
- p.Ser572Asn Single submitter ⚠
- p.Ser818Gly Single submitter ⚠
- p.Ser863Ile Single submitter ⚠
- p.Ser977Thr Single submitter ⚠
- p.Thr271Ser Single submitter ⚠
- p.Thr527Ile Single submitter ⚠
- p.Thr59Ile Single submitter ⚠
- p.Thr680Arg Single submitter ⚠
- p.Thr68Ile Single submitter ⚠
- p.Thr801Arg Single submitter ⚠
- p.Tyr662Cys Single submitter ⚠
- p.Tyr836Phe Single submitter ⚠
- p.Tyr995Phe Single submitter ⚠
- p.Val277Phe Single submitter ⚠
- p.Val290Ile Single submitter ⚠
- p.Val463Ile Single submitter ⚠
- p.Val796Ala Single submitter ⚠
- p.Val856Ala Single submitter ⚠
- p.Val942Leu Single submitter ⚠
- p.Val954Ile Single submitter ⚠
- p.Asp232Glu No assertion criteria myoepithelial tumor ⚠