CDCA3 — 34 ClinVar variants
All ClinVar germline CDCA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
1 Likely benign · 33 Uncertain significance
Full CDCA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDCA3 p.Ala12Gly Uncertain significance Single submitter
- CDCA3 p.Arg173Gly Uncertain significance Single submitter
- CDCA3 p.Arg23Gly Uncertain significance Single submitter
- CDCA3 p.Arg241Leu Uncertain significance Single submitter
- CDCA3 p.Arg241Pro Uncertain significance Single submitter
- CDCA3 p.Asn18Ser Uncertain significance Single submitter
- CDCA3 p.Asn227Asp Uncertain significance Single submitter
- CDCA3 p.Asp174Asn Uncertain significance Single submitter
- CDCA3 p.Glu100Gln Uncertain significance Single submitter
- CDCA3 p.Gly211Asp Uncertain significance Single submitter
- CDCA3 p.Gly52Arg Uncertain significance Single submitter
- CDCA3 p.Gly72Arg Uncertain significance Single submitter
- CDCA3 p.Gly72Asp Uncertain significance Single submitter
- CDCA3 p.Leu126Pro Uncertain significance Single submitter
- CDCA3 p.Lys194Arg Uncertain significance Single submitter
- CDCA3 p.Met136Thr Uncertain significance Single submitter
- CDCA3 p.Met184Ile Uncertain significance Single submitter
- CDCA3 p.Met78Val Uncertain significance Single submitter
- CDCA3 p.Phe144Ser Uncertain significance Single submitter
- CDCA3 p.Pro114Gln Uncertain significance Single submitter
- CDCA3 p.Pro137Ser Uncertain significance Single submitter
- CDCA3 p.Pro162Ser Uncertain significance Single submitter
- CDCA3 p.Pro47Ser Uncertain significance Single submitter
- CDCA3 p.Ser120Ala Uncertain significance Single submitter
- CDCA3 p.Val132Phe Uncertain significance Single submitter
- CDCA3 p.Val96Ile Uncertain significance Single submitter
- CDCA3 p.Val9Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CDCA3 p.Arg185His Uncertain significance Single submitter
- CDCA3 p.Arg220Trp Uncertain significance Single submitter
- CDCA3 p.Arg67Cys Uncertain significance Single submitter
- CDCA3 p.Ile39Val Uncertain significance Single submitter
- CDCA3 p.Pro210His Uncertain significance Single submitter
- CDCA3 p.Thr142Ile Uncertain significance Single submitter
All CDCA3 variants
Likely benign 1
- p.Ser172Leu Single submitter
Uncertain significance 33
- p.Ala12Gly Single submitter ⚠
- p.Arg173Gly Single submitter ⚠
- p.Arg185His Single submitter ⚠
- p.Arg220Trp Single submitter ⚠
- p.Arg23Gly Single submitter ⚠
- p.Arg241Leu Single submitter ⚠
- p.Arg241Pro Single submitter ⚠
- p.Arg67Cys Single submitter ⚠
- p.Asn18Ser Single submitter ⚠
- p.Asn227Asp Single submitter ⚠
- p.Asp174Asn Single submitter ⚠
- p.Glu100Gln Single submitter ⚠
- p.Gly211Asp Single submitter ⚠
- p.Gly52Arg Single submitter ⚠
- p.Gly72Arg Single submitter ⚠
- p.Gly72Asp Single submitter ⚠
- p.Ile39Val Single submitter ⚠
- p.Leu126Pro Single submitter ⚠
- p.Lys194Arg Single submitter ⚠
- p.Met136Thr Single submitter ⚠
- p.Met184Ile Single submitter ⚠
- p.Met78Val Single submitter ⚠
- p.Phe144Ser Single submitter ⚠
- p.Pro114Gln Single submitter ⚠
- p.Pro137Ser Single submitter ⚠
- p.Pro162Ser Single submitter ⚠
- p.Pro210His Single submitter ⚠
- p.Pro47Ser Single submitter ⚠
- p.Ser120Ala Single submitter ⚠
- p.Thr142Ile Single submitter ⚠
- p.Val132Phe Single submitter ⚠
- p.Val96Ile Single submitter ⚠
- p.Val9Ala Single submitter ⚠