CDIPT — 21 ClinVar variants
All ClinVar germline CDIPT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
21 Uncertain significance
Full CDIPT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDIPT p.Ala206Val Uncertain significance Single submitter
- CDIPT p.Arg115Gln Uncertain significance Single submitter
- CDIPT p.Arg138Lys Uncertain significance Single submitter
- CDIPT p.Asp50Gly Uncertain significance Single submitter
- CDIPT p.His110Gln Uncertain significance Single submitter
- CDIPT p.Leu67Val Uncertain significance Single submitter
- CDIPT p.Met77Val Uncertain significance Single submitter
- CDIPT p.Ser187Leu Uncertain significance Single submitter
- CDIPT p.Thr71Met Uncertain significance Single submitter
- CDIPT p.Val114Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CDIPT p.Ala140Ser Uncertain significance Single submitter
- CDIPT p.Ala146Ser Uncertain significance Single submitter
- CDIPT p.Ala22Ser Uncertain significance Single submitter
- CDIPT p.Ala48Thr Uncertain significance Single submitter
- CDIPT p.Ala84Val Uncertain significance Single submitter
- CDIPT p.Arg173Trp Uncertain significance Single submitter
- CDIPT p.Arg199His Uncertain significance Single submitter
- CDIPT p.Arg62Gln Uncertain significance Single submitter
- CDIPT p.His52Gln Uncertain significance Single submitter
- CDIPT p.Ile192Thr Uncertain significance Single submitter
- CDIPT p.Tyr27Cys Uncertain significance Single submitter
All CDIPT variants
Uncertain significance 21
- p.Ala140Ser Single submitter ⚠
- p.Ala146Ser Single submitter ⚠
- p.Ala206Val Single submitter ⚠
- p.Ala22Ser Single submitter ⚠
- p.Ala48Thr Single submitter ⚠
- p.Ala84Val Single submitter ⚠
- p.Arg115Gln Single submitter ⚠
- p.Arg138Lys Single submitter ⚠
- p.Arg173Trp Single submitter ⚠
- p.Arg199His Single submitter ⚠
- p.Arg62Gln Single submitter ⚠
- p.Asp50Gly Single submitter ⚠
- p.His110Gln Single submitter ⚠
- p.His52Gln Single submitter ⚠
- p.Ile192Thr Single submitter ⚠
- p.Leu67Val Single submitter ⚠
- p.Met77Val Single submitter ⚠
- p.Ser187Leu Single submitter ⚠
- p.Thr71Met Single submitter ⚠
- p.Tyr27Cys Single submitter ⚠
- p.Val114Ile Single submitter ⚠