CDK7 — 24 ClinVar variants
All ClinVar germline CDK7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Likely benign · 23 Uncertain significance
Full CDK7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK7 p.Ala180Thr Uncertain significance Single submitter
- CDK7 p.Ala324Pro Uncertain significance Single submitter
- CDK7 p.Asp104Gly Uncertain significance Single submitter
- CDK7 p.Glu319Val Uncertain significance Single submitter
- CDK7 p.Leu145Val Uncertain significance Single submitter
- CDK7 p.Leu340Ser Uncertain significance Single submitter
- CDK7 p.Lys291Ile Uncertain significance Single submitter
- CDK7 p.Met196Thr Uncertain significance Single submitter
- CDK7 p.Phe162Ser Uncertain significance Single submitter
- CDK7 p.Pro299Ala Uncertain significance Single submitter
- CDK7 p.Tyr27Cys Uncertain significance Single submitter
- CDK7 p.Val199Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CDK7 p.Arg11Leu Uncertain significance Single submitter
- CDK7 p.Arg11Ser Uncertain significance Single submitter
- CDK7 p.Arg309Ser Uncertain significance Single submitter
- CDK7 p.Asn35Tyr Uncertain significance Single submitter
- CDK7 p.Asn86Asp Uncertain significance Single submitter
- CDK7 p.Asp146Glu Uncertain significance Single submitter
- CDK7 p.Asp267Asn Uncertain significance Single submitter
- CDK7 p.Met240Thr Uncertain significance Single submitter
- CDK7 p.Phe276Leu Uncertain significance Single submitter
- CDK7 p.Val199Ile Uncertain significance Single submitter
- CDK7 p.Val210Ile Uncertain significance Single submitter
All CDK7 variants
Likely benign 1
- p.Leu3Val Single submitter
Uncertain significance 23
- p.Ala180Thr Single submitter ⚠
- p.Ala324Pro Single submitter ⚠
- p.Arg11Leu Single submitter ⚠
- p.Arg11Ser Single submitter ⚠
- p.Arg309Ser Single submitter ⚠
- p.Asn35Tyr Single submitter ⚠
- p.Asn86Asp Single submitter ⚠
- p.Asp104Gly Single submitter ⚠
- p.Asp146Glu Single submitter ⚠
- p.Asp267Asn Single submitter ⚠
- p.Glu319Val Single submitter ⚠
- p.Leu145Val Single submitter ⚠
- p.Leu340Ser Single submitter ⚠
- p.Lys291Ile Single submitter ⚠
- p.Met196Thr Single submitter ⚠
- p.Met240Thr Single submitter ⚠
- p.Phe162Ser Single submitter ⚠
- p.Phe276Leu Single submitter ⚠
- p.Pro299Ala Single submitter ⚠
- p.Tyr27Cys Single submitter ⚠
- p.Val199Ile Single submitter ⚠
- p.Val199Leu Single submitter ⚠
- p.Val210Ile Single submitter ⚠