CDH1 — 4587 ClinVar variants

All ClinVar germline CDH1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 2226 flagged for review →

403 Pathogenic · 34 Pathogenic/Likely pathogenic · 107 Likely pathogenic · 455 Conflicting · 174 Benign · 353 Benign/Likely benign · 907 Likely benign · 2154 Uncertain significance

Full CDH1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 2226

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 7

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

CDH1 p.Arg732Gln Pathogenic Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Glu353Lys Likely pathogenic Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr560Arg Pathogenic Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr568Arg Likely pathogenic Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Ala634Val Pathogenic/Likely pathogenic Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Gly571Ser Likely pathogenic Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn315Ser Likely pathogenic Single submitter
hereditary neoplastic syndrome

Predictors agree, ClinVar conflicts 160

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification. · showing the 150 best-reviewed of 160

CDH1 p.Ala102Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala10Thr Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala130Asp Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala137Pro Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala137Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala241Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala301Val Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala401Asp Conflicting Single submitter
CDH1-related disorder
CDH1 p.Ala634Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala636Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala636Val Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala67Asp Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala67Gly Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala67Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala691Thr Conflicting Single submitter
ovarian cancer
CDH1 p.Ala691Val Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala692Thr Conflicting Single submitter
hereditary breast carcinoma
CDH1 p.Ala698Pro Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala735Glu Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ala735Gly Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Arg124Pro Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Arg224Leu Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Arg492Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Arg50His Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Arg524Gly Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Arg598Gln Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Arg779Trp Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Arg796Gln Conflicting Single submitter
hereditary breast carcinoma
CDH1 p.Arg868Cys Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Arg868His Conflicting Single submitter
hereditary breast carcinoma
CDH1 p.Asn117Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asn144Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asn240Ser Conflicting Single submitter
CDH1-related disorder
CDH1 p.Asn376Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asn390Asp Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asn405Asp Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asn405Lys Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asn666His Conflicting Single submitter
hereditary breast carcinoma
CDH1 p.Asn666Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asn751Lys Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asn867Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asp221Gly Conflicting Single submitter
blepharocheilodontic syndrome 1
CDH1 p.Asp254Asn Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp291Asn Conflicting Single submitter
hereditary breast carcinoma
CDH1 p.Asp308Glu Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asp313Glu Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp313His Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asp313Tyr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asp400Asn Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp419Asn Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asp498Asn Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asp538Asn Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asp644Asn Conflicting Single submitter
hereditary breast carcinoma
CDH1 p.Asp676Asn Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Asp750Gly Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Gln351Arg Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Gln422Arg Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Gln95Glu Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Glu218Lys Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Glu310Gly Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Glu388Gln Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Glu445Ala Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Glu512Asp Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Glu58Lys Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Glu648Asp Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Glu745Asp Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Glu757Lys Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Glu758Gly Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Glu852Ala Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Gly134Arg Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Gly186Val Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Gly420Asp Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Gly759Ala Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.His121Arg Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.His121Asn Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.His123Gln Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.His128Arg Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.His632Arg Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.His92Gln Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.His97Asp Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile135Asn Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile319Val Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile393Val Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile415Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile415Val Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile435Val Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile451Leu Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile451Val Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile485Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile566Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile566Val Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile594Val Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile615Phe Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile615Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile615Val Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ile651Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ile651Val Conflicting Single submitter
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Ile96Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Leu276Pro Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Leu311Ile Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Leu669Val Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Leu71Phe Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Leu791Phe Conflicting Single submitter
hereditary breast carcinoma
CDH1 p.Leu872Pro Conflicting Single submitter
ovarian cancer
CDH1 p.Lys381Asn Conflicting Single submitter
hereditary breast carcinoma
CDH1 p.Lys557Arg Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Lys653Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Lys697Arg Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Lys86Arg Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Met272Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Met282Ile Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Met517Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Met670Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Phe338Ser Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Pro125Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Pro126Arg Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Pro126Leu Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Pro126Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Pro143Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Pro147Arg Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Pro201Arg Conflicting Single submitter
CDH1-related disorder
CDH1 p.Pro385Ala Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Pro593Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Pro825Leu Conflicting Single submitter
blepharocheilodontic syndrome 1
CDH1 p.Ser19Pro Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ser327Thr Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ser36Asn Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Ser9Leu Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr118Ala Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr199Lys Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr199Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr295Asn Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr303Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr318Ile Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr340Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr366Ser Conflicting Single submitter
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr368Ile Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr368Ser Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr394Ala Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr457Met Conflicting Single submitter
blepharocheilodontic syndrome 1
CDH1 p.Thr529Asn Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 p.Thr529Pro Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr568Ala Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr599Ala Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr61Ala Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr646Ala Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr73Asn Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr790Ile Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Thr79Ala Conflicting Single submitter
hereditary neoplastic syndrome
CDH1 p.Trp20Ser Conflicting Single submitter
hereditary neoplastic syndrome

Predicted LoF vs a conflicting call 2

ClinVar submitters conflict, and it's a predicted loss-of-function change in a gene where LoF causes disease — flagged for review, not resolved (verify NMD-escape for C-terminal truncations). Non-missense.

CDH1 c.1320+1G>A Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma
CDH1 c.164-1G>A Conflicting Single submitter
hereditary diffuse gastric adenocarcinoma

Predictors lean, ClinVar uncertain 1024

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 1024

CDH1 p.Ala455Thr Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Arg749Trp Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Asp254His Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Asp538Val Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Glu26Gln Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Glu35Asp Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Gly212Val Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Gly2Val Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.His121Gln Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Leu21Val Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Lys179Glu Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Phe171Cys Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Phe205Ser Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Pro27Ser Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Pro3Ser Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr529Ala Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Ala10Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala130Gly Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala130Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala137Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala286Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala298Asp Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala298Pro Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala298Val Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala347Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala34Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala389Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala403Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala446Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala446Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala455Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala510Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala541Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala546Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala563Val Uncertain significance Multiple submitters
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Ala567Val Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala592Ser Uncertain significance Multiple submitters
hereditary breast carcinoma
CDH1 p.Ala617Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala634Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala691Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala698Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala735Thr Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala778Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala778Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala788Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala788Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala802Gly Uncertain significance Multiple submitters
hereditary breast carcinoma
CDH1 p.Ala802Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala817Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala824Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala824Val Uncertain significance Multiple submitters
hereditary breast carcinoma
CDH1 p.Ala873Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala873Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg151Ile Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg222Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg224Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg335Gly Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Arg492Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg50Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg524Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg550Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg550Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg550Thr Uncertain significance Multiple submitters
ovarian cancer
CDH1 p.Arg598Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg65Lys Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Arg696Lys Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Arg6Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg733Ser Uncertain significance Multiple submitters
ovarian cancer
CDH1 p.Arg779Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg784Cys Uncertain significance Multiple submitters
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Arg784Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg784Leu Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Arg784Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg800Cys Uncertain significance Multiple submitters
hereditary breast carcinoma
CDH1 p.Arg800Leu Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Arg868Ser Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Arg87Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn117Ile Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn166Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn174Ser Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asn238Ser Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asn322Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn369Ser Uncertain significance Multiple submitters
hereditary breast carcinoma
CDH1 p.Asn371Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn376Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn432Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn570Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn589Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn591Asp Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asn613Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn622Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn622Ile Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asn622Tyr Uncertain significance Multiple submitters
hereditary breast carcinoma
CDH1 p.Asn643Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn643Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn672Ser Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asn814Ser Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asn849Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp104Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp198His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp198Val Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp288Asn Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp291Gly Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp292Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp308Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp308Val Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp313Val Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp334Glu Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp334Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp370Asn Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp418Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp443Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp479Glu Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp479Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp479His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp569Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp590Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp590Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp676Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp72His Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp72Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp750Asn Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp756Gly Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp756His Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp764Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp764Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp766His Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp766Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp768Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp80His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp812His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp834Asn Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp854Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp854Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp856Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp858His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp874His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp882Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Cys163Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Cys163Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Cys28Tyr Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Cys603Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Cys688Tyr Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Cys695Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Gln136Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Gln136Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Gln16Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Gln255Arg Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Gln351Glu Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Gln383Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome

Predictors split 1033

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 1033

CDH1 p.Ala289Val Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Ala408Val Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Ala617Thr Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Arg124Cys Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Arg124His Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Arg224Cys Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Arg224His Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Arg335Gln Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Arg54Gly Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Arg74Gln Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Arg90Gln Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Asn622Ser Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Asn674Tyr Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Asp244Gly Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Asp433Asn Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Asp433Gly Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Asp498Ala Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Asp72Asn Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Asp805Asn Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Glu167Lys Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Glu388Lys Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Glu58Val Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Glu880Lys Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Gly31Val Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Gly49Arg Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Gly62Ser Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Gly879Ser Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Leu21Ile Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Leu630Val Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Leu721Val Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Lys182Asn Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Pro30Thr Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Pro42Leu Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Pro799Arg Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Ser270Ala Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr115Met Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr340Ala Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr340Met Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr379Met Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr38Lys Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr38Met Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr38Pro Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr470Ile Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr522Ile Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Thr562Ala Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Val202Ile Benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Val202Leu Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Val242Ile Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Val392Ile Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Val41Leu Uncertain significance Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Val473Ile Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Val55Gly Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Val685Met Likely benign Expert panel
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Ala226Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala234Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala241Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala299Thr Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala359Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala361Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala401Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala408Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala408Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala408Pro Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala411Thr Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala439Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala483Val Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala530Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala563Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala563Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala563Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala592Asp Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala592Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala617Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala617Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala634Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala709Ser Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala843Asp Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Ala843Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Ala873Gly Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Arg108Ser Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Arg209Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg321Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg43Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg492Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg50Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg50Gly Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Arg545Gly Uncertain significance Multiple submitters
hereditary breast carcinoma
CDH1 p.Arg545Pro Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Arg545Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg605Gly Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Arg63Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg6His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg732Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg734Ile Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg734Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg734Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg74Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg74Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg74Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg774Gly Uncertain significance Multiple submitters
CDH1-related diffuse gastric and lobular breast cancer syndrome
CDH1 p.Arg784His Uncertain significance Multiple submitters
CDH1-related disorder
CDH1 p.Arg796Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Arg87Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn174Ile Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asn258Ser Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asn258Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn297Ser Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asn320Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn322Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn371Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn405Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn417His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn417Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn481Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn558Ile Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn570His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn591His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn591Ser Uncertain significance Multiple submitters
hereditary breast carcinoma
CDH1 p.Asn622His Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asn643His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn751Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn803Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asn809Ser Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asn849Asp Uncertain significance Multiple submitters
hereditary breast carcinoma
CDH1 p.Asp155Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp183Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp198Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp308His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp419Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp433Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp476Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp479Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp528Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp538Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp549Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp644Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp644His Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp746Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp746Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp747Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp786Asn Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp805Gly Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp805His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp812Gly Uncertain significance Multiple submitters
blepharocheilodontic syndrome 1
CDH1 p.Asp854Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp856Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp856Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp858Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
CDH1 p.Asp858Gly Uncertain significance Multiple submitters
hereditary diffuse gastric adenocarcinoma
CDH1 p.Asp860Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome

All CDH1 variants

Pathogenic 403

Showing the top 300 by review status; the full set is in the sitemap.

c.1137+1del Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1137+1G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1565+1G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1565+1G>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1565+1G>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1565+2dup Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1711+1G>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.48+1G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.49-2A>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.532-1G>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.687+1G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.832+1G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.832+1G>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.833-2A>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala530fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala546fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg154fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg335Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg492fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg598Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg63Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg732Gln Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Arg74Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg800fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Asn174fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Asn369fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Asn390fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Asn481fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Asn531fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Asp538fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Cys163Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Cys688_Glu689delinsTer Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln177Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln351Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln383Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln511Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln641Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln677fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln699Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln765Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln771Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln95Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu24Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu261Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu265Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu26Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu336= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu494Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu497fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu648Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu702Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu758Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu763Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu836Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly169fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly239Arg Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly354_Leu355insTer Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly502fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly579fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly693fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly715fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly759fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly775fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.His121fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.His128fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.His632fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ile415fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ile594fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ile640fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ile650fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ile651fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ile665fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Leu452fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Leu583fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Leu667fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Lys113Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Lys153Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Lys314Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Met1Arg Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Met1Ile Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Met1Lys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Met1Thr Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Met1Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Phe810fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Pro147fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Pro219fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Pro42fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Pro826fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ser236Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ser337Phefs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ser70fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ser9Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Thr106fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Thr199fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Thr379= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Thr438fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Thr470fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Thr560Arg Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Trp156Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Trp20Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Trp4Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Trp638Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Tyr341Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Tyr68fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Tyr755Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Val345fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Val362fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Val464fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Val487fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Val701fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.49-2A>C Multiple submitters hereditary neoplastic syndrome
p.Ala617fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Arg108fs Multiple submitters hereditary neoplastic syndrome
p.Arg734Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asn315fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asn458fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asn536fs Multiple submitters hereditary neoplastic syndrome
p.Asn570fs Multiple submitters hereditary neoplastic syndrome
p.Asp528fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asp786delinsGlnProSerTrpTer Multiple submitters hereditary neoplastic syndrome
p.Cys28Ter Multiple submitters hereditary neoplastic syndrome
p.Gln129Ter Multiple submitters hereditary breast carcinoma
p.Gln16Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gln195Ter Multiple submitters hereditary breast carcinoma
p.Gln23Ter Multiple submitters hereditary neoplastic syndrome
p.Gln346Ter Multiple submitters hereditary neoplastic syndrome
p.Gln448fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gln519Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gln610Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gln647Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Glu210Ter Multiple submitters hereditary neoplastic syndrome
p.Glu534Ter Multiple submitters hereditary neoplastic syndrome
p.Glu551Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gly186fs Multiple submitters hereditary neoplastic syndrome
p.Gly212Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gly278Arg Multiple submitters hereditary neoplastic syndrome
p.Gly661fs Multiple submitters hereditary neoplastic syndrome
p.Gly759Ter Multiple submitters hereditary neoplastic syndrome
p.Gly808Ter Multiple submitters CDH1-related diffuse gastric and lobular breast cancer syndrome
p.His233fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ile614fs Multiple submitters hereditary neoplastic syndrome
p.Leu11fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Leu15fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Leu466fs Multiple submitters hereditary neoplastic syndrome
p.Leu705fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Leu741fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Lys109fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Lys179fs Multiple submitters hereditary neoplastic syndrome
p.Lys397Ter Multiple submitters hereditary neoplastic syndrome
p.Phe142fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Phe626fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Pro201fs Multiple submitters hereditary neoplastic syndrome
p.Trp103Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Trp526Ter Multiple submitters hereditary neoplastic syndrome
p.Trp532Ter Multiple submitters hereditary neoplastic syndrome
p.Tyr190Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Tyr296fs Multiple submitters hereditary neoplastic syndrome
p.Tyr523Ter Multiple submitters hereditary neoplastic syndrome
p.Tyr561Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Tyr754Ter Multiple submitters hereditary neoplastic syndrome
p.Val157fs Multiple submitters hereditary neoplastic syndrome
p.Val365fs Multiple submitters hereditary neoplastic syndrome
c.(1008+1_1009-1 Single submitter hereditary diffuse gastric adenocarcinoma
c.1135_1137+5delinsTTAGA Single submitter hereditary diffuse gastric adenocarcinoma
c.(1320+1_1321-1 Single submitter hereditary diffuse gastric adenocarcinoma
c.(1565+1_1566-1 Single submitter hereditary diffuse gastric adenocarcinoma
c.1565+3_1565+4insTT Single submitter hereditary diffuse gastric adenocarcinoma
c.(163+1_164-1 Single submitter hereditary diffuse gastric adenocarcinoma
c.1935_1936+9del Single submitter hereditary diffuse gastric adenocarcinoma
c.2164+2T>A Single submitter hereditary diffuse gastric adenocarcinoma
c.2164+6_2439+966del Single submitter hereditary diffuse gastric adenocarcinoma
c.2165-2A>C Single submitter hereditary diffuse gastric adenocarcinoma
c.2440_2649del Single submitter
c.(387+1_388-1 Single submitter hereditary diffuse gastric adenocarcinoma
c.388-?_*2042+?del Single submitter hereditary diffuse gastric adenocarcinoma
c.48+2T>C Single submitter hereditary diffuse gastric adenocarcinoma
c.49-3_49-1del Single submitter hereditary neoplastic syndrome
c.51_163+2del Single submitter
c.687+1_687+2del Single submitter hereditary neoplastic syndrome
c.688-1G>C Single submitter hereditary diffuse gastric adenocarcinoma
c.691_697delTTCTCTC Single submitter hereditary neoplastic syndrome
c.757_832+3del Single submitter hereditary neoplastic syndrome
p.Ala137fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala348fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala408fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala439fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala563fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala634fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala636fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala691fs Single submitter hereditary neoplastic syndrome
p.Ala719fs Single submitter hereditary neoplastic syndrome
p.Ala824fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Arg335fs Single submitter hereditary neoplastic syndrome
p.Arg74fs Single submitter hereditary neoplastic syndrome
p.Arg784fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Arg87fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Arg90fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asn144fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asn166fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asn240fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asn258fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asn294fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asn432fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asn643fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asn666fs Single submitter hereditary neoplastic syndrome
p.Asn751fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asp104delinsValHisArgSerThrLysAspSerLeuPhePheProArgHisProIleGlnSerGlyHisArgTrpCysAspTyrSerGlnLysAlaSerThrValSerTer Single submitter hereditary diffuse gastric adenocarcinoma
p.Asp155fs Single submitter hereditary neoplastic syndrome
p.Asp221fs Single submitter endometrial carcinoma
p.Asp349fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asp367fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asp498fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asp569fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asp766fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Asp777fs Single submitter hereditary neoplastic syndrome
p.Cys163fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Cys22fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Cys22Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Cys28fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Cys603fs Single submitter hereditary breast carcinoma
p.Cys686fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Cys688delinsHisLeuArgGlyGlnArgValTer Single submitter
p.Cys695Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln129fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln152_Lys153delinsHisTer Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln152fs Single submitter hereditary neoplastic syndrome
p.Gln16fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln255Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln307Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln422fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln422Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln448Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln449_Tyr450insTer Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln449fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln503Ter Single submitter hereditary neoplastic syndrome
p.Gln641fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln64Ter Single submitter
p.Gln673fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln677_Val678insTer Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln706fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln706Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln765fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln771fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu185fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu185Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu208delinsAspTyrTer Single submitter hereditary neoplastic syndrome
p.Glu218fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu243Ter Single submitter hereditary neoplastic syndrome
p.Glu273Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu353fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu386Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu388Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu410Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu463Ter Single submitter hereditary neoplastic syndrome
p.Glu47fs Single submitter hereditary neoplastic syndrome
p.Glu47Ter Single submitter hereditary neoplastic syndrome
p.Glu490fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu497Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu534fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu547fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu554Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu596Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu762Ter Single submitter hereditary neoplastic syndrome
p.Gly196Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly324fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly324Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly382fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly421fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly421Ter Single submitter hereditary neoplastic syndrome
p.Gly434fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly716fs Single submitter hereditary breast carcinoma
p.His29fs Single submitter hereditary diffuse gastric adenocarcinoma
p.His453fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Ile158fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Ile161fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Ile248fs Single submitter hereditary neoplastic syndrome
p.Ile435_Leu436insTer Single submitter hereditary neoplastic syndrome
p.Ile521fs Single submitter hereditary neoplastic syndrome
p.Ile566fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Ile722fs Single submitter hereditary breast carcinoma
p.Ile83fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu139fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu140fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu355fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu355Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu46fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu564fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu630fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu652fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu658fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu728Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu729fs Single submitter hereditary neoplastic syndrome
p.Leu731fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu741Ter Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu769Ter Single submitter hereditary neoplastic syndrome
p.Leu99fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Lys153fs Single submitter hereditary neoplastic syndrome
p.Lys168fs Single submitter hereditary neoplastic syndrome
p.Lys173Ter Single submitter hereditary neoplastic syndrome
p.Lys215fs Single submitter hereditary diffuse gastric adenocarcinoma

Pathogenic/Likely pathogenic 34

c.1008+1G>A Multiple submitters hereditary neoplastic syndrome
c.1008+1G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1009-1G>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1553_1565+39del Multiple submitters hereditary neoplastic syndrome
c.1565+2_1565+3insTT Multiple submitters hereditary neoplastic syndrome
c.163+1G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1711+1dup Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2164+1G>T Multiple submitters hereditary neoplastic syndrome
c.2165-1G>A Multiple submitters hereditary neoplastic syndrome
c.2165-1G>T Multiple submitters hereditary neoplastic syndrome
c.2165-2A>G Multiple submitters hereditary neoplastic syndrome
c.48+1G>C Multiple submitters hereditary neoplastic syndrome
c.49-1G>A Multiple submitters hereditary neoplastic syndrome
c.49-1G>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.687+1G>C Multiple submitters hereditary neoplastic syndrome
c.833-1G>A Multiple submitters hereditary neoplastic syndrome
p.Ala634Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn405fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asp514_Thr522delinsValTer Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Glu35Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Glu58Ter Multiple submitters hereditary neoplastic syndrome
p.Glu806Ter Multiple submitters hereditary neoplastic syndrome
p.Met1Leu Multiple submitters hereditary neoplastic syndrome
p.Phe423fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Pro127fs Multiple submitters hereditary neoplastic syndrome
p.Thr360fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Thr457fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Thr599fs Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Tyr107Ter Multiple submitters blepharocheilodontic syndrome 1
p.Tyr228Ter Multiple submitters hereditary neoplastic syndrome
p.Tyr642Ter Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Tyr827Ter Multiple submitters hereditary neoplastic syndrome
p.Val82fs Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1320+1G>T No assertion criteria

Likely pathogenic 107

c.1008+2T>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1137+2T>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1320+1G>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1565+1del Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1565+5G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1711+1G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1711+2_1711+7del Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.2165-1G>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.2296-1G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.2296-2A>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.2439+5_2439+8del Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.2440-2A>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.531+1G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.833-9C>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg796fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu336Asp Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu353Lys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Lys816Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Thr568Arg Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Tyr835Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.152_163+11del Multiple submitters hereditary diffuse gastric adenocarcinoma
c.163+1G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.164-2A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1936+1G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1936+5G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2164+1G>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2295+1G>A Multiple submitters hereditary neoplastic syndrome
c.2295+1G>C Multiple submitters hereditary neoplastic syndrome
c.2439+2T>C Multiple submitters hereditary breast carcinoma
c.531+1G>C Multiple submitters hereditary neoplastic syndrome
c.531+1G>T Multiple submitters hereditary neoplastic syndrome
c.687+1G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gly571Ser Multiple submitters hereditary neoplastic syndrome ⚠
c.1008+2_1008+4del Single submitter hereditary diffuse gastric adenocarcinoma
c.1008+2T>G Single submitter hereditary diffuse gastric adenocarcinoma
c.1128_1137+1delinsGGAGT Single submitter hereditary diffuse gastric adenocarcinoma
c.1137+2T>A Single submitter hereditary diffuse gastric adenocarcinoma
c.1138-1G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.1138-2A>G Single submitter hereditary diffuse gastric adenocarcinoma
c.1298_1320+12del Single submitter hereditary diffuse gastric adenocarcinoma
c.1321-1G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.1321-1G>C Single submitter hereditary diffuse gastric adenocarcinoma
c.1321-1G>T Single submitter hereditary diffuse gastric adenocarcinoma
c.1321-6_1324del Single submitter hereditary diffuse gastric adenocarcinoma
c.1321-9_1331dup Single submitter hereditary diffuse gastric adenocarcinoma
c.139_163+18del Single submitter hereditary diffuse gastric adenocarcinoma
c.147_163+6del Single submitter hereditary diffuse gastric adenocarcinoma
c.1566-1del Single submitter hereditary diffuse gastric adenocarcinoma
c.163+1G>C Single submitter hereditary diffuse gastric adenocarcinoma
c.163+2T>C Single submitter hereditary diffuse gastric adenocarcinoma
c.164-21_288del Single submitter hereditary diffuse gastric adenocarcinoma
c.1711+1G>T Single submitter hereditary diffuse gastric adenocarcinoma
c.1936+2T>C Single submitter hereditary neoplastic syndrome
c.2164_2439del Single submitter hereditary diffuse gastric adenocarcinoma
c.2164+1_2164+2del Single submitter hereditary diffuse gastric adenocarcinoma
c.2164+1del Single submitter hereditary diffuse gastric adenocarcinoma
c.2164+1G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.2439+1G>T Single submitter hereditary diffuse gastric adenocarcinoma
c.2440-396_*223del Single submitter hereditary diffuse gastric adenocarcinoma
c.388-1G>T Single submitter hereditary diffuse gastric adenocarcinoma
c.388-6_393del Single submitter hereditary diffuse gastric adenocarcinoma
c.48+2_48+6delinsCACCT Single submitter hereditary diffuse gastric adenocarcinoma
c.49-1G>T Single submitter hereditary diffuse gastric adenocarcinoma
c.531+1del Single submitter hereditary diffuse gastric adenocarcinoma
c.531+2T>C Single submitter hereditary diffuse gastric adenocarcinoma
c.532-1del Single submitter hereditary diffuse gastric adenocarcinoma
c.532-2A>C Single submitter hereditary diffuse gastric adenocarcinoma
c.532-2A>G Single submitter hereditary diffuse gastric adenocarcinoma
c.532-2A>T Single submitter
c.812_833-564del Single submitter hereditary diffuse gastric adenocarcinoma
c.833-275_856del Single submitter hereditary diffuse gastric adenocarcinoma
c.833-2A>C Single submitter hereditary diffuse gastric adenocarcinoma
c.833-476_1138-463del Single submitter hereditary diffuse gastric adenocarcinoma
c.833-8_836del Single submitter hereditary diffuse gastric adenocarcinoma
p.Arg732= Single submitter hereditary neoplastic syndrome
p.Asn315Ser Single submitter hereditary neoplastic syndrome ⚠
p.Asn458del Single submitter blepharocheilodontic syndrome 1
p.Asp476fs Single submitter hereditary neoplastic syndrome
p.Asp812fs Single submitter hereditary neoplastic syndrome
p.Asp821fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Cys688fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu210fs Single submitter hereditary breast carcinoma
p.Glu758Lys Single submitter hereditary neoplastic syndrome
p.Glu841fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly661_Asp662insTer Single submitter hereditary diffuse gastric adenocarcinoma
p.Ile300fs Single submitter hereditary breast ovarian cancer syndrome
p.Ile811fs Single submitter hereditary neoplastic syndrome
p.Leu815fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu831fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Lys440Asn Single submitter hereditary breast carcinoma ⚠
p.Lys440fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Phe189fs Single submitter hereditary neoplastic syndrome
p.Pro277= Single submitter hereditary neoplastic syndrome
p.Pro625fs Single submitter hereditary breast ovarian cancer syndrome
p.Ser5fs Single submitter
p.Thr193fs Single submitter hereditary breast carcinoma
p.Thr342fs Single submitter hereditary diffuse gastric adenocarcinoma
p.Thr823fs Single submitter hereditary breast carcinoma
p.Trp156Cys Single submitter
p.Tyr561fs Single submitter diffuse midline glioma, H3 K27-altered
p.Val252fs Single submitter hereditary breast carcinoma
p.Val456fs Single submitter hereditary breast carcinoma
p.Arg151fs No assertion criteria breast carcinoma
p.Asn256Lys No assertion criteria Cleft lip with or without cleft palate
p.Asn589Ile No assertion criteria Cleft lip with or without cleft palate
p.Asn809fs No assertion criteria Cleft lip with or without cleft palate
p.Gln677Ter No assertion criteria

Conflicting classifications of pathogenicity 455

Showing the top 300 by review status; the full set is in the sitemap.

c.1008+11_1008+19del Single submitter hereditary neoplastic syndrome
c.1008+4del Single submitter hereditary neoplastic syndrome
c.1008+8G>T Single submitter hereditary diffuse gastric adenocarcinoma
c.1009-14C>T Single submitter ovarian cancer
c.1009-32G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.1137+6T>G Single submitter hereditary neoplastic syndrome
c.1137+9A>G Single submitter hereditary neoplastic syndrome
c.1137+9A>T Single submitter hereditary diffuse gastric adenocarcinoma
c.1138-10T>C Single submitter hereditary neoplastic syndrome
c.1138-13C>G Single submitter hereditary neoplastic syndrome
c.1138-15C>G Single submitter endometrial carcinoma
c.1320+1G>A Single submitter hereditary diffuse gastric adenocarcinoma ⚠
c.1321-3T>C Single submitter hereditary neoplastic syndrome
c.1321-88C>T Single submitter hereditary diffuse gastric adenocarcinoma
c.1565+13A>G Single submitter hereditary breast carcinoma
c.1565+3A>G Single submitter hereditary neoplastic syndrome
c.1565+9G>C Single submitter hereditary diffuse gastric adenocarcinoma
c.1566-15C>A Single submitter hereditary neoplastic syndrome
c.1566-4T>C Single submitter hereditary neoplastic syndrome
c.1566-7C>G Single submitter hereditary neoplastic syndrome
c.1566-7del Single submitter hereditary diffuse gastric adenocarcinoma
c.1566-8C>G Single submitter hereditary neoplastic syndrome
c.1566-9C>T Single submitter hereditary diffuse gastric adenocarcinoma
c.163+8C>T Single submitter hereditary neoplastic syndrome
c.164-15A>T Single submitter hereditary neoplastic syndrome
c.164-1G>A Single submitter hereditary diffuse gastric adenocarcinoma ⚠
c.164-5T>C Single submitter hereditary neoplastic syndrome
c.1711+6G>T Single submitter hereditary neoplastic syndrome
c.1711+7G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.1712-14G>A Single submitter ovarian cancer
c.1712-3T>C Single submitter hereditary neoplastic syndrome
c.1712-5C>A Single submitter hereditary diffuse gastric adenocarcinoma
c.1712-8T>C Single submitter hereditary neoplastic syndrome
c.1936+3G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.1936+4G>A Single submitter hereditary neoplastic syndrome
c.1937-11_1937-8dup Single submitter hereditary neoplastic syndrome
c.1937-25C>A Single submitter hereditary diffuse gastric adenocarcinoma
c.1937-29T>C Single submitter hereditary diffuse gastric adenocarcinoma
c.1937-37C>G Single submitter hereditary diffuse gastric adenocarcinoma
c.1937-4C>T Single submitter hereditary neoplastic syndrome
c.1937-6C>T Single submitter Breast and/or ovarian cancer
c.1937-9T>A Single submitter hereditary diffuse gastric adenocarcinoma
c.2164+3_2164+6del Single submitter hereditary diffuse gastric adenocarcinoma
c.2164+3A>G Single submitter hereditary neoplastic syndrome
c.2164+5G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.2164+7C>T Single submitter hereditary neoplastic syndrome
c.2165-15C>A Single submitter hereditary neoplastic syndrome
c.2165-17C>T Single submitter hereditary neoplastic syndrome
c.2165-19G>T Single submitter hereditary neoplastic syndrome
c.2165-5C>T Single submitter hereditary neoplastic syndrome
c.2165-7A>G Single submitter hereditary diffuse gastric adenocarcinoma
c.2165-8C>A Single submitter hereditary neoplastic syndrome
c.2295+3G>A Single submitter hereditary neoplastic syndrome
c.2295+45C>T Single submitter hereditary diffuse gastric adenocarcinoma
c.2295+46G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.2295+4G>A Single submitter hereditary neoplastic syndrome
c.2296-11T>A Single submitter hereditary neoplastic syndrome
c.2296-12T>C Single submitter hereditary neoplastic syndrome
c.2296-14T>C Single submitter hereditary neoplastic syndrome
c.2296-3A>G Single submitter hereditary diffuse gastric adenocarcinoma
c.2296-3A>T Single submitter hereditary neoplastic syndrome
c.2296-4A>G Single submitter hereditary neoplastic syndrome
c.2440-12CTT[2] Single submitter hereditary neoplastic syndrome
c.2440-143G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.2440-18_2440-10del Single submitter hereditary diffuse gastric adenocarcinoma
c.2440-3T>C Single submitter hereditary diffuse gastric adenocarcinoma
c.2440-4T>G Single submitter hereditary neoplastic syndrome
c.388-14T>G Single submitter hereditary neoplastic syndrome
c.388-21C>A Single submitter hereditary diffuse gastric adenocarcinoma
c.388-3T>C Single submitter hereditary neoplastic syndrome
c.388-4T>C Single submitter hereditary breast carcinoma
c.388-8C>G Single submitter hereditary neoplastic syndrome
c.388-8C>T Single submitter hereditary neoplastic syndrome
c.48+5_48+6delinsAT Single submitter hereditary neoplastic syndrome
c.48+5_48+6delinsGT Single submitter hereditary diffuse gastric adenocarcinoma
c.48+5_48+6delinsTT Single submitter hereditary neoplastic syndrome
c.48+6_48+7delinsTG Single submitter hereditary neoplastic syndrome
c.48+6_48+8delinsTCA Single submitter hereditary diffuse gastric adenocarcinoma
c.49-16C>G Single submitter hereditary neoplastic syndrome
c.49-19T>C Single submitter hereditary neoplastic syndrome
c.49-4C>A Single submitter hereditary neoplastic syndrome
c.49-4C>T Single submitter hereditary neoplastic syndrome
c.49-5C>T Single submitter hereditary neoplastic syndrome
c.531+17T>C Single submitter hereditary neoplastic syndrome
c.531+3A>G Single submitter hereditary neoplastic syndrome
c.531+4G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.531+9A>G Single submitter hereditary diffuse gastric adenocarcinoma
c.532-8G>C Single submitter hereditary neoplastic syndrome
c.687+92T>A Single submitter hereditary diffuse gastric adenocarcinoma
c.688-20C>A Single submitter hereditary diffuse gastric adenocarcinoma
c.832+3A>G Single submitter hereditary neoplastic syndrome
c.832+4T>A Single submitter hereditary neoplastic syndrome
c.832+4T>C Single submitter hereditary diffuse gastric adenocarcinoma
c.832+5A>G Single submitter hereditary neoplastic syndrome
c.832+6T>C Single submitter hereditary diffuse gastric adenocarcinoma
c.832+6T>G Single submitter hereditary diffuse gastric adenocarcinoma
c.833-34T>C Single submitter hereditary diffuse gastric adenocarcinoma
c.833-3C>T Single submitter hereditary neoplastic syndrome
c.833-4C>A Single submitter hereditary neoplastic syndrome
c.-18C>T Single submitter hereditary neoplastic syndrome
c.-20C>T Single submitter hereditary neoplastic syndrome
c.-29C>G Single submitter hereditary diffuse gastric adenocarcinoma
c.-2C>T Single submitter hereditary neoplastic syndrome
c.-41C>A Single submitter hereditary diffuse gastric adenocarcinoma
c.-63C>A Single submitter hereditary diffuse gastric adenocarcinoma
c.-6C>T Single submitter hereditary neoplastic syndrome
c.-8G>C Single submitter hereditary neoplastic syndrome
c.*14G>C Single submitter hereditary neoplastic syndrome
c.*16C>T Single submitter hereditary neoplastic syndrome
c.*29C>A Single submitter hereditary diffuse gastric adenocarcinoma
c.*3G>C Single submitter hereditary neoplastic syndrome
c.*7C>T Single submitter hereditary neoplastic syndrome
c.*8G>A Single submitter CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala102Ser Single submitter hereditary neoplastic syndrome ⚠
p.Ala10Glu Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Ala10Thr Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Ala130Asp Single submitter hereditary neoplastic syndrome ⚠
p.Ala137Pro Single submitter hereditary neoplastic syndrome ⚠
p.Ala137Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala241Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala275Val Single submitter hereditary neoplastic syndrome ⚠
p.Ala289Thr Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Ala299Gly Single submitter CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Ala301Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala301Val Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Ala361= Single submitter hereditary neoplastic syndrome
p.Ala389Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala401Asp Single submitter CDH1-related disorder ⚠
p.Ala401Val Single submitter hereditary neoplastic syndrome ⚠
p.Ala439Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala446Asp Single submitter hereditary neoplastic syndrome ⚠
p.Ala634Ser Single submitter hereditary neoplastic syndrome ⚠
p.Ala636Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala636Val Single submitter hereditary neoplastic syndrome ⚠
p.Ala67Asp Single submitter hereditary neoplastic syndrome ⚠
p.Ala67Gly Single submitter hereditary neoplastic syndrome ⚠
p.Ala67Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala691Thr Single submitter ovarian cancer ⚠
p.Ala691Val Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Ala692Thr Single submitter hereditary breast carcinoma ⚠
p.Ala698Pro Single submitter hereditary neoplastic syndrome ⚠
p.Ala735= Single submitter Breast and/or ovarian cancer
p.Ala735Glu Single submitter hereditary neoplastic syndrome ⚠
p.Ala735Gly Single submitter hereditary neoplastic syndrome ⚠
p.Arg108Gly Single submitter hereditary breast carcinoma ⚠
p.Arg124Pro Single submitter hereditary neoplastic syndrome ⚠
p.Arg154= Single submitter hereditary neoplastic syndrome
p.Arg224Leu Single submitter hereditary neoplastic syndrome ⚠
p.Arg44Leu Single submitter hereditary neoplastic syndrome ⚠
p.Arg492Thr Single submitter hereditary neoplastic syndrome ⚠
p.Arg50His Single submitter hereditary neoplastic syndrome ⚠
p.Arg524Gly Single submitter hereditary neoplastic syndrome ⚠
p.Arg524Trp Single submitter hereditary breast carcinoma ⚠
p.Arg545= Single submitter hereditary neoplastic syndrome
p.Arg545Gln Single submitter hereditary neoplastic syndrome ⚠
p.Arg545Leu Single submitter hereditary neoplastic syndrome ⚠
p.Arg598Gln Single submitter hereditary neoplastic syndrome ⚠
p.Arg732Trp Single submitter hereditary neoplastic syndrome ⚠
p.Arg749Gln Single submitter hereditary neoplastic syndrome ⚠
p.Arg774= Single submitter hereditary neoplastic syndrome
p.Arg779Trp Single submitter hereditary neoplastic syndrome ⚠
p.Arg796Gln Single submitter hereditary breast carcinoma ⚠
p.Arg868Cys Single submitter hereditary neoplastic syndrome ⚠
p.Arg868His Single submitter hereditary breast carcinoma ⚠
p.Arg90Trp Single submitter hereditary neoplastic syndrome ⚠
p.Asn117Ser Single submitter hereditary neoplastic syndrome ⚠
p.Asn144Ser Single submitter hereditary neoplastic syndrome ⚠
p.Asn238His Single submitter hereditary neoplastic syndrome ⚠
p.Asn240Ser Single submitter CDH1-related disorder ⚠
p.Asn376Thr Single submitter hereditary neoplastic syndrome ⚠
p.Asn387= Single submitter hereditary neoplastic syndrome
p.Asn387Ser Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Asn390Asp Single submitter hereditary neoplastic syndrome ⚠
p.Asn390Ser Single submitter hereditary neoplastic syndrome ⚠
p.Asn405Asp Single submitter hereditary neoplastic syndrome ⚠
p.Asn405Ile Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Asn405Lys Single submitter hereditary neoplastic syndrome ⚠
p.Asn405Ser Single submitter CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asn417Ser Single submitter hereditary breast carcinoma ⚠
p.Asn432Ser Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Asn531Ser Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Asn558Lys Single submitter hereditary neoplastic syndrome ⚠
p.Asn570Asp Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Asn589= Single submitter hereditary neoplastic syndrome
p.Asn591= Single submitter hereditary neoplastic syndrome
p.Asn643= Single submitter Breast and/or ovarian cancer
p.Asn643Asp Single submitter hereditary breast carcinoma ⚠
p.Asn666His Single submitter hereditary breast carcinoma ⚠
p.Asn666Ser Single submitter hereditary neoplastic syndrome ⚠
p.Asn751Lys Single submitter hereditary neoplastic syndrome ⚠
p.Asn863= Single submitter Breast and/or ovarian cancer
p.Asn867Ser Single submitter hereditary neoplastic syndrome ⚠
p.Asp221Gly Single submitter blepharocheilodontic syndrome 1 ⚠
p.Asp254Asn Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Asp291Asn Single submitter hereditary breast carcinoma ⚠
p.Asp308= Single submitter hereditary neoplastic syndrome
p.Asp308Glu Single submitter hereditary neoplastic syndrome ⚠
p.Asp313Glu Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Asp313His Single submitter hereditary neoplastic syndrome ⚠
p.Asp313Tyr Single submitter hereditary neoplastic syndrome ⚠
p.Asp33Gly Single submitter hereditary neoplastic syndrome ⚠
p.Asp400Asn Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Asp419Asn Single submitter hereditary neoplastic syndrome ⚠
p.Asp498Asn Single submitter hereditary neoplastic syndrome ⚠
p.Asp538Asn Single submitter hereditary neoplastic syndrome ⚠
p.Asp59Glu Single submitter CDH1-related disorder ⚠
p.Asp644Asn Single submitter hereditary breast carcinoma ⚠
p.Asp662Gly Single submitter hereditary neoplastic syndrome ⚠
p.Asp676Asn Single submitter hereditary neoplastic syndrome ⚠
p.Asp750Gly Single submitter hereditary neoplastic syndrome ⚠
p.Asp882Asn Single submitter hereditary breast carcinoma ⚠
p.Cys163Ser Single submitter blepharocheilodontic syndrome 1 ⚠
p.Gln129= Single submitter hereditary neoplastic syndrome
p.Gln16= Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln16His Single submitter hereditary neoplastic syndrome ⚠
p.Gln16Lys Single submitter hereditary neoplastic syndrome ⚠
p.Gln264Arg Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Gln346Glu Single submitter hereditary neoplastic syndrome ⚠
p.Gln351Arg Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Gln383His Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Gln422Arg Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Gln503His Single submitter hereditary neoplastic syndrome ⚠
p.Gln511His Single submitter hereditary neoplastic syndrome ⚠
p.Gln673Lys Single submitter hereditary breast carcinoma ⚠
p.Gln765= Single submitter hereditary neoplastic syndrome
p.Gln95Glu Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Glu218Lys Single submitter hereditary neoplastic syndrome ⚠
p.Glu261Lys Single submitter hereditary neoplastic syndrome ⚠
p.Glu265Val Single submitter hereditary neoplastic syndrome ⚠
p.Glu310Gly Single submitter hereditary neoplastic syndrome ⚠
p.Glu388Gln Single submitter hereditary neoplastic syndrome ⚠
p.Glu445Ala Single submitter hereditary neoplastic syndrome ⚠
p.Glu490Lys Single submitter hereditary neoplastic syndrome ⚠
p.Glu504= Single submitter hereditary neoplastic syndrome
p.Glu504Lys Single submitter hereditary neoplastic syndrome ⚠
p.Glu512Asp Single submitter hereditary neoplastic syndrome ⚠
p.Glu58Lys Single submitter hereditary neoplastic syndrome ⚠
p.Glu648Asp Single submitter hereditary neoplastic syndrome ⚠
p.Glu745Asp Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Glu757Lys Single submitter hereditary neoplastic syndrome ⚠
p.Glu758Gly Single submitter hereditary neoplastic syndrome ⚠
p.Glu762= Single submitter hereditary neoplastic syndrome
p.Glu781= Single submitter hereditary neoplastic syndrome
p.Glu852Ala Single submitter hereditary neoplastic syndrome ⚠
p.Glu880= Single submitter hereditary neoplastic syndrome
p.Gly120Trp Single submitter hereditary neoplastic syndrome ⚠
p.Gly134Arg Single submitter hereditary neoplastic syndrome ⚠
p.Gly186Val Single submitter hereditary neoplastic syndrome ⚠
p.Gly278= Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly31= Single submitter hereditary neoplastic syndrome
p.Gly420Asp Single submitter hereditary neoplastic syndrome ⚠
p.Gly421Arg Single submitter hereditary neoplastic syndrome ⚠
p.Gly421del Single submitter hereditary neoplastic syndrome
p.Gly49= Single submitter hereditary neoplastic syndrome
p.Gly633Arg Single submitter hereditary neoplastic syndrome ⚠
p.Gly759Ala Single submitter hereditary neoplastic syndrome ⚠
p.Gly761del Single submitter CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly78Val Single submitter hereditary neoplastic syndrome ⚠
p.Gly839Ser Single submitter hereditary neoplastic syndrome ⚠
p.His121Arg Single submitter hereditary neoplastic syndrome ⚠
p.His121Asn Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.His122Tyr Single submitter hereditary neoplastic syndrome ⚠
p.His123Gln Single submitter hereditary neoplastic syndrome ⚠
p.His128Arg Single submitter hereditary neoplastic syndrome ⚠
p.His233= Single submitter hereditary neoplastic syndrome
p.His555Asp Single submitter hereditary neoplastic syndrome ⚠
p.His632Arg Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.His773Arg Single submitter hereditary neoplastic syndrome ⚠
p.His92Gln Single submitter hereditary neoplastic syndrome ⚠
p.His97Asp Single submitter hereditary neoplastic syndrome ⚠
p.Ile135Asn Single submitter hereditary neoplastic syndrome ⚠
p.Ile319= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ile319Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile363Leu Single submitter hereditary neoplastic syndrome ⚠
p.Ile363Val Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Ile374= Single submitter hereditary neoplastic syndrome
p.Ile393Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile415Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ile415Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile435Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile451Leu Single submitter hereditary neoplastic syndrome ⚠
p.Ile451Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile485Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ile566Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ile566Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile594Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile614Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile615Phe Single submitter hereditary neoplastic syndrome ⚠
p.Ile615Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ile615Val Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Ile651Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ile651Val Single submitter CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Ile83= Single submitter hereditary neoplastic syndrome
p.Ile83Val Single submitter hereditary diffuse gastric adenocarcinoma ⚠
p.Ile96Thr Single submitter hereditary neoplastic syndrome ⚠
p.Leu11Met Single submitter hereditary neoplastic syndrome ⚠
p.Leu12= Single submitter hereditary breast carcinoma
p.Leu140= Single submitter hereditary neoplastic syndrome
p.Leu15del Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu249Phe Single submitter hereditary neoplastic syndrome ⚠

Benign 174

c.1137+86T>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1937-13T>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1937-423G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.2164+17dup Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.2295+166C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.2439+22C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.387+5G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.48+5C>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.48+6C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.531+10G>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.833-16C>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.-71C>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*1120T>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*1176T>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*1662G>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*1691G>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*1835T>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*1873G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*410A>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*54C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*589C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*621C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*774A>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.*988G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala102Thr Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala298Thr Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala408Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Ala592Thr Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala617Thr Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Ala692= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg108= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg224His Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Arg63Gln Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg779Gln Expert panel hereditary diffuse gastric adenocarcinoma
p.Arg800His Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Asn751= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Asp433Gly Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asp805Asn Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Glu388Lys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Glu702Lys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu880Lys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Gly274Ser Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly878= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.His632= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ile393Asn Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ile96Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Leu311= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Leu630Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Lys182Asn Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Pro30Thr Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Ser270Ala Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Thr115= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Thr340Ala Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Thr470Ile Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Thr522Ile Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Tyr523Cys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Val202Ile Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Val832Met Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1008+47T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1320+178A>G Multiple submitters
c.1320+186T>G Multiple submitters
c.1320+45G>C Multiple submitters
c.1321-36C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1566-80C>G Multiple submitters
c.1711+47G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1712-52G>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1937-266C>G Multiple submitters
c.1937-302G>A Multiple submitters
c.2296-243T>C Multiple submitters
c.2439+162C>T Multiple submitters
c.2439+163T>C Multiple submitters
c.2439+52G>A Multiple submitters
c.48+181G>C Multiple submitters blepharocheilodontic syndrome 1
c.48+62_48+63insCGTGCCCCAGCCC Multiple submitters
c.687+144G>A Multiple submitters
c.687+66A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1008+131_1008+132insA Single submitter
c.1008+132_1008+133insA Single submitter
c.1320+205C>T Single submitter
c.1320+35C>T Single submitter hereditary diffuse gastric adenocarcinoma
c.1565+175C>T Single submitter
c.1565+242A>G Single submitter
c.1566-218A>T Single submitter
c.164-14627G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.1711+209G>A Single submitter
c.1712-130T>C Single submitter
c.1937-144del Single submitter
c.1937-144dup Single submitter
c.1937-38_1937-19del Single submitter hereditary diffuse gastric adenocarcinoma
c.2164+17insA Single submitter hereditary neoplastic syndrome
c.2164+322A>T Single submitter
c.2165-173G>A Single submitter
c.2165-213G>A Single submitter
c.2295+14del Single submitter hereditary diffuse gastric adenocarcinoma
c.2295+488T>A Single submitter
c.2296-31_2296-5dup Single submitter hereditary diffuse gastric adenocarcinoma
c.2439+156_2439+170del Single submitter
c.2439+162del Single submitter
c.2440-325del Single submitter
c.48+52_48+62dup Single submitter
c.48+62_48+63insCGTGCCCCAGCCCTGCGCCC Single submitter
c.49-295A>C Single submitter
c.531+19del Single submitter hereditary diffuse gastric adenocarcinoma
c.687+390_687+394dup Single submitter
c.687+394dup Single submitter
c.832+239del Single submitter
c.832+239dup Single submitter
c.833-267del Single submitter
c.833-268_833-267del Single submitter
c.-276T>C Single submitter
c.-294A>G Single submitter
c.*1_*2delinsA Single submitter hereditary diffuse gastric adenocarcinoma
c.*1693G>T Single submitter hereditary diffuse gastric adenocarcinoma
c.*1G>C Single submitter hereditary diffuse gastric adenocarcinoma
c.*209C>T Single submitter hereditary diffuse gastric adenocarcinoma
c.*3G>A Single submitter hereditary diffuse gastric adenocarcinoma
c.*4A>T Single submitter hereditary diffuse gastric adenocarcinoma
c.*8G>C Single submitter hereditary diffuse gastric adenocarcinoma
c.*9A>C Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala275= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala636= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala67= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala691_Ala692= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala692_Gly693= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala802= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ala824= Single submitter hereditary diffuse gastric adenocarcinoma
p.Arg222= Single submitter hereditary diffuse gastric adenocarcinoma
p.Arg868= Single submitter hereditary diffuse gastric adenocarcinoma
p.Asn431= Single submitter hereditary diffuse gastric adenocarcinoma
p.Asn558= Single submitter hereditary diffuse gastric adenocarcinoma
p.Asp479= Single submitter hereditary diffuse gastric adenocarcinoma
p.Asp528= Single submitter hereditary diffuse gastric adenocarcinoma
p.Asp828= Single submitter hereditary diffuse gastric adenocarcinoma
p.Asp856= Single submitter hereditary diffuse gastric adenocarcinoma
p.Gln255= Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu210= Single submitter hereditary diffuse gastric adenocarcinoma
p.Glu596= Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly148= Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly169= Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly196= Single submitter hereditary diffuse gastric adenocarcinoma
p.Gly420= Single submitter hereditary diffuse gastric adenocarcinoma
p.His123= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ile525= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ile584= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ile665= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ile713= Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu718= Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu727= Single submitter hereditary diffuse gastric adenocarcinoma
p.Leu742= Single submitter hereditary diffuse gastric adenocarcinoma
p.Lys168= Single submitter hereditary diffuse gastric adenocarcinoma
p.Phe142= Single submitter hereditary diffuse gastric adenocarcinoma
p.Phe462= Single submitter hereditary diffuse gastric adenocarcinoma
p.Phe69= Single submitter hereditary diffuse gastric adenocarcinoma
p.Phe730= Single submitter hereditary diffuse gastric adenocarcinoma
p.Pro159= Single submitter hereditary diffuse gastric adenocarcinoma
p.Pro654= Single submitter hereditary diffuse gastric adenocarcinoma
p.Pro801= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ser111= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ser356= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ser586= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ser70= Single submitter hereditary diffuse gastric adenocarcinoma
p.Ser793= Single submitter hereditary diffuse gastric adenocarcinoma
p.Thr227= Single submitter hereditary diffuse gastric adenocarcinoma
p.Thr279= Single submitter hereditary diffuse gastric adenocarcinoma
p.Thr357= Single submitter hereditary diffuse gastric adenocarcinoma
p.Thr378= Single submitter hereditary diffuse gastric adenocarcinoma
p.Thr578= Single submitter hereditary diffuse gastric adenocarcinoma
p.Thr580= Single submitter hereditary diffuse gastric adenocarcinoma
p.Thr631_His632= Single submitter hereditary diffuse gastric adenocarcinoma
p.Tyr296= Single submitter hereditary diffuse gastric adenocarcinoma
p.Val17= Single submitter hereditary diffuse gastric adenocarcinoma
p.Val252= Single submitter hereditary diffuse gastric adenocarcinoma
p.Val281= Single submitter hereditary diffuse gastric adenocarcinoma
c.2296-670T>A No assertion criteria

Benign/Likely benign 353

Showing the top 300 by review status; the full set is in the sitemap.

c.1008+8dup Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1711+9G>A Multiple submitters hereditary breast carcinoma
c.1711+9G>C Multiple submitters ovarian cancer
c.1712-37T>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2165-11dup Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2296-9dup Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2439+10C>T Multiple submitters Breast and/or ovarian cancer
c.2440-126A>G Multiple submitters
c.2440-6C>G Multiple submitters Breast and/or ovarian cancer
c.388-17A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.388-44G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.48+15_48+16del Multiple submitters hereditary breast carcinoma
c.48+19C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.49-8del Multiple submitters hereditary diffuse gastric adenocarcinoma
c.49-8dup Multiple submitters hereditary neoplastic syndrome
c.532-18C>T Multiple submitters Breast and/or ovarian cancer
c.532-9dup Multiple submitters hereditary diffuse gastric adenocarcinoma
c.832+17G>C Multiple submitters hereditary neoplastic syndrome
c.832+9A>T Multiple submitters hereditary breast carcinoma
c.-49G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.-54G>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.*221dup Multiple submitters hereditary diffuse gastric adenocarcinoma
c.*6T>C Multiple submitters hereditary neoplastic syndrome
c.*746C>A Multiple submitters Hereditary cancer
p.Ala102= Multiple submitters hereditary neoplastic syndrome
p.Ala130= Multiple submitters hereditary neoplastic syndrome
p.Ala241= Multiple submitters hereditary neoplastic syndrome
p.Ala286= Multiple submitters CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala298= Multiple submitters Breast and/or ovarian cancer
p.Ala299= Multiple submitters hereditary neoplastic syndrome
p.Ala34= Multiple submitters hereditary neoplastic syndrome
p.Ala347= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ala348= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ala408= Multiple submitters Breast and/or ovarian cancer
p.Ala411= Multiple submitters CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala439= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ala530= Multiple submitters hereditary neoplastic syndrome
p.Ala541= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ala592= Multiple submitters hereditary neoplastic syndrome
p.Ala634= Multiple submitters hereditary neoplastic syndrome
p.Ala657= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ala691= Multiple submitters hereditary neoplastic syndrome
p.Ala719= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ala788= Multiple submitters hereditary neoplastic syndrome
p.Ala818= Multiple submitters hereditary neoplastic syndrome
p.Arg124= Multiple submitters hereditary neoplastic syndrome
p.Arg209= Multiple submitters hereditary breast carcinoma
p.Arg321= Multiple submitters hereditary neoplastic syndrome
p.Arg335= Multiple submitters hereditary neoplastic syndrome
p.Arg50= Multiple submitters hereditary neoplastic syndrome
p.Arg527= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Arg63= Multiple submitters hereditary neoplastic syndrome
p.Arg65= Multiple submitters hereditary neoplastic syndrome
p.Arg733= Multiple submitters hereditary neoplastic syndrome
p.Arg74= Multiple submitters hereditary neoplastic syndrome
p.Arg749= Multiple submitters hereditary neoplastic syndrome
p.Arg784= Multiple submitters Breast and/or ovarian cancer
p.Arg800= Multiple submitters hereditary neoplastic syndrome
p.Asn117= Multiple submitters hereditary neoplastic syndrome
p.Asn144= Multiple submitters hereditary neoplastic syndrome
p.Asn174= Multiple submitters hereditary neoplastic syndrome
p.Asn238= Multiple submitters Breast and/or ovarian cancer
p.Asn240= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asn256= Multiple submitters hereditary neoplastic syndrome
p.Asn258= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asn320= Multiple submitters hereditary neoplastic syndrome
p.Asn322= Multiple submitters hereditary neoplastic syndrome
p.Asn369= Multiple submitters hereditary breast carcinoma
p.Asn376= Multiple submitters hereditary neoplastic syndrome
p.Asn432= Multiple submitters Breast and/or ovarian cancer
p.Asn458= Multiple submitters hereditary neoplastic syndrome
p.Asn481= Multiple submitters hereditary neoplastic syndrome
p.Asn531= Multiple submitters hereditary neoplastic syndrome
p.Asn536= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asn622= Multiple submitters hereditary neoplastic syndrome
p.Asn666= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asn785= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asn867= Multiple submitters hereditary neoplastic syndrome
p.Asp155= Multiple submitters hereditary neoplastic syndrome
p.Asp183= Multiple submitters hereditary neoplastic syndrome
p.Asp288= Multiple submitters hereditary neoplastic syndrome
p.Asp290= Multiple submitters CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Asp291= Multiple submitters hereditary neoplastic syndrome
p.Asp313= Multiple submitters hereditary neoplastic syndrome
p.Asp334= Multiple submitters hereditary neoplastic syndrome
p.Asp349= Multiple submitters Breast and/or ovarian cancer
p.Asp400= Multiple submitters hereditary neoplastic syndrome
p.Asp418= Multiple submitters hereditary neoplastic syndrome
p.Asp419= Multiple submitters hereditary neoplastic syndrome
p.Asp498= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asp514= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asp587= Multiple submitters hereditary neoplastic syndrome
p.Asp590= Multiple submitters hereditary neoplastic syndrome
p.Asp616= Multiple submitters hereditary neoplastic syndrome
p.Asp618= Multiple submitters hereditary neoplastic syndrome
p.Asp72= Multiple submitters hereditary neoplastic syndrome
p.Asp756= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asp764= Multiple submitters Breast and/or ovarian cancer
p.Asp766= Multiple submitters hereditary neoplastic syndrome
p.Asp777= Multiple submitters hereditary neoplastic syndrome
p.Asp786= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asp805= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asp812= Multiple submitters hereditary neoplastic syndrome
p.Asp854= Multiple submitters hereditary neoplastic syndrome
p.Asp860= Multiple submitters hereditary neoplastic syndrome
p.Asp881= Multiple submitters hereditary neoplastic syndrome
p.Asp882= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Cys163= Multiple submitters hereditary neoplastic syndrome
p.Cys22= Multiple submitters hereditary neoplastic syndrome
p.Cys28= Multiple submitters prostate cancer
p.Cys60= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Cys695= Multiple submitters hereditary neoplastic syndrome
p.Gln152= Multiple submitters hereditary neoplastic syndrome
p.Gln264= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gln307= Multiple submitters hereditary neoplastic syndrome
p.Gln422= Multiple submitters hereditary neoplastic syndrome
p.Gln449= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gln503= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gln610= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gln699= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Glu138= Multiple submitters hereditary neoplastic syndrome
p.Glu218= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Glu24= Multiple submitters hereditary neoplastic syndrome
p.Glu353= Multiple submitters hereditary neoplastic syndrome
p.Glu388= Multiple submitters hereditary neoplastic syndrome
p.Glu410= Multiple submitters hereditary neoplastic syndrome
p.Glu512= Multiple submitters hereditary neoplastic syndrome
p.Glu534= Multiple submitters hereditary neoplastic syndrome
p.Glu547= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Glu551= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Glu554= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Glu629= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Glu648= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Glu659= Multiple submitters Breast and/or ovarian cancer
p.Glu682= Multiple submitters hereditary neoplastic syndrome
p.Glu739= Multiple submitters hereditary neoplastic syndrome
p.Glu745= Multiple submitters hereditary neoplastic syndrome
p.Glu757= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Glu852= Multiple submitters hereditary neoplastic syndrome
p.Glu864= Multiple submitters hereditary neoplastic syndrome
p.Gly120= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gly2= Multiple submitters hereditary neoplastic syndrome
p.Gly212= Multiple submitters hereditary breast carcinoma
p.Gly239= Multiple submitters hereditary neoplastic syndrome
p.Gly269= Multiple submitters hereditary neoplastic syndrome
p.Gly354= Multiple submitters hereditary neoplastic syndrome
p.Gly434= Multiple submitters hereditary neoplastic syndrome
p.Gly441= Multiple submitters hereditary neoplastic syndrome
p.Gly633= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gly661= Multiple submitters hereditary neoplastic syndrome
p.Gly759= Multiple submitters hereditary neoplastic syndrome
p.Gly775= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gly78= Multiple submitters hereditary neoplastic syndrome
p.Gly81= Multiple submitters hereditary neoplastic syndrome
p.Gly839= Multiple submitters hereditary neoplastic syndrome
p.Gly866= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Gly877= Multiple submitters hereditary neoplastic syndrome
p.Gly879= Multiple submitters hereditary neoplastic syndrome
p.His122= Multiple submitters hereditary neoplastic syndrome
p.His29= Multiple submitters hereditary neoplastic syndrome
p.His453= Multiple submitters hereditary breast ovarian cancer syndrome
p.His555= Multiple submitters hereditary neoplastic syndrome
p.His97= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ile161= Multiple submitters hereditary neoplastic syndrome
p.Ile207= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ile250= Multiple submitters hereditary neoplastic syndrome
p.Ile300= Multiple submitters hereditary neoplastic syndrome
p.Ile326= Multiple submitters hereditary neoplastic syndrome
p.Ile393= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ile451= Multiple submitters hereditary neoplastic syndrome
p.Ile485= Multiple submitters hereditary neoplastic syndrome
p.Ile650= Multiple submitters hereditary breast carcinoma
p.Ile707= Multiple submitters hereditary neoplastic syndrome
p.Ile717= Multiple submitters hereditary neoplastic syndrome
p.Ile807= Multiple submitters hereditary neoplastic syndrome
p.Ile96= Multiple submitters hereditary neoplastic syndrome
p.Leu11= Multiple submitters hereditary neoplastic syndrome
p.Leu116= Multiple submitters hereditary neoplastic syndrome
p.Leu15= Multiple submitters hereditary neoplastic syndrome
p.Leu175= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Leu21= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Leu220= Multiple submitters hereditary neoplastic syndrome
p.Leu276= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Leu305= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Leu355= Multiple submitters ovarian cancer
p.Leu396= Multiple submitters hereditary neoplastic syndrome
p.Leu416= Multiple submitters hereditary neoplastic syndrome
p.Leu436= Multiple submitters Breast and/or ovarian cancer
p.Leu442= Multiple submitters hereditary neoplastic syndrome
p.Leu46= Multiple submitters hereditary neoplastic syndrome
p.Leu478= Multiple submitters hereditary neoplastic syndrome
p.Leu52= Multiple submitters hereditary neoplastic syndrome
p.Leu564= Multiple submitters hereditary neoplastic syndrome
p.Leu582= Multiple submitters Breast and/or ovarian cancer
p.Leu583= Multiple submitters hereditary neoplastic syndrome
p.Leu630= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Leu669= Multiple submitters hereditary neoplastic syndrome
p.Leu681= Multiple submitters hereditary neoplastic syndrome
p.Leu705= Multiple submitters hereditary neoplastic syndrome
p.Leu711= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Leu728= Multiple submitters hereditary neoplastic syndrome
p.Leu772= Multiple submitters hereditary neoplastic syndrome
p.Leu776= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Leu831= Multiple submitters hereditary neoplastic syndrome
p.Leu845= Multiple submitters hereditary neoplastic syndrome
p.Leu872= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Lys109= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Lys182= Multiple submitters hereditary breast carcinoma
p.Lys187= Multiple submitters hereditary neoplastic syndrome
p.Lys215= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Lys259= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Lys268= Multiple submitters hereditary neoplastic syndrome
p.Lys381= Multiple submitters hereditary neoplastic syndrome
p.Lys608= Multiple submitters hereditary neoplastic syndrome
p.Lys655= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Lys76= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Lys86= Multiple submitters hereditary neoplastic syndrome
p.Phe231= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Phe262= Multiple submitters hereditary neoplastic syndrome
p.Phe267= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Phe338= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Phe39= Multiple submitters hereditary neoplastic syndrome
p.Phe499= Multiple submitters hereditary neoplastic syndrome
p.Phe553= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Phe601= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Phe602= Multiple submitters hereditary neoplastic syndrome
p.Phe767= Multiple submitters hereditary neoplastic syndrome
p.Pro125= Multiple submitters CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Pro126= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Pro170= Multiple submitters hereditary neoplastic syndrome
p.Pro200= Multiple submitters hereditary neoplastic syndrome
p.Pro201= Multiple submitters hereditary neoplastic syndrome
p.Pro25= Multiple submitters hereditary neoplastic syndrome
p.Pro260= Multiple submitters hereditary neoplastic syndrome
p.Pro309= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Pro312= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Pro377= Multiple submitters hereditary neoplastic syndrome
p.Pro404= Multiple submitters hereditary neoplastic syndrome
p.Pro461= Multiple submitters hereditary neoplastic syndrome
p.Pro484= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Pro488= Multiple submitters hereditary neoplastic syndrome
p.Pro573= Multiple submitters hereditary neoplastic syndrome
p.Pro607= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Pro620= Multiple submitters Breast and/or ovarian cancer
p.Pro708= Multiple submitters hereditary neoplastic syndrome
p.Pro740= Multiple submitters hereditary neoplastic syndrome
p.Pro744= Multiple submitters Breast and/or ovarian cancer
p.Pro780= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Pro789= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Pro822= Multiple submitters hereditary neoplastic syndrome
p.Pro825= Multiple submitters CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Pro88= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ser131= Multiple submitters hereditary neoplastic syndrome
p.Ser133= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ser146= Multiple submitters hereditary neoplastic syndrome
p.Ser162= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ser180= Multiple submitters hereditary neoplastic syndrome
p.Ser236= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ser280= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ser306= Multiple submitters hereditary breast carcinoma
p.Ser337= Multiple submitters hereditary neoplastic syndrome
p.Ser465= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ser5= Multiple submitters hereditary neoplastic syndrome
p.Ser507= Multiple submitters hereditary neoplastic syndrome
p.Ser543= Multiple submitters hereditary neoplastic syndrome
p.Ser770= Multiple submitters hereditary neoplastic syndrome
p.Ser829= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ser838= Multiple submitters hereditary breast carcinoma
p.Ser840= Multiple submitters Breast and/or ovarian cancer
p.Ser850= Multiple submitters hereditary neoplastic syndrome
p.Ser851= Multiple submitters hereditary neoplastic syndrome
p.Ter883= Multiple submitters hereditary neoplastic syndrome
p.Thr106= Multiple submitters hereditary neoplastic syndrome
p.Thr112= Multiple submitters hereditary neoplastic syndrome
p.Thr141= Multiple submitters hereditary neoplastic syndrome
p.Thr217= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Thr251= Multiple submitters hereditary breast carcinoma
p.Thr285= Multiple submitters hereditary neoplastic syndrome
p.Thr287= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Thr295= Multiple submitters hereditary neoplastic syndrome
p.Thr303= Multiple submitters hereditary neoplastic syndrome
p.Thr323= Multiple submitters hereditary neoplastic syndrome
p.Thr330= Multiple submitters hereditary neoplastic syndrome
p.Thr331= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Thr340= Multiple submitters Breast and/or ovarian cancer
p.Thr364= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Thr38= Multiple submitters hereditary neoplastic syndrome
p.Thr394= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Thr395= Multiple submitters hereditary neoplastic syndrome
p.Thr40= Multiple submitters hereditary neoplastic syndrome
p.Thr406= Multiple submitters hereditary neoplastic syndrome
p.Thr414= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Thr426= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Thr438= Multiple submitters hereditary neoplastic syndrome
p.Thr468= Multiple submitters hereditary neoplastic syndrome
p.Thr472= Multiple submitters hereditary neoplastic syndrome
p.Thr515= Multiple submitters hereditary neoplastic syndrome
p.Thr529= Multiple submitters hereditary neoplastic syndrome
p.Thr539= Multiple submitters hereditary neoplastic syndrome
p.Thr560= Multiple submitters Breast and/or ovarian cancer

Likely benign 907

Showing the top 300 by review status; the full set is in the sitemap.

c.1138-3C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.163+4_163+6dup Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.164-4G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.387+6T>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.48+5C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.49-3C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.49-8C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.49-9C>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala289Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Ala735Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala817= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala817Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg124Cys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Arg124His Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Arg224Cys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Arg335Gln Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Arg54Gly Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Arg54Lys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg74Gln Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Arg90Gln Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asn390= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Asn432Lys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Asn622Ser Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asn674Tyr Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asp244Gly Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asp433Asn Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asp498Ala Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asp72Asn Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asp777Asn Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln136= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gln23= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Glu167Lys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Glu58Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Glu781Asp Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly2Ser Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly31Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Gly500= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly62Ser Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Gly693Ser Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly879Ser Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Leu14_Leu15dup Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Leu15dup Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Leu711Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Leu99= Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Phe75Leu Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Pro373Leu Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Pro3Arg Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Pro42Leu Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Ser838Gly Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Thr115Met Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Thr340Met Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Thr378Pro Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Thr379Met Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Thr38Lys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Thr38Met Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Thr562Ala Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Trp409Arg Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Val132Ile Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Val242Ile Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Val392Ile Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Val425Ile Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Val454Ile Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Val473Ile Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Val55Gly Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Val685Met Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
c.1008+12G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1008+12G>T Multiple submitters hereditary neoplastic syndrome
c.1008+15G>A Multiple submitters hereditary neoplastic syndrome
c.1008+16G>C Multiple submitters hereditary neoplastic syndrome
c.1008+18T>A Multiple submitters hereditary neoplastic syndrome
c.1008+5_1008+8dup Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1008+7G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1008+8G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1008+8G>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1009-10C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1009-12A>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1009-13G>A Multiple submitters hereditary neoplastic syndrome
c.1009-13G>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1009-13G>T Multiple submitters hereditary neoplastic syndrome
c.1009-14C>G Multiple submitters hereditary neoplastic syndrome
c.1009-16_1009-15del Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1009-16G>A Multiple submitters hereditary neoplastic syndrome
c.1009-17T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1009-18G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1009-20T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1009-4G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1009-5T>C Multiple submitters hereditary neoplastic syndrome
c.1009-6C>T Multiple submitters hereditary neoplastic syndrome
c.1009-8C>T Multiple submitters hereditary neoplastic syndrome
c.1137+10T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1137+20G>A Multiple submitters hereditary neoplastic syndrome
c.1137+20G>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1137+8T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1137+9A>C Multiple submitters hereditary neoplastic syndrome
c.1138-15C>T Multiple submitters hereditary neoplastic syndrome
c.1138-17A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1138-19A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1138-44G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1138-5T>G Multiple submitters hereditary neoplastic syndrome
c.1138-7T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1138-9G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1320+12A>T Multiple submitters hereditary neoplastic syndrome
c.1320+9G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1320+9G>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1320+9G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1321-10T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1321-11C>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1321-11del Multiple submitters hereditary neoplastic syndrome
c.1321-14T>C Multiple submitters hereditary neoplastic syndrome
c.1321-17T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1321-18A>G Multiple submitters hereditary neoplastic syndrome
c.1321-19C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1321-5T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1321-8C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1565+7G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1565+9G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1566-10C>G Multiple submitters hereditary neoplastic syndrome
c.1566-10C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1566-13T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1566-16G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1566-17A>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1566-17A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1566-20C>T Multiple submitters hereditary neoplastic syndrome
c.1566-6G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1566-7C>T Multiple submitters hereditary neoplastic syndrome
c.1566-8C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.163+10C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.163+14G>T Multiple submitters hereditary neoplastic syndrome
c.163+16C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.163+17G>A Multiple submitters hereditary neoplastic syndrome
c.163+17G>C Multiple submitters hereditary neoplastic syndrome
c.163+18G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.163+20G>A Multiple submitters hereditary neoplastic syndrome
c.163+7G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.163+8C>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.163+9G>A Multiple submitters hereditary neoplastic syndrome
c.164-10T>C Multiple submitters hereditary neoplastic syndrome
c.164-12T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.164-16G>A Multiple submitters hereditary neoplastic syndrome
c.164-17_164-16del Multiple submitters hereditary diffuse gastric adenocarcinoma
c.164-17T>C Multiple submitters hereditary neoplastic syndrome
c.164-20C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.164-45T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.164-6C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.164-7C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.164-9G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1711+10C>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1711+10C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1711+11C>T Multiple submitters hereditary neoplastic syndrome
c.1711+20G>T Multiple submitters hereditary neoplastic syndrome
c.1711+7_1711+9dup Multiple submitters hereditary neoplastic syndrome
c.1711+7G>T Multiple submitters hereditary neoplastic syndrome
c.1711+9del Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1712-13T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1712-16G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1936+10T>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1936+12A>G Multiple submitters hereditary neoplastic syndrome
c.1936+8C>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1936+8C>T Multiple submitters hereditary neoplastic syndrome
c.1936+9C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1937-4C>G Multiple submitters hereditary neoplastic syndrome
c.2164+10G>C Multiple submitters hereditary neoplastic syndrome
c.2164+10G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2164+14G>A Multiple submitters hereditary neoplastic syndrome
c.2164+17A>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2164+7C>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2164+8C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2164+9A>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2165-10A>C Multiple submitters hereditary neoplastic syndrome
c.2165-12C>G Multiple submitters hereditary neoplastic syndrome
c.2165-13C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2165-14C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2165-19G>C Multiple submitters hereditary neoplastic syndrome
c.2165-20T>C Multiple submitters hereditary neoplastic syndrome
c.2165-4C>T Multiple submitters hereditary neoplastic syndrome
c.2165-6T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2165-9C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2295+14A>G Multiple submitters hereditary breast carcinoma
c.2295+15C>T Multiple submitters hereditary neoplastic syndrome
c.2295+16C>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2295+8T>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2296-15C>G Multiple submitters hereditary neoplastic syndrome
c.2296-15C>T Multiple submitters hereditary neoplastic syndrome
c.2296-16C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2296-18A>C Multiple submitters hereditary neoplastic syndrome
c.2296-18A>G Multiple submitters hereditary neoplastic syndrome
c.2296-19C>T Multiple submitters hereditary neoplastic syndrome
c.2296-7T>C Multiple submitters hereditary neoplastic syndrome
c.2296-8C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2439+13C>T Multiple submitters hereditary neoplastic syndrome
c.2439+14G>A Multiple submitters hereditary neoplastic syndrome
c.2439+18_2439+32del Multiple submitters hereditary neoplastic syndrome
c.2439+9T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2439+9T>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2440-10T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2440-11T>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2440-13C>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2440-13C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2440-14C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2440-16G>A Multiple submitters hereditary neoplastic syndrome
c.2440-16G>T Multiple submitters hereditary neoplastic syndrome
c.2440-18T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2440-19T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2440-4T>C Multiple submitters hereditary neoplastic syndrome
c.2440-5T>C Multiple submitters hereditary neoplastic syndrome
c.2440-6C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2440-6del Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2440-7del Multiple submitters hereditary diffuse gastric adenocarcinoma
c.387+18T>C Multiple submitters hereditary neoplastic syndrome
c.387+27C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.387+7T>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.387+9G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.388-12_388-10del Multiple submitters hereditary diffuse gastric adenocarcinoma
c.388-12C>T Multiple submitters hereditary neoplastic syndrome
c.388-16T>A Multiple submitters hereditary neoplastic syndrome
c.388-17A>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.388-18C>T Multiple submitters hereditary neoplastic syndrome
c.388-20C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.388-6T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.388-7C>G Multiple submitters hereditary neoplastic syndrome
c.388-7C>T Multiple submitters hereditary neoplastic syndrome
c.48+10A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.48+12C>A Multiple submitters hereditary neoplastic syndrome
c.48+12C>G Multiple submitters hereditary neoplastic syndrome
c.48+136C>G Multiple submitters
c.48+13C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.48+16T>C Multiple submitters hereditary neoplastic syndrome
c.48+6_48+7delinsTT Multiple submitters hereditary neoplastic syndrome
c.48+7C>T Multiple submitters hereditary neoplastic syndrome
c.48+8G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.49-10C>T Multiple submitters hereditary neoplastic syndrome
c.49-11C>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.49-12C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.49-13dup Multiple submitters hereditary diffuse gastric adenocarcinoma
c.49-15T>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.49-16C>T Multiple submitters hereditary neoplastic syndrome
c.49-18A>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.49-20C>T Multiple submitters hereditary neoplastic syndrome
c.49-4C>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.49-6C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.49-8C>A Multiple submitters hereditary neoplastic syndrome
c.531+10G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.531+16C>A Multiple submitters hereditary neoplastic syndrome
c.531+16C>T Multiple submitters hereditary neoplastic syndrome
c.531+20G>A Multiple submitters hereditary neoplastic syndrome
c.531+8A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.532-13A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.532-15T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.532-17T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.532-18del Multiple submitters hereditary diffuse gastric adenocarcinoma
c.532-4T>C Multiple submitters hereditary neoplastic syndrome
c.532-7T>C Multiple submitters hereditary neoplastic syndrome
c.532-8G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.687+11C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.687+18G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.687+21del Multiple submitters hereditary neoplastic syndrome
c.687+33G>A Multiple submitters
c.687+77G>A Multiple submitters
c.687+7A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.688-10G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.688-11G>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.688-14C>T Multiple submitters endometrial carcinoma
c.688-15A>T Multiple submitters hereditary neoplastic syndrome
c.688-18C>G Multiple submitters hereditary neoplastic syndrome
c.688-18C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.688-18del Multiple submitters hereditary neoplastic syndrome
c.688-4T>C Multiple submitters hereditary neoplastic syndrome
c.832+17G>A Multiple submitters hereditary neoplastic syndrome
c.832+7C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.832+9A>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.832+9A>G Multiple submitters hereditary neoplastic syndrome
c.833-14T>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.833-17T>A Multiple submitters hereditary neoplastic syndrome
c.833-17T>C Multiple submitters Breast and/or ovarian cancer
c.833-19T>C Multiple submitters hereditary neoplastic syndrome
c.833-20A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.833-20A>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.833-4C>T Multiple submitters hereditary neoplastic syndrome
c.833-6T>C Multiple submitters hereditary neoplastic syndrome
c.833-9C>T Multiple submitters hereditary neoplastic syndrome
c.-197A>C Multiple submitters
c.-21G>C Multiple submitters
c.-84G>A Multiple submitters prostate cancer
c.*17G>A Multiple submitters hereditary neoplastic syndrome
c.*20C>T Multiple submitters hereditary neoplastic syndrome
p.Ala234= Multiple submitters Breast and/or ovarian cancer
p.Ala301= Multiple submitters hereditary neoplastic syndrome
p.Ala401= Multiple submitters hereditary neoplastic syndrome
p.Ala510= Multiple submitters hereditary neoplastic syndrome
p.Arg492= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Arg550= Multiple submitters hereditary neoplastic syndrome
p.Arg6= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Arg734= Multiple submitters hereditary neoplastic syndrome
p.Arg87= Multiple submitters hereditary neoplastic syndrome
p.Arg90= Multiple submitters hereditary neoplastic syndrome
p.Asn294= Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asn405= Multiple submitters hereditary neoplastic syndrome
p.Asn570= Multiple submitters hereditary neoplastic syndrome
p.Asn93= Multiple submitters hereditary neoplastic syndrome
p.Asp198= Multiple submitters hereditary neoplastic syndrome

Uncertain significance 2154

Showing the top 300 by review status; the full set is in the sitemap.

c.1566-1G>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1566-2A>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1711+5G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.1712-2A>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.2164+2dup Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.2164+2T>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.387+1G>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.49-3C>A Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.687+2T>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.-45C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.-50C>G Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.-50C>T Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.-58GCCCG[3] Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
c.-72T>C Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Ala455Thr Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Ala843fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Arg749Trp Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asp254His Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asp538Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Glu26Gln Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Glu35Asp Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Glu836fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Gly212Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Gly2Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Gly49Arg Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.His121Gln Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Leu21Ile Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Leu21Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Leu721Val Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Lys179Glu Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Phe171Cys Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Phe205Ser Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Pro27Ser Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Pro3Ser Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Pro799Arg Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Ser850fs Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Thr38Pro Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Thr529Ala Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Trp865Ter Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome
p.Val202Leu Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Val41Leu Expert panel CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
c.1137+4A>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1137+4A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1565+3_1565+6del Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1566-3C>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1566-9C>A Multiple submitters hereditary neoplastic syndrome
c.163+5G>T Multiple submitters hereditary neoplastic syndrome
c.164-3C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1711+6G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1712-15T>G Multiple submitters hereditary neoplastic syndrome
c.1712-2A>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.1712-3T>G Multiple submitters hereditary neoplastic syndrome
c.1937-383A>G Multiple submitters hereditary neoplastic syndrome
c.2164+15C>T Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2295+5G>A Multiple submitters hereditary neoplastic syndrome
c.2295+5G>C Multiple submitters hereditary diffuse gastric adenocarcinoma
c.2296-17A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.387+2T>A Multiple submitters hereditary neoplastic syndrome
c.387+2T>C Multiple submitters hereditary neoplastic syndrome
c.387+3A>G Multiple submitters hereditary neoplastic syndrome
c.687+2dup Multiple submitters hereditary neoplastic syndrome
c.687+5G>A Multiple submitters hereditary neoplastic syndrome
c.833-10A>G Multiple submitters hereditary diffuse gastric adenocarcinoma
c.-1C>G Multiple submitters Hereditary cancer
c.-288del Multiple submitters hereditary diffuse gastric adenocarcinoma
c.-44G>A Multiple submitters hereditary diffuse gastric adenocarcinoma
c.-8G>A Multiple submitters hereditary neoplastic syndrome
p.Ala10Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala130Gly Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala130Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala137Arg Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Ala137Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala226Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala234Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala241Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala286Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala298Asp Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala298Pro Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala298Val Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala299Thr Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala347Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala34Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala359Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala361Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala389Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala401Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala403Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala408Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala408Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala408Pro Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala411Thr Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala439Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala446Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala446Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala455Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala483Val Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala510Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala530Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala541Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala546Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala563Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala563Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala563Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala563Val Multiple submitters CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Ala567Val Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala592Asp Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala592Ser Multiple submitters hereditary breast carcinoma ⚠
p.Ala592Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala617Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala617Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala617Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala634Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala634Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala691Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala698Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala709Ser Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala735Thr Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala778Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala778Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala788Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala788Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala802Gly Multiple submitters hereditary breast carcinoma ⚠
p.Ala802Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala817Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala824Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala824Val Multiple submitters hereditary breast carcinoma ⚠
p.Ala843Asp Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala843Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala873Gly Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Ala873Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala873Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg108Ser Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Arg151Ile Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg209Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg222Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg224Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg321Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg335Gly Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Arg43Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg492Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg492Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg50Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg50Gly Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Arg50Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg524Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg545Gly Multiple submitters hereditary breast carcinoma ⚠
p.Arg545Pro Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Arg545Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg550Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg550Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg550Thr Multiple submitters ovarian cancer ⚠
p.Arg598Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg605Gly Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Arg63Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg65Lys Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Arg696Lys Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Arg6His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg6Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg732Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg733Ser Multiple submitters ovarian cancer ⚠
p.Arg734Ile Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg734Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg734Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg74Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg74Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg74Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg774Gly Multiple submitters CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Arg779Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg784Cys Multiple submitters CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Arg784Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg784His Multiple submitters CDH1-related disorder ⚠
p.Arg784Leu Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Arg784Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg796Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg800Cys Multiple submitters hereditary breast carcinoma ⚠
p.Arg800Leu Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Arg868fs Multiple submitters hereditary neoplastic syndrome
p.Arg868Ser Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Arg87Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg87Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn117Ile Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn166Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn174Ile Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asn174Ser Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asn238Ser Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asn258del Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asn258Ser Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asn258Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn297Ser Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asn320Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn322Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn322Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn369Ser Multiple submitters hereditary breast carcinoma ⚠
p.Asn371Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn371Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn376Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn405Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn417His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn417Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn432Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn432del Multiple submitters hereditary neoplastic syndrome
p.Asn481Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn558Ile Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn570His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn570Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn589Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn591Asp Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asn591His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn591Ser Multiple submitters hereditary breast carcinoma ⚠
p.Asn613Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn622Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn622His Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asn622Ile Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asn622Tyr Multiple submitters hereditary breast carcinoma ⚠
p.Asn643His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn643Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn643Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn672Ser Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asn751del Multiple submitters hereditary neoplastic syndrome
p.Asn751Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn803Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn809Ser Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asn814Ser Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asn849Asp Multiple submitters hereditary breast carcinoma ⚠
p.Asn849Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp104Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp155Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp183_Lys184del Multiple submitters hereditary neoplastic syndrome
p.Asp183Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp198Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp198His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp198Val Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp288Asn Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp291Gly Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp292Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp292del Multiple submitters hereditary neoplastic syndrome
p.Asp308Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp308His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp308Val Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp313Val Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp334Glu Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp334Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp370Asn Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp418Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp419Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp433Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp443Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp476Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp479Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp479Glu Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp479Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp479His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp528Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp538Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp549Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp569Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp590Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp590Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp644Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp644His Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp676Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp72His Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp72Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp746Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp746Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp747Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp750Asn Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp756Gly Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp756His Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp764Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp764Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp766His Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp766Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp768Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp786Asn Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp805Gly Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp805His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp805Ser Multiple submitters hereditary breast carcinoma
p.Asp80His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp812del Multiple submitters hereditary diffuse gastric adenocarcinoma
p.Asp812Gly Multiple submitters blepharocheilodontic syndrome 1 ⚠
p.Asp812His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp834Asn Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp854Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp854Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp854Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp856Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp856Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp856Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp858Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp858Gly Multiple submitters hereditary diffuse gastric adenocarcinoma ⚠
p.Asp858His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp860Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp860His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp860Tyr Multiple submitters CDH1-related diffuse gastric and lobular breast cancer syndrome ⚠
p.Asp874His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp881Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp882Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp882His Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys163Arg Multiple submitters hereditary neoplastic syndrome ⚠