CDH6 — 69 ClinVar variants
All ClinVar germline CDH6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
2 Likely benign · 67 Uncertain significance
Full CDH6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDH6 p.Ala130Val Uncertain significance Single submitter
- CDH6 p.Ala489Ser Uncertain significance Single submitter
- CDH6 p.Ala706Val Uncertain significance Single submitter
- CDH6 p.Ala729Val Uncertain significance Single submitter
- CDH6 p.Ala739Val Uncertain significance Single submitter
- CDH6 p.Arg115Lys Uncertain significance Single submitter
- CDH6 p.Arg357Gln Uncertain significance Single submitter
- CDH6 p.Arg5Cys Uncertain significance Single submitter
- CDH6 p.Arg83Lys Uncertain significance Single submitter
- CDH6 p.Asn686Asp Uncertain significance Single submitter
- CDH6 p.Asp503Asn Uncertain significance Single submitter
- CDH6 p.Asp661His Uncertain significance Single submitter
- CDH6 p.Asp724Tyr Uncertain significance Single submitter
- CDH6 p.Asp748Gly Uncertain significance Single submitter
- CDH6 p.Asp779Glu Uncertain significance Single submitter
- CDH6 p.Gln408His Uncertain significance Single submitter
- CDH6 p.Glu560Lys Uncertain significance Single submitter
- CDH6 p.Glu684Val Uncertain significance Single submitter
- CDH6 p.Gly247Arg Uncertain significance Single submitter
- CDH6 p.Gly96Ala Uncertain significance Single submitter
- CDH6 p.His594Tyr Uncertain significance Single submitter
- CDH6 p.Ile402Val Uncertain significance Single submitter
- CDH6 p.Ile440Thr Uncertain significance Single submitter
- CDH6 p.Ile692Val Uncertain significance Single submitter
- CDH6 p.Leu40Pro Uncertain significance Single submitter
- CDH6 p.Lys649Glu Uncertain significance Single submitter
- CDH6 p.Met56Lys Uncertain significance Single submitter
- CDH6 p.Met780Thr Uncertain significance Single submitter
- CDH6 p.Pro517Ser Uncertain significance Single submitter
- CDH6 p.Ser200Arg Uncertain significance Single submitter
- CDH6 p.Ser443Leu Uncertain significance Single submitter
- CDH6 p.Thr19Ala Uncertain significance Single submitter
- CDH6 p.Thr344Ser Uncertain significance Single submitter
- CDH6 p.Thr67Ala Uncertain significance Single submitter
- CDH6 p.Thr703Ala Uncertain significance Single submitter
- CDH6 p.Thr728Ile Uncertain significance Single submitter
- CDH6 p.Val123Ile Uncertain significance Single submitter
- CDH6 p.Val197Ala Uncertain significance Single submitter
- CDH6 p.Val254Met Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- CDH6 p.Ala634Gly Uncertain significance Single submitter
- CDH6 p.Ala671Ser Uncertain significance Single submitter
- CDH6 p.Arg587Gln Uncertain significance Single submitter
- CDH6 p.Asn573Lys Uncertain significance Single submitter
- CDH6 p.Asp711Asn Uncertain significance Single submitter
- CDH6 p.Asp769Gly Uncertain significance Single submitter
- CDH6 p.Glu681Gly Uncertain significance Single submitter
- CDH6 p.Gly243Ser Uncertain significance Single submitter
- CDH6 p.Gly610Arg Uncertain significance Single submitter
- CDH6 p.Ile287Thr Uncertain significance Single submitter
- CDH6 p.Ile329Met Uncertain significance Single submitter
- CDH6 p.Ile329Val Uncertain significance Single submitter
- CDH6 p.Ile459Leu Uncertain significance Single submitter
- CDH6 p.Ile476Val Uncertain significance Single submitter
- CDH6 p.Leu63Val Uncertain significance Single submitter
- CDH6 p.Lys444Gln Uncertain significance Single submitter
- CDH6 p.Lys775Arg Uncertain significance Single submitter
- CDH6 p.Pro380Ser Uncertain significance Single submitter
- CDH6 p.Ser469Asn Uncertain significance Single submitter
- CDH6 p.Thr19Asn Uncertain significance Single submitter
- CDH6 p.Thr461Ile Uncertain significance Single submitter
- CDH6 p.Thr613Arg Uncertain significance Single submitter
- CDH6 p.Tyr419Phe Uncertain significance Single submitter
- CDH6 p.Val139Met Uncertain significance Single submitter
- CDH6 p.Val354Ala Uncertain significance Single submitter
- CDH6 p.Val373Met Likely benign Single submitter
- CDH6 p.Val382Ile Uncertain significance Single submitter
- CDH6 p.Val588Ile Uncertain significance Single submitter
- CDH6 p.Val746Leu Uncertain significance Single submitter
All CDH6 variants
Likely benign 2
- p.Val373Met Single submitter ⚠
- p.Val512Ile Single submitter
Uncertain significance 67
- p.Ala130Val Single submitter ⚠
- p.Ala489Ser Single submitter ⚠
- p.Ala634Gly Single submitter ⚠
- p.Ala671Ser Single submitter ⚠
- p.Ala706Val Single submitter ⚠
- p.Ala729Val Single submitter ⚠
- p.Ala739Val Single submitter ⚠
- p.Arg115Lys Single submitter ⚠
- p.Arg357Gln Single submitter ⚠
- p.Arg587Gln Single submitter ⚠
- p.Arg5Cys Single submitter ⚠
- p.Arg83Lys Single submitter ⚠
- p.Asn573Lys Single submitter ⚠
- p.Asn686Asp Single submitter ⚠
- p.Asp503Asn Single submitter ⚠
- p.Asp661His Single submitter ⚠
- p.Asp711Asn Single submitter ⚠
- p.Asp724Tyr Single submitter ⚠
- p.Asp748Gly Single submitter ⚠
- p.Asp769Gly Single submitter ⚠
- p.Asp779Glu Single submitter ⚠
- p.Gln408His Single submitter ⚠
- p.Glu560Lys Single submitter ⚠
- p.Glu681Gly Single submitter ⚠
- p.Glu684Val Single submitter ⚠
- p.Gly243Ser Single submitter ⚠
- p.Gly247Arg Single submitter ⚠
- p.Gly610Arg Single submitter ⚠
- p.Gly96Ala Single submitter ⚠
- p.His594Tyr Single submitter ⚠
- p.Ile287Thr Single submitter ⚠
- p.Ile329Met Single submitter ⚠
- p.Ile329Val Single submitter ⚠
- p.Ile402Val Single submitter ⚠
- p.Ile440Thr Single submitter ⚠
- p.Ile459Leu Single submitter ⚠
- p.Ile476Val Single submitter ⚠
- p.Ile692Val Single submitter ⚠
- p.Leu40Pro Single submitter ⚠
- p.Leu63Val Single submitter ⚠
- p.Lys444Gln Single submitter ⚠
- p.Lys649Glu Single submitter ⚠
- p.Lys775Arg Single submitter ⚠
- p.Met56Lys Single submitter ⚠
- p.Met780Thr Single submitter ⚠
- p.Pro380Ser Single submitter ⚠
- p.Pro517Ser Single submitter ⚠
- p.Ser200Arg Single submitter ⚠
- p.Ser443Leu Single submitter ⚠
- p.Ser469Asn Single submitter ⚠
- p.Thr19Ala Single submitter ⚠
- p.Thr19Asn Single submitter ⚠
- p.Thr344Ser Single submitter ⚠
- p.Thr461Ile Single submitter ⚠
- p.Thr613Arg Single submitter ⚠
- p.Thr67Ala Single submitter ⚠
- p.Thr703Ala Single submitter ⚠
- p.Thr728Ile Single submitter ⚠
- p.Tyr419Phe Single submitter ⚠
- p.Val123Ile Single submitter ⚠
- p.Val139Met Single submitter ⚠
- p.Val197Ala Single submitter ⚠
- p.Val254Met Single submitter ⚠
- p.Val354Ala Single submitter ⚠
- p.Val382Ile Single submitter ⚠
- p.Val588Ile Single submitter ⚠
- p.Val746Leu Single submitter ⚠