CDH12 — 130 ClinVar variants
All ClinVar germline CDH12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 110 flagged for review →
10 Benign · 13 Likely benign · 107 Uncertain significance
Full CDH12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 110
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDH12 p.Ala250Ser Uncertain significance Single submitter
- CDH12 p.Ala32Gly Uncertain significance Single submitter
- CDH12 p.Ala548Val Uncertain significance Single submitter
- CDH12 p.Ala616Val Uncertain significance Single submitter
- CDH12 p.Arg449Gly Uncertain significance Single submitter
- CDH12 p.Arg46Gln Uncertain significance Single submitter
- CDH12 p.Arg554Lys Uncertain significance Single submitter
- CDH12 p.Arg702His Uncertain significance Single submitter
- CDH12 p.Asn5Lys Uncertain significance Single submitter
- CDH12 p.Asn724Thr Uncertain significance Single submitter
- CDH12 p.Asn789Lys Uncertain significance Single submitter
- CDH12 p.Asp312Asn Uncertain significance Single submitter
- CDH12 p.Asp396Asn Uncertain significance Single submitter
- CDH12 p.Asp644Gly Uncertain significance Single submitter
- CDH12 p.Asp661Asn Uncertain significance Single submitter
- CDH12 p.Asp662His Uncertain significance Single submitter
- CDH12 p.Asp755Asn Uncertain significance Single submitter
- CDH12 p.Asp81Asn Uncertain significance Single submitter
- CDH12 p.Asp81Gly Uncertain significance Single submitter
- CDH12 p.Gly251Arg Uncertain significance Single submitter
- CDH12 p.Gly428Arg Uncertain significance Single submitter
- CDH12 p.Gly556Arg Uncertain significance Single submitter
- CDH12 p.His48Arg Uncertain significance Single submitter
- CDH12 p.Ile114Val Uncertain significance Single submitter
- CDH12 p.Ile202Val Uncertain significance Single submitter
- CDH12 p.Ile434Thr Uncertain significance Single submitter
- CDH12 p.Ile534Met Uncertain significance Single submitter
- CDH12 p.Ile626Val Uncertain significance Single submitter
- CDH12 p.Ile754Val Uncertain significance Single submitter
- CDH12 p.Leu276Ser Uncertain significance Single submitter
- CDH12 p.Leu353Phe Uncertain significance Single submitter
- CDH12 p.Lys641Asn Uncertain significance Single submitter
- CDH12 p.Met585Ile Uncertain significance Single submitter
- CDH12 p.Phe432Val Uncertain significance Single submitter
- CDH12 p.Pro25Gln Uncertain significance Single submitter
- CDH12 p.Pro25Leu Uncertain significance Single submitter
- CDH12 p.Pro25Thr Uncertain significance Single submitter
- CDH12 p.Pro577Ser Uncertain significance Single submitter
- CDH12 p.Pro701Arg Uncertain significance Single submitter
- CDH12 p.Ser613Arg Uncertain significance Single submitter
- CDH12 p.Ser735Leu Uncertain significance Single submitter
- CDH12 p.Thr215Lys Uncertain significance Single submitter
- CDH12 p.Thr21Ile Uncertain significance Single submitter
- CDH12 p.Thr30Ile Uncertain significance Single submitter
- CDH12 p.Thr3Ser Uncertain significance Single submitter
- CDH12 p.Thr88Ala Uncertain significance Single submitter
- CDH12 p.Val179Gly Uncertain significance Single submitter
- CDH12 p.Val217Ile Uncertain significance Single submitter
- CDH12 p.Val320Ile Uncertain significance Single submitter
- CDH12 p.Val371Ala Uncertain significance Single submitter
- CDH12 p.Val375Met Uncertain significance Single submitter
- CDH12 p.Val603Ala Uncertain significance Single submitter
- CDH12 p.Val747Ala Uncertain significance Single submitter
Predictors split 57
The independent predictors disagree with each other — read with care.
- CDH12 p.Glu349Asp Benign Multiple submitters
- CDH12 p.Ile475Thr Benign Multiple submitters
- CDH12 p.Ala730Thr Uncertain significance Single submitter
- CDH12 p.Arg268Leu Uncertain significance Single submitter
- CDH12 p.Arg46Trp Uncertain significance Single submitter
- CDH12 p.Arg553Gln Uncertain significance Single submitter
- CDH12 p.Arg553Gly Uncertain significance Single submitter
- CDH12 p.Arg588Gln Uncertain significance Single submitter
- CDH12 p.Asn194Ser Uncertain significance Single submitter
- CDH12 p.Asn307Asp Uncertain significance Single submitter
- CDH12 p.Asp118Asn Uncertain significance Single submitter
- CDH12 p.Asp162His Uncertain significance Single submitter
- CDH12 p.Asp322Tyr Uncertain significance Single submitter
- CDH12 p.Asp709Val Uncertain significance Single submitter
- CDH12 p.Asp727Asn Uncertain significance Single submitter
- CDH12 p.Asp762Tyr Uncertain significance Single submitter
- CDH12 p.Gln181Arg Uncertain significance Single submitter
- CDH12 p.Gln326Arg Uncertain significance Single submitter
- CDH12 p.Gln454Arg Uncertain significance Single submitter
- CDH12 p.Glu572Lys Uncertain significance Single submitter
- CDH12 p.Glu604Lys Uncertain significance Single submitter
- CDH12 p.Glu71Lys Uncertain significance Single submitter
- CDH12 p.Glu723Ala Uncertain significance Single submitter
- CDH12 p.Glu786Lys Uncertain significance Single submitter
- CDH12 p.Gly18Arg Uncertain significance Single submitter
- CDH12 p.Gly251Ala Uncertain significance Single submitter
- CDH12 p.Gly314Arg Uncertain significance Single submitter
- CDH12 p.Gly363Val Uncertain significance Single submitter
- CDH12 p.Gly615Glu Uncertain significance Single submitter
- CDH12 p.His659Leu Uncertain significance Single submitter
- CDH12 p.His718Arg Uncertain significance Single submitter
- CDH12 p.Leu778Val Uncertain significance Single submitter
- CDH12 p.Lys271Glu Uncertain significance Single submitter
- CDH12 p.Lys386Arg Uncertain significance Single submitter
- CDH12 p.Lys53Arg Uncertain significance Single submitter
- CDH12 p.Met391Val Uncertain significance Single submitter
- CDH12 p.Phe124Leu Uncertain significance Single submitter
- CDH12 p.Pro213Leu Uncertain significance Single submitter
- CDH12 p.Pro223Ser Uncertain significance Single submitter
- CDH12 p.Pro283Ala Uncertain significance Single submitter
- CDH12 p.Pro335Ser Uncertain significance Single submitter
- CDH12 p.Pro381Thr Uncertain significance Single submitter
- CDH12 p.Pro387Leu Uncertain significance Single submitter
- CDH12 p.Pro72Leu Uncertain significance Single submitter
- CDH12 p.Ser272Ile Uncertain significance Single submitter
- CDH12 p.Ser281Thr Uncertain significance Single submitter
- CDH12 p.Ser374Arg Uncertain significance Single submitter
- CDH12 p.Ser529Pro Likely benign Single submitter
- CDH12 p.Ser600Thr Uncertain significance Single submitter
- CDH12 p.Thr126Ala Uncertain significance Single submitter
- CDH12 p.Thr168Ile Uncertain significance Single submitter
- CDH12 p.Thr258Ile Uncertain significance Single submitter
- CDH12 p.Tyr200Phe Uncertain significance Single submitter
- CDH12 p.Val169Ile Uncertain significance Single submitter
- CDH12 p.Val309Ala Uncertain significance Single submitter
- CDH12 p.Val482Ile Uncertain significance Single submitter
- CDH12 p.Val497Met Uncertain significance Single submitter
All CDH12 variants
Benign 10
- c.1003-3C>T Multiple submitters
- p.Gln60= Multiple submitters
- p.Glu349Asp Multiple submitters ⚠
- p.Glu34Gln Multiple submitters
- p.Ile475Thr Multiple submitters ⚠
- p.Pro213= Multiple submitters
- p.Thr260= Multiple submitters
- p.Ala532= Single submitter
- p.Gly109= Single submitter
- p.Tyr741= Single submitter
Likely benign 13
- p.Asp780= Multiple submitters
- p.Ile598= Multiple submitters
- p.Ala131= Single submitter
- p.Ala548= Single submitter
- p.Ala616= Single submitter
- p.Leu222= Single submitter
- p.Leu757Pro Single submitter
- p.Met707Val Single submitter
- p.Pro190= Single submitter
- p.Pro207= Single submitter
- p.Ser529Pro Single submitter ⚠
- p.Val393= Single submitter
- p.Val491= Single submitter
Uncertain significance 107
- p.Ala250Ser Single submitter ⚠
- p.Ala32Gly Single submitter ⚠
- p.Ala548Val Single submitter ⚠
- p.Ala616Val Single submitter ⚠
- p.Ala730Thr Single submitter ⚠
- p.Arg268Leu Single submitter ⚠
- p.Arg449Gly Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Arg553Gln Single submitter ⚠
- p.Arg553Gly Single submitter ⚠
- p.Arg554Lys Single submitter ⚠
- p.Arg588Gln Single submitter ⚠
- p.Arg702His Single submitter ⚠
- p.Asn194Ser Single submitter ⚠
- p.Asn307Asp Single submitter ⚠
- p.Asn5Lys Single submitter ⚠
- p.Asn724Thr Single submitter ⚠
- p.Asn789Lys Single submitter ⚠
- p.Asp118Asn Single submitter ⚠
- p.Asp162His Single submitter ⚠
- p.Asp312Asn Single submitter ⚠
- p.Asp322Tyr Single submitter ⚠
- p.Asp396Asn Single submitter ⚠
- p.Asp644Gly Single submitter ⚠
- p.Asp661Asn Single submitter ⚠
- p.Asp662His Single submitter ⚠
- p.Asp709Val Single submitter ⚠
- p.Asp727Asn Single submitter ⚠
- p.Asp755Asn Single submitter ⚠
- p.Asp762Tyr Single submitter ⚠
- p.Asp81Asn Single submitter ⚠
- p.Asp81Gly Single submitter ⚠
- p.Gln181Arg Single submitter ⚠
- p.Gln326Arg Single submitter ⚠
- p.Gln454Arg Single submitter ⚠
- p.Glu572Lys Single submitter ⚠
- p.Glu604Lys Single submitter ⚠
- p.Glu71Lys Single submitter ⚠
- p.Glu723Ala Single submitter ⚠
- p.Glu786Lys Single submitter ⚠
- p.Gly18Arg Single submitter ⚠
- p.Gly251Ala Single submitter ⚠
- p.Gly251Arg Single submitter ⚠
- p.Gly314Arg Single submitter ⚠
- p.Gly363Val Single submitter ⚠
- p.Gly428Arg Single submitter ⚠
- p.Gly556Arg Single submitter ⚠
- p.Gly615Glu Single submitter ⚠
- p.His48Arg Single submitter ⚠
- p.His659Leu Single submitter ⚠
- p.His718Arg Single submitter ⚠
- p.Ile114Val Single submitter ⚠
- p.Ile202Val Single submitter ⚠
- p.Ile434Thr Single submitter ⚠
- p.Ile534Met Single submitter ⚠
- p.Ile626Val Single submitter ⚠
- p.Ile754Val Single submitter ⚠
- p.Leu276Ser Single submitter ⚠
- p.Leu353Phe Single submitter ⚠
- p.Leu778Val Single submitter ⚠
- p.Lys271Glu Single submitter ⚠
- p.Lys386Arg Single submitter ⚠
- p.Lys53Arg Single submitter ⚠
- p.Lys641Asn Single submitter ⚠
- p.Met391Val Single submitter ⚠
- p.Met585Ile Single submitter ⚠
- p.Phe124Leu Single submitter ⚠
- p.Phe432Val Single submitter ⚠
- p.Pro213Leu Single submitter ⚠
- p.Pro223Ser Single submitter ⚠
- p.Pro25Gln Single submitter ⚠
- p.Pro25Leu Single submitter ⚠
- p.Pro25Thr Single submitter ⚠
- p.Pro283Ala Single submitter ⚠
- p.Pro335Ser Single submitter ⚠
- p.Pro381Thr Single submitter ⚠
- p.Pro387Leu Single submitter ⚠
- p.Pro577Ser Single submitter ⚠
- p.Pro701Arg Single submitter ⚠
- p.Pro72Leu Single submitter ⚠
- p.Ser272Ile Single submitter ⚠
- p.Ser281Thr Single submitter ⚠
- p.Ser374Arg Single submitter ⚠
- p.Ser600Thr Single submitter ⚠
- p.Ser613Arg Single submitter ⚠
- p.Ser735Leu Single submitter ⚠
- p.Thr126Ala Single submitter ⚠
- p.Thr168Ile Single submitter ⚠
- p.Thr215Lys Single submitter ⚠
- p.Thr21Ile Single submitter ⚠
- p.Thr258Ile Single submitter ⚠
- p.Thr30Ile Single submitter ⚠
- p.Thr3Ser Single submitter ⚠
- p.Thr88Ala Single submitter ⚠
- p.Tyr200Phe Single submitter ⚠
- p.Val169Ile Single submitter ⚠
- p.Val179Gly Single submitter ⚠
- p.Val217Ile Single submitter ⚠
- p.Val309Ala Single submitter ⚠
- p.Val320Ile Single submitter ⚠
- p.Val371Ala Single submitter ⚠
- p.Val375Met Single submitter ⚠
- p.Val482Ile Single submitter ⚠
- p.Val497Met Single submitter ⚠
- p.Val603Ala Single submitter ⚠
- p.Val747Ala Single submitter ⚠